{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:39:17Z","timestamp":1760204357974},"reference-count":19,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T00:00:00Z","timestamp":1242345600000},"content-version":"unspecified","delay-in-days":13132,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["J. Hyg."],"published-print":{"date-parts":[[1973,6]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>After one passage of influenza A2\/Singapore\/l\/57 virus in mice treated with 150 mg.\/kg.\/day of aminoadamantane, a partially drug-resistant strain of virus was detected in 1 of 12 mice. The isolation rate of aminoadamantane-resistant viruses increased to 8 after three passages in drug-treated mice. Some virus strains showed a 500-fold increase in resistance to aminoadamantane and to the structurally related compounds \u03b1-methyl-1-adamantane methylamine and 2-adamantanamine sulphate. No aminoadamantane-resistant viruses were detected after passage of influenza four times in mice treated with lower (15 or 1\u00b75 mg.\/kg.\/day) concentrations of aminoadamantane. Aminoadamantane had no detectable effect on the development of lung lesions in mice infected with the drug-resistant influenza strain, whereas lung lesions were reduced in aminoadamantane treated mice infected with a control strain of influenza A2\/Singapore virus. No differences were detected in the buoyant density in caesium chloride, morphology or serology between control and aminoadamantane-resistant strains of virus. These drug-resistant influenza viruses may be useful for detailed studies of the mode of action of aminoadamantane.<\/jats:p>","DOI":"10.1017\/s0022172400022701","type":"journal-article","created":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T10:07:56Z","timestamp":1242382076000},"page":"227-236","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":16,"title":["Aminoadamantane-resistant strains of influenza A2 virus"],"prefix":"10.1017","volume":"71","author":[{"given":"J. S.","family":"Oxford","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. W.","family":"Potter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,5,15]]},"reference":[{"key":"S0022172400022701_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(63)90141-7"},{"key":"S0022172400022701_ref016","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1128\/AEM.21.4.606-610.1971","article-title":"Inactivation of influenza and other viruses by a mixture of virucidal compounds","volume":"21","author":"Oxford","year":"1971","journal-title":"Applied Microbiology"},{"key":"S0022172400022701_ref006","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1128\/JB.90.3.623-628.1965","article-title":"Mode of action of the antiviral activity of amantadine in tissue culture","volume":"90","author":"Hoffmann","year":"1965","journal-title":"Journal of Bacteriology"},{"key":"S0022172400022701_ref018","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400041759"},{"key":"S0022172400022701_ref001","doi-asserted-by":"publisher","DOI":"10.1084\/jem.113.4.657"},{"key":"S0022172400022701_ref013","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-5-4-565"},{"key":"S0022172400022701_ref019","doi-asserted-by":"publisher","DOI":"10.1038\/222341a0"},{"key":"S0022172400022701_ref012","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-2-3-377"},{"key":"S0022172400022701_ref010","doi-asserted-by":"publisher","DOI":"10.1007\/BF01250291"},{"key":"S0022172400022701_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(71)92299-9"},{"key":"S0022172400022701_ref008","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(69)90281-5"},{"key":"S0022172400022701_ref004","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1970.tb53388.x"},{"key":"S0022172400022701_ref009","volume-title":"In Fundamental Techniques in Virology","author":"Laver","year":"1969"},{"key":"S0022172400022701_ref014","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1970.tb53420.x"},{"key":"S0022172400022701_ref015","doi-asserted-by":"publisher","DOI":"10.1038\/226082a0"},{"key":"S0022172400022701_ref017","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1965.tb12568.x"},{"key":"S0022172400022701_ref003","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(64)90212-0"},{"key":"S0022172400022701_ref011","doi-asserted-by":"publisher","DOI":"10.1126\/science.134.3478.557"},{"key":"S0022172400022701_ref007","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1749-6632.1970.tb53386.x","article-title":"Evaluation of amantadine hydrochloride in the treatment of A2 influenza disease","volume":"173","author":"Iezzoni","year":"1970","journal-title":"Annals of the New York Academy of Sciences"}],"container-title":["Journal of Hygiene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022172400022701","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T05:13:55Z","timestamp":1589778835000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022172400022701\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,6]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1973,6]]}},"alternative-id":["S0022172400022701"],"URL":"https:\/\/doi.org\/10.1017\/s0022172400022701","relation":{},"ISSN":["0022-1724"],"issn-type":[{"value":"0022-1724","type":"print"}],"subject":[],"published":{"date-parts":[[1973,6]]},"assertion":[{"value":"Cambridge University Press 1973","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}