{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T00:33:41Z","timestamp":1715992421036},"reference-count":16,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T00:00:00Z","timestamp":1242345600000},"content-version":"unspecified","delay-in-days":20802,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["J. Hyg."],"published-print":{"date-parts":[[1952,6]]},"abstract":"<jats:p>Influenza virus elementary bodies can be disintegrated by treatment with ether with the liberation of two types of smaller particle, soluble antigen and red cell agglutinin.<\/jats:p><jats:p>Soluble antigen derived from the elementary body is identical in serological and chemical behaviour with soluble antigen recovered from infected tissues. Its chemical properties are those of a ribonucleoprotein.<\/jats:p><jats:p>The agglutinin is an enzyme, with a protein part carrying the enzymic activity and a combining group with affinity for red cells. The agglutinin does not react in complement-fixation tests by the short fixation technique, but by the use of prolonged fixation or by indirect complement fixation it can be shown to contain a strain specific antigen and also a non-specific antigen. The specific antigen is identical with the specific complement-fixing antigen demonstrable in the intact elementary body, and has combining affinity for red blood cells. The non-specific antigen is probably similar to the protein part of the soluble antigen. No evidence has been found that the agglutinin contains either carbohydrate or nucleic acid.<\/jats:p><jats:p>From the ether used to disintegrate the elementary body a serologically active lipid can be recovered which has properties suggesting that it is derived from the host cell.<\/jats:p><jats:p>The author is greatly indebted to Dr L. Dmochowski for assistance in experiments involving high-speed centrifugation, to Sir Macfarlane Burnet and Dr G. L. Ada for supplies of receptor-destroying enzyme, to Dr E. S. Duthie for crystalline trypsin and chymotrypsin, and to Dr R. R. Porter for a sample of crystalline ribonuclease.<\/jats:p>","DOI":"10.1017\/s0022172400019562","type":"journal-article","created":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T09:25:16Z","timestamp":1242379516000},"page":"229-245","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":133,"title":["Structure of the influenza virus. The relation between biological activity and chemical structure of virus fractions"],"prefix":"10.1017","volume":"50","author":[{"given":"L.","family":"Hoyle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,5,15]]},"reference":[{"key":"S0022172400019562_ref016","doi-asserted-by":"publisher","DOI":"10.1038\/icb.1949.36"},{"key":"S0022172400019562_ref015","first-page":"232","volume-title":"Crystalline Enzymes","author":"Northrop","year":"1948"},{"key":"S0022172400019562_ref014","doi-asserted-by":"publisher","DOI":"10.1084\/jem.85.1.99"},{"key":"S0022172400019562_ref007","doi-asserted-by":"publisher","DOI":"10.1084\/jem.89.2.233"},{"key":"S0022172400019562_ref005","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-57-14744"},{"key":"S0022172400019562_ref004","doi-asserted-by":"publisher","DOI":"10.1139\/cjr50e-026"},{"key":"S0022172400019562_ref002","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-5-1-67"},{"key":"S0022172400019562_ref001","first-page":"83","volume":"10","author":"Anderson","year":"1947","journal-title":"Aust. J. Sci."},{"key":"S0022172400019562_ref011","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400035233"},{"key":"S0022172400019562_ref006","doi-asserted-by":"publisher","DOI":"10.1084\/jem.87.4.315"},{"key":"S0022172400019562_ref003","doi-asserted-by":"publisher","DOI":"10.1038\/icb.1949.8"},{"key":"S0022172400019562_ref013","doi-asserted-by":"publisher","DOI":"10.1084\/jem.83.4.281"},{"key":"S0022172400019562_ref008","doi-asserted-by":"publisher","DOI":"10.1017\/S002217240001336X"},{"key":"S0022172400019562_ref010","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400015072"},{"key":"S0022172400019562_ref012","unstructured":"Hoyle L. , Reed R. & Astbury W. T. (1952). (In the Press.)"},{"key":"S0022172400019562_ref009","first-page":"390","volume":"29","author":"Hoyle","year":"1948","journal-title":"Brit. J. exp. Path."}],"container-title":["Journal of Hygiene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022172400019562","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T06:42:00Z","timestamp":1559889720000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022172400019562\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1952,6]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1952,6]]}},"alternative-id":["S0022172400019562"],"URL":"https:\/\/doi.org\/10.1017\/s0022172400019562","relation":{},"ISSN":["0022-1724"],"issn-type":[{"value":"0022-1724","type":"print"}],"subject":[],"published":{"date-parts":[[1952,6]]},"assertion":[{"value":"Copyright \u00a9 Cambridge University Press 1952","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}