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I often reread her original papers setting forth the single active X hypothesis, and still marvel at the concise and compelling exposition of the hypothesis and the logical predictions which seemed prophetic at my first reading, and have survived the test of time.<\/jats:p><jats:p>My contribution to this Festschrift reviews evidence derived from studies of DNA methylation, species variation and DNA replication that reveals an important role for methylated CpG islands and suggests a role for late DNA replication in propagating X inactivation from one cell to its progeny. These studies also show that X inactivation is a powerful research tool for identifying the factors which program and maintain developmental processes.<\/jats:p>","DOI":"10.1017\/s0016672300035151","type":"journal-article","created":{"date-parts":[[2009,9,17]],"date-time":"2009-09-17T07:30:40Z","timestamp":1253172640000},"page":"91-98","source":"Crossref","is-referenced-by-count":31,"title":["Insights into X chromosome inactivation from studies of species variation, DNA methylation and replication, and vice versa"],"prefix":"10.1155","volume":"56","author":[{"given":"Barbara R.","family":"Migeon","sequence":"first","affiliation":[]}],"member":"98","published-online":{"date-parts":[[2009,4,14]]},"reference":[{"key":"S0016672300035151_ref064","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/j.1460-2075.1988.tb02827.x","article-title":"Expression of the G6PD locus on the human X chromosome is associated with demethylation of three CpG clusters within 100 kb of DNA","volume":"7","author":"Toniolo","year":"1988","journal-title":"EMBO Journal"},{"key":"S0016672300035151_ref001","doi-asserted-by":"publisher","DOI":"10.1038\/311374a0"},{"key":"S0016672300035151_ref005","doi-asserted-by":"publisher","DOI":"10.1038\/315496a0"},{"key":"S0016672300035151_ref043","doi-asserted-by":"publisher","DOI":"10.1038\/299838a0"},{"key":"S0016672300035151_ref027","doi-asserted-by":"publisher","DOI":"10.1071\/BI9780415"},{"key":"S0016672300035151_ref002","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.9.6.2322"},{"key":"S0016672300035151_ref046","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.14.4954"},{"key":"S0016672300035151_ref009","first-page":"A111","article-title":"Evidence for lack of DNA methylation in human fetal germ cells: Relevance to parental chromosome imprinting and CpG mutation","volume":"45","author":"Driscoll","year":"1989","journal-title":"The American Journal of Human Genetics"},{"key":"S0016672300035151_ref008","doi-asserted-by":"publisher","DOI":"10.1007\/BF00278187"},{"key":"S0016672300035151_ref039","doi-asserted-by":"publisher","DOI":"10.1038\/326501a0"},{"key":"S0016672300035151_ref033","doi-asserted-by":"publisher","DOI":"10.1007\/BF01538681"},{"key":"S0016672300035151_ref011","first-page":"124","article-title":"Maternal X chromosome expression in mouse chorionic ectoderm","volume":"1","author":"Frels","year":"1980","journal-title":"Developmental Genetics"},{"key":"S0016672300035151_ref032","doi-asserted-by":"publisher","DOI":"10.1038\/319224a0"},{"key":"S0016672300035151_ref012","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(75)90127-5"},{"key":"S0016672300035151_ref065","doi-asserted-by":"publisher","DOI":"10.1007\/BF01574262"},{"key":"S0016672300035151_ref051","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.7.11.3916"},{"key":"S0016672300035151_ref028","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.72.4.1510"},{"key":"S0016672300035151_ref026","doi-asserted-by":"publisher","DOI":"10.1007\/BF00333993"},{"key":"S0016672300035151_ref023","doi-asserted-by":"publisher","DOI":"10.1126\/science.1111098"},{"key":"S0016672300035151_ref010","doi-asserted-by":"publisher","DOI":"10.1007\/BF01233363"},{"key":"S0016672300035151_ref063","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(83)90563-9"},{"key":"S0016672300035151_ref015","doi-asserted-by":"publisher","DOI":"10.1126\/science.6719109"},{"key":"S0016672300035151_ref013","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ge.17.120183.001103"},{"key":"S0016672300035151_ref040","doi-asserted-by":"publisher","DOI":"10.1038\/335093a0"},{"key":"S0016672300035151_ref056","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/genetics\/115.1.185","article-title":"X-linked gene expression in the Virginia opossum: differences between the paternally derived Gpd and Pgk-A loci","volume":"115","author":"Samollow","year":"1987","journal-title":"Genetics"},{"key":"S0016672300035151_ref062","doi-asserted-by":"publisher","DOI":"10.1038\/256640a0"},{"key":"S0016672300035151_ref006","unstructured":"Chapman V. 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