{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T06:56:47Z","timestamp":1760079407637},"reference-count":33,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T00:00:00Z","timestamp":1242345600000},"content-version":"unspecified","delay-in-days":19615,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["J. Hyg."],"published-print":{"date-parts":[[1955,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>1. The serum proteins of calves from birth to weaning, and the maternal colostral whey have been examined with the \u2018classical\u2019 Tiselius electrophoresis apparatus. Differences were shown between calves fed colostrum and those partially deprived of colostrum.<\/jats:p><jats:p>2. A study of the pre-colostral calf serum showed the presence of albumin and of two major components with mobilities similar to the \u03b1 and \u03b2 globulins of adult serum. A component forming approximately 1\u00b74 % of the total serum proteins and with a mobility similar to that of \u03b3<jats:sub>1<\/jats:sub>or fibrinogen represented the \u03b3<jats:sub>1<\/jats:sub>globulin. This globulin component was not unconverted fibrinogen and may be autogenous \u03b3 globulin or \u03b3 globulin passively acquired<jats:italic>in utero<\/jats:italic>.<\/jats:p><jats:p>3. Autogenous \u03b3 globulin was evident in colostrum-fed and colostrum-deprived calves shortly after birth. The \u03b3<jats:sub>1<\/jats:sub>and \u03b3<jats:sub>2<\/jats:sub>components could be distinguished by the 10th day after birth, at which time the \u03b3<jats:sub>1<\/jats:sub>globulin was the greater. By the 30th day the \u03b3<jats:sub>2<\/jats:sub>globulin exceeded the \u03b3<jats:sub>1<\/jats:sub>globulin and a smaller component termed the \u03b3<jats:sub>3<\/jats:sub>globulin could usually be detected between the \u03b3<jats:sub>2<\/jats:sub>and the salt boundary.<\/jats:p><jats:p>4. Albumin concentrations generally fluctuated inversely to changes in the total serum globulins.<\/jats:p><jats:p>5. The \u03b1 globulins associated with fetuin declined shortly after birth in the colostrum-fed group. In the deprived group \u03b1 globulin first rose and then fell. In both groups minimum \u03b1 globulin values were reached at about the 30th day, when the \u03b1<jats:sub>1<\/jats:sub>globulin, although initially the major component in pre-colostral calf serum, was more depleted than the \u03b1<jats:sub>2<\/jats:sub>.<\/jats:p><jats:p>6. The \u03b2 globulin frequently showed a transient though marked increase when the \u03b1 globulins were at their lowest values.<\/jats:p><jats:p>7. No changes in the electrophoretic mobilities of the major serum proteins were detected as the calves matured, and no significant difference was found between the mobilities of the electrophoretic components of calf and adult sera.<\/jats:p><jats:p>8. The electrophoretic examination of colostral whey, colostral lacto-globulin fractions and calf serum immediately after suckling usually showed one lacto-globulin component. The relationship between the serum \u03b3 globulins and the lacto-globulin. is discussed.<\/jats:p><jats:p>The author wishes to thank Dr M. Robertson, F.R.S., and Sir Alan Drury, F.R.S. for their interest and encouragement during the course of this work, Dr W. R. Kerr for his co-operation in supplying most of the serum and colostrum samples, and Dr A. W. Stableforth and Dr J. S. Paterson for making certain cattle available for these experiments.<\/jats:p>","DOI":"10.1017\/s0022172400000747","type":"journal-article","created":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T10:33:35Z","timestamp":1242383615000},"page":"247-260","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":34,"title":["Electrophoretic and Immunological Studies on Sera from Calves from Birth to Weaning I. Electrophoretic Studies"],"prefix":"10.1017","volume":"53","author":[{"given":"A. 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