{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T07:09:06Z","timestamp":1775459346873,"version":"3.50.1"},"reference-count":19,"publisher":"Hindawi Limited","issue":"2","license":[{"start":{"date-parts":[[2009,4,14]],"date-time":"2009-04-14T00:00:00Z","timestamp":1239667200000},"content-version":"unspecified","delay-in-days":9327,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genet. Res."],"published-print":{"date-parts":[[1983,10]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The steel allele, contrasted (<jats:italic>Sl<\/jats:italic><jats:sup><jats:italic>con<\/jats:italic><\/jats:sup>), arose in a neutron irradiation experiment.<jats:italic>Sl<\/jats:italic><jats:sup><jats:italic>con<\/jats:italic><\/jats:sup>is fully penetrant and heterozygotes can be recognized at or soon after birth by darkly pigmented external genitalia in both sexes, while the adult coat tends to be a little lighter than normal. Homozygotes also have dark genitalia and a markedly diluted coat. Both eumelanin and phaeomelanin are affected, with reduced numbers of cortical and medullary pigment granules in the hairs. Contrasted also affects the haematopoietic system, causing slight macrocytic anaemia in the homozygote.<jats:italic>Sl<\/jats:italic><jats:sup><jats:italic>con<\/jats:italic><\/jats:sup>homozygous males are fertile but testes weigh on average 20% less than in their heterozygous litter-mates. Homozygous females are usually sterile although if mated early (4\u00bd\u22126 weeks) they occasionally have a single litter. Ovarian sections showed a gradual degeneration of oocytes in Graafian follicles so that most had gone by 2 months. Similarly, vaginal smears indicated that after about three normal cycles homozygous females lapsed into a state of persistent dioestrus; injections with gonadotrophins did not prolong their period of fertility or cause a resumption of their oestrous cycles. The effects on fertility, pigmentation and haematology of contrasted when combined with other steel alleles are also described.<\/jats:p>","DOI":"10.1017\/s0016672300021649","type":"journal-article","created":{"date-parts":[[2009,9,17]],"date-time":"2009-09-17T07:41:12Z","timestamp":1253173272000},"page":"183-191","source":"Crossref","is-referenced-by-count":11,"title":["Contrasted, a steel allele in the mouse with intermediate effects"],"prefix":"10.1155","volume":"42","author":[{"given":"C. V.","family":"Beechey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. G.","family":"Searle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","published-online":{"date-parts":[[2009,4,14]]},"reference":[{"key":"S0016672300021649_ref018","first-page":"361","article-title":"Melanocytes and melanin in human abdominal wall skin: a survey made at different ages in both sexes and during pregnancy","volume":"97","author":"Snell","year":"1963","journal-title":"Journal of Anatomy"},{"key":"S0016672300021649_ref005","volume-title":"Genetic Variants and Strains of the Laboratory Mouse","author":"Green","year":"1981"},{"key":"S0016672300021649_ref016","doi-asserted-by":"publisher","DOI":"10.1159\/000130859"},{"key":"S0016672300021649_ref010","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1182\/blood.V26.4.399.399","article-title":"The cellular basis of the genetically determined hemopoietic defect in anemic mice of genotype Sl\/Sld","volume":"26","author":"McCulloch","year":"1965","journal-title":"Blood"},{"key":"S0016672300021649_ref017","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-6164-3"},{"key":"S0016672300021649_ref002","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1050980202"},{"key":"S0016672300021649_ref009","doi-asserted-by":"publisher","DOI":"10.1007\/BF01932475"},{"key":"S0016672300021649_ref014","first-page":"397","article-title":"Hereditary anaemias of the mouse: a review for geneticists","volume":"20","author":"Russell","year":"1979","journal-title":"Advances in Genetics"},{"key":"S0016672300021649_ref011","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-611909-1.50006-0"},{"key":"S0016672300021649_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(66)90063-7"},{"key":"S0016672300021649_ref019","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-185X.1975.tb00989.x"},{"key":"S0016672300021649_ref015","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(74)90009-8"},{"key":"S0016672300021649_ref003","doi-asserted-by":"publisher","DOI":"10.1017\/S0016672300009587"},{"key":"S0016672300021649_ref013","first-page":"279","volume-title":"Genetic Variants and Strains of the Laboratory Mouse","author":"Roderick","year":"1981"},{"key":"S0016672300021649_ref006","first-page":"145","article-title":"Threshold phenomena versus cell heredity in the manifestation of sex linked genes in mammals","volume":"22","author":"Gr\u00fcneberg","year":"1969","journal-title":"Journal of Embryology and Experimental Morphology"},{"key":"S0016672300021649_ref012","first-page":"1167","volume-title":"The Physiology and Pathophysiology of the Skin","volume":"3","author":"Riley","year":"1974"},{"key":"S0016672300021649_ref007","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401840308"},{"key":"S0016672300021649_ref004","first-page":"91","article-title":"The effect of melanocyte-stimulating hormone on coat colour in the mouse","volume":"28","author":"Geschwind","year":"1972","journal-title":"Recent Progress in Hormone Research"},{"key":"S0016672300021649_ref008","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(68)90023-7"}],"container-title":["Genetical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0016672300021649","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T22:47:00Z","timestamp":1609454820000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0016672300021649\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,10]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1983,10]]}},"alternative-id":["S0016672300021649"],"URL":"https:\/\/doi.org\/10.1017\/s0016672300021649","relation":{},"ISSN":["0016-6723","1469-5073"],"issn-type":[{"value":"0016-6723","type":"print"},{"value":"1469-5073","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,10]]}}}