{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:26:55Z","timestamp":1762176415979},"reference-count":16,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2010,3,25]],"date-time":"2010-03-25T00:00:00Z","timestamp":1269475200000},"content-version":"unspecified","delay-in-days":9976,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["J. Hyg."],"published-print":{"date-parts":[[1982,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Enterotoxin production by strains<jats:italic>of Staphylococcus aureus<\/jats:italic>isolated from clinical specimens of human and animal origin and from healthy human carriers was investigated. All nine patients admitted to hospital with symptoms of toxic shock syndrome (TSS) yielded enterotoxin-producing strains of<jats:italic>S. aureus<\/jats:italic>. Eight of these produced staphylococcal enterotoxin F (SEF). A significantly smaller proportion of strains (42% of 50 strains tested) isolated from other clinical specimens of hospitalized patients produced SEF. Production of SEF by strains isolated from clinical specimens of animal origin (48 strains) was not observed. Twenty-nine per cent of 24<jats:italic>S. aureus<\/jats:italic>strains isolated from noses of hospital staff produced SEF. This result was not significantly different from that obtained from strains isolated from clinical specimens other than TSS. A similar percentage of strains isolated from healthy human carriers outside hospital produced SEF (25% of 24 strains tested).<\/jats:p><jats:p>The results indicated that enterotoxin production, especially that of SEF. is associated with<jats:italic>S. aureus<\/jats:italic>isolated from patients suspected of TSS. There was no indication of an association between<jats:italic>S. aureus<\/jats:italic>isolated from other staphylococcal infections and SEF production.<\/jats:p><jats:p>All strains were phage typed and 79%, of the strains belonging to the international phage-group I produced SEF. All strains lysed by phage 187 were found to produce SEF.<\/jats:p>","DOI":"10.1017\/s0022172400071060","type":"journal-article","created":{"date-parts":[[2010,3,25]],"date-time":"2010-03-25T13:12:21Z","timestamp":1269522741000},"page":"499-505","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":17,"title":["Enterotoxin production by strains of<i>Staphylococcus aureus<\/i>isolated from clinical and non-clinical specimens with special reference to enterotoxin F and toxic shock syndrome"],"prefix":"10.1017","volume":"89","author":[{"given":"Marianne P.","family":"De Nooij","sequence":"first","affiliation":[]},{"given":"Wijnanda J.","family":"van Leeuwen","sequence":"additional","affiliation":[]},{"given":"Serve","family":"Notermans","sequence":"additional","affiliation":[]}],"member":"56","published-online":{"date-parts":[[2010,3,25]]},"reference":[{"key":"S0022172400071060_ref005","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1128\/JB.94.6.1875-1882.1967","article-title":"Identification of a fourth Staphylococcal enterotoxin, enterotoxin D","volume":"94","author":"Casman","year":"1967","journal-title":"Journal of Bacteriology"},{"key":"S0022172400071060_ref014","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)92274-2"},{"key":"S0022172400071060_ref013","doi-asserted-by":"publisher","DOI":"10.4315\/0362-028X-43.9.683"},{"key":"S0022172400071060_ref010","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-25-2-241"},{"key":"S0022172400071060_ref003","doi-asserted-by":"publisher","DOI":"10.1093\/labmed\/12.10.621"},{"key":"S0022172400071060_ref015","first-page":"1013","article-title":"An additional set of phages for the typing of Staphylococcus aureus strains of human origin and non-typable with the international basic set of phages","volume":"5","author":"van Leeuwen","year":"1976","journal-title":"Zentralblatt f\u00fcr Bakteriologie Mikrobiologie und Hygiene, I. Abteilung. Supplement Heft"},{"key":"S0022172400071060_ref016","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400024104"},{"key":"S0022172400071060_ref012","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/143.4.509"},{"key":"S0022172400071060_ref011","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1128\/AEM.28.6.946-950.1974","article-title":"Detecting the enterotoxigenity of Staphylococcus aureus strains","volume":"28","author":"Robbins","year":"1974","journal-title":"Applied Microbiology"},{"key":"S0022172400071060_ref008","doi-asserted-by":"crossref","unstructured":"Notermans S. & Dufrenne J. (1982). A simple purification method for enterotoxin F produced by Staphylococcus aureus and some properties of the toxin. Antonie van Leeuwenhoek. (In the Press.)","DOI":"10.1007\/BF00448416"},{"key":"S0022172400071060_ref006","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198012183032501"},{"key":"S0022172400071060_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)92186-3"},{"key":"S0022172400071060_ref001","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.1971.tb02277.x"},{"key":"S0022172400071060_ref009","first-page":"1","article-title":"Diffusion-in-gel in methods from immunological analysis","volume":"5","author":"Ouchterlony","year":"1958","journal-title":"Progress in Allergy"},{"key":"S0022172400071060_ref004","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0450.1981.tb01766.x"},{"key":"S0022172400071060_ref007","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1128\/AEM.15.6.1382-1387.1967","article-title":"Serological identification of enterotoxigenic staphylococci from cheese","volume":"15","author":"Donelly","year":"1967","journal-title":"Applied Microbiology"}],"container-title":["Journal of Hygiene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022172400071060","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T08:38:36Z","timestamp":1591173516000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022172400071060\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,12]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1982,12]]}},"alternative-id":["S0022172400071060"],"URL":"https:\/\/doi.org\/10.1017\/s0022172400071060","relation":{},"ISSN":["0022-1724"],"issn-type":[{"value":"0022-1724","type":"print"}],"subject":[],"published":{"date-parts":[[1982,12]]},"assertion":[{"value":"Cambridge University Press 1982","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}