{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T20:30:38Z","timestamp":1694637038019},"reference-count":39,"publisher":"Hindawi Limited","issue":"3","license":[{"start":{"date-parts":[[2009,4,14]],"date-time":"2009-04-14T00:00:00Z","timestamp":1239667200000},"content-version":"unspecified","delay-in-days":9996,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genet. Res."],"published-print":{"date-parts":[[1981,12]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>This report examines several issues bearing upon intragenic recombination in higher eukaryotes. The fine structure data accumulated in our analysis of the genetic organization of the rosy locus in<jats:italic>Drosophila melanogaster<\/jats:italic>. Firstly, we confirm that a conversion event has a markedly less than 50% probability of resulting in flanking marker exchange, a finding consistent with more recent analyses of the available<jats:italic>Saccharomyces<\/jats:italic>data (e.g. Fogel<jats:italic>et al.<\/jats:italic>1978). As reported earlier, co-conversion of recombinationally separable sites within the<jats:italic>rosy<\/jats:italic>locus occurs (McCarron, Gelbart &amp; Chovnick, 1974). In this report, we demonstrate that the frequency of co-conversion is inversely proportional to the distance between co-converting sites. As in fungi, real conversion frequency differences are observed among<jats:italic>rosy<\/jats:italic>mutant alleles, and the data suggest that there may be a relationship between allele conversion frequency and map position. Unlike<jats:italic>Neurospora<\/jats:italic>and<jats:italic>Saccharomyces<\/jats:italic>, only one flanking marker exchange class is recovered from any given mutant heteroallele recombination experiment. In this respect, the<jats:italic>Drosophila<\/jats:italic>system resembles<jats:italic>Aspergillus<\/jats:italic>. As in<jats:italic>Neurospora<\/jats:italic>and<jats:italic>Saccharomyces, rosy<\/jats:italic>locus intragenic recombinants associated with flanking marker exchange exhibit interference with crossing over in adjacent regions, while no interference is seen among recombinants exhibiting parental flanking markers. Finally, experimental results are discussed which demonstrate the occurrence of postmeiotic segregation in<jats:italic>Drosophila<\/jats:italic>. These analogies between<jats:italic>Drosophila<\/jats:italic>and fungi provide further evidence in support of the notion that eukaryotes share common molecular mechanism(s) of meiotic recombination.<\/jats:p>","DOI":"10.1017\/s0016672300020619","type":"journal-article","created":{"date-parts":[[2009,9,17]],"date-time":"2009-09-17T07:42:59Z","timestamp":1253173379000},"page":"281-296","source":"Crossref","is-referenced-by-count":32,"title":["Further observations on intragenic recombination in<i>Drosophila melanogaster<\/i>"],"prefix":"10.1155","volume":"38","author":[{"given":"Arthur J.","family":"Hilliker","sequence":"first","affiliation":[]},{"given":"Arthur","family":"Chovnick","sequence":"additional","affiliation":[]}],"member":"98","published-online":{"date-parts":[[2009,4,14]]},"reference":[{"key":"S0016672300020619_ref012","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.1978.042.01.101"},{"key":"S0016672300020619_ref037","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.45.11.1625"},{"key":"S0016672300020619_ref015","first-page":"89","article-title":"Gene conversion in unselected tetrads from multipoint crosses","volume":"1","author":"Fogel","year":"1971","journal-title":"Stadler Genetics Symposia"},{"key":"S0016672300020619_ref026","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ge.02.120168.000413"},{"key":"S0016672300020619_ref027","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/genetics\/76.2.289","article-title":"Intracistronic mapping of electrophoretic sites in Drosophila melanogaster: Fidelity of information transfer by gene 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