{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T14:27:41Z","timestamp":1773757661176,"version":"3.50.1"},"reference-count":38,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":6945,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1990,4]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Baseline data from an immuno-epidemiological study of hookworm infection in a rural village in Madang Province, Papua New Guinea are reported. <jats:italic>Necator americanus<\/jats:italic> was found to be the commonest helminth infection, with a prevalence of near 100% and intensity of 40 worms per host in adults. <jats:italic>Enterobius vermicularis, Ascaris lumbricoides<\/jats:italic> and <jats:italic>Trichuris trichiura<\/jats:italic> were also present, at prevalences of 53, 10 and 3% respectively; <jats:italic>Ancylostoma duodenale<\/jats:italic> was absent. The frequency distribution of <jats:italic>N. americanus<\/jats:italic> was highly over-dispersed, and was well described by a negative binomial distribution with aggregation parameter, k, of 0\u00b7370. Intensity of infection was significantly related to host age, but did not differ between the sexes. Haemoglobin levels and haematocrit values were indicative of anaemia in the community, but were unrelated to hookworm infection. Levels of antibodies (IgG, IgA and 1gM combined) against adult <jats:italic>Necator<\/jats:italic> cuticular collagen and excretory-secretory (ES) products were determined.<\/jats:p>","DOI":"10.1017\/s0031182000061333","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T10:42:16Z","timestamp":1244198536000},"page":"317-326","source":"Crossref","is-referenced-by-count":91,"title":["Epidemiology and immunology of <i>Necator americanus<\/i> infection in a community in Papua New Guinea: humoral responses to excretory-secretory and cuticular collagen antigens"],"prefix":"10.1017","volume":"100","author":[{"given":"D. I.","family":"Pritchard","sequence":"first","affiliation":[]},{"given":"R. J.","family":"Quinnell","sequence":"additional","affiliation":[]},{"given":"A. F. G.","family":"Slater","sequence":"additional","affiliation":[]},{"given":"P. G.","family":"McKean","sequence":"additional","affiliation":[]},{"given":"D. D. S.","family":"Dale","sequence":"additional","affiliation":[]},{"given":"A.","family":"Raiko","sequence":"additional","affiliation":[]},{"given":"A. E.","family":"Keymer","sequence":"additional","affiliation":[]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000061333_ref037","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/154.5.778"},{"key":"S0031182000061333_ref036","volume-title":"Nutrition in Preventive Medicine","author":"Waterlow","year":"1976"},{"key":"S0031182000061333_ref034","first-page":"621","volume-title":"The Epidemiological Sample Survey of the Highlands, Mainland and Island Regions of Papua New Guinea","author":"Vines","year":"1970"},{"key":"S0031182000061333_ref033","doi-asserted-by":"publisher","DOI":"10.1038\/icb.1980.25"},{"key":"S0031182000061333_ref032","first-page":"89","article-title":"Antigen-induced lymphocyte blastogenesis in a hookworm (Necator americanus) infection in man","volume":"27","author":"Taylor","year":"1976","journal-title":"Tropenmedizin und Parasitologie"},{"key":"S0031182000061333_ref031","first-page":"41","article-title":"Reinfection with intestinal helminths after treatment with mebendazole","volume":"27","author":"Shield","year":"1984","journal-title":"Papua New Guinea Medical Journal"},{"key":"S0031182000061333_ref029","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1966.15.1032"},{"key":"S0031182000061333_ref028","article-title":"The molecular basis of antigenic cross-reactivity between Necator americanus and Ascaris lumbricoides","author":"Pritchard","year":"1990","journal-title":"Parasite Immunology (in the Press)"},{"key":"S0031182000061333_ref024","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(78)90303-6"},{"key":"S0031182000061333_ref023","first-page":"492","article-title":"Mit Ascaris, Hakenwurm und Onchocerca \u2014 Antigenen kreuzreaginerende Seren aus Liberia, Westafrika","volume":"25","author":"Neppert","year":"1974","journal-title":"Tropenmedizin und Parasitologie"},{"key":"S0031182000061333_ref021","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1987.37.126"},{"key":"S0031182000061333_ref020","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(89)90478-1"},{"key":"S0031182000061333_ref019","volume-title":"Alimentary Parasites of Man in Papua New Guinea","author":"Kelly","year":"1974"},{"key":"S0031182000061333_ref018","first-page":"165","article-title":"A study of human helminthiasis on Karkar Island, Madang Province","volume":"19","author":"Jones","year":"1976","journal-title":"Papua New Guinea Medical Journal"},{"key":"S0031182000061333_ref015","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000080197"},{"key":"S0031182000061333_ref011","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1987.tb00502.x"},{"key":"S0031182000061333_ref008","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(87)90060-3"},{"key":"S0031182000061333_ref007","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5742.210"},{"key":"S0031182000061333_ref006","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(69)90011-X"},{"key":"S0031182000061333_ref004","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000052288"},{"key":"S0031182000061333_ref027","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(88)90012-6"},{"key":"S0031182000061333_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(86)90367-6"},{"key":"S0031182000061333_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(85)90128-2"},{"key":"S0031182000061333_ref009","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(08)60287-0"},{"key":"S0031182000061333_ref030","doi-asserted-by":"publisher","DOI":"10.1126\/science.4012307"},{"key":"S0031182000061333_ref022","unstructured":"Mckean P. G. (1989). Analysis of the antigens of the human hookworm Necator americanus. Unpublished Ph.D. thesis, University of Nottingham."},{"key":"S0031182000061333_ref014","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(81)90148-6"},{"key":"S0031182000061333_ref003","doi-asserted-by":"publisher","DOI":"10.1038\/315493a0"},{"key":"S0031182000061333_ref025","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1986.tb00852.x"},{"key":"S0031182000061333_ref017","first-page":"53","volume-title":"The Assessment of the Nutritional Status of the Community","author":"Jelliffe","year":"1966"},{"key":"S0031182000061333_ref035","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)92483-X"},{"key":"S0031182000061333_ref026","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(88)90137-8"},{"key":"S0031182000061333_ref016","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1975.24.590"},{"key":"S0031182000061333_ref001","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-93161-1_16"},{"key":"S0031182000061333_ref038","volume-title":"Control of nutritional anaemia with special reference to iron deficiency","year":"1975"},{"key":"S0031182000061333_ref012","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1974.tb01388.x"},{"key":"S0031182000061333_ref010","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(86)90007-1"},{"key":"S0031182000061333_ref013","first-page":"295","volume-title":"The Biology of Schistosomes","author":"Hagan","year":"1987"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000061333","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T17:33:14Z","timestamp":1558200794000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000061333\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,4]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1990,4]]}},"alternative-id":["S0031182000061333"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000061333","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,4]]}}}