{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:37:54Z","timestamp":1778621874094,"version":"3.51.4"},"reference-count":31,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,7,9]],"date-time":"2009-07-09T00:00:00Z","timestamp":1247097600000},"content-version":"unspecified","delay-in-days":9474,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[1983,8]]},"abstract":"<jats:title>Synopsis<\/jats:title><jats:p>Major affective disorder clinically similar to the disorder found in conditions other than Huntington's Disease (HD) was found in 41% of patients with HD in a consecutive case series ascertained through multiple sources in a defined geographical area. The association appears to be confined to certain families, and affective disorder may appear as long as 20 years before the onset of chorea and dementia. The association may represent genetic heterogeneity in HD.<\/jats:p>","DOI":"10.1017\/s0033291700047966","type":"journal-article","created":{"date-parts":[[2009,7,9]],"date-time":"2009-07-09T15:11:01Z","timestamp":1247152261000},"page":"537-542","source":"Crossref","is-referenced-by-count":159,"title":["The association of affective disorder with Huntington's Disease in a case series and in families"],"prefix":"10.1017","volume":"13","author":[{"given":"Susan E.","family":"Folstein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret H.","family":"Abbott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary A.","family":"Chase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara A.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marshal F.","family":"Folstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,7,9]]},"reference":[{"key":"S0033291700047966_ref013","volume-title":"The Detection of Psychiatric Illness by Questionnaire","author":"Goldberg","year":"1972"},{"key":"S0033291700047966_ref017","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/90.1.203"},{"key":"S0033291700047966_ref031","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1978.01770350030002"},{"key":"S0033291700047966_ref027","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1975.tb00340.x"},{"key":"S0033291700047966_ref020","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1974.01760160005001"},{"key":"S0033291700047966_ref018","first-page":"537","article-title":"Social significance of Huntington's Chorea","volume":"4","author":"Hughes","year":"1924","journal-title":"American Journal of Psychiatry"},{"key":"S0033291700047966_ref016","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320110203"},{"key":"S0033291700047966_ref014","first-page":"403","article-title":"A report of 27 cases of chronic progressive chorea","volume":"64","author":"Hamilton","year":"1908","journal-title":"American Journal of Insanity"},{"key":"S0033291700047966_ref007","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1981.tb00320.x"},{"key":"S0033291700047966_ref003","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.101.424.548"},{"key":"S0033291700047966_ref001","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.99.415.291"},{"key":"S0033291700047966_ref004","first-page":"298","volume-title":"Handbook of Clinical Neurology","volume":"6","author":"Bruyn","year":"1968"},{"key":"S0033291700047966_ref024","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.116.532.241"},{"key":"S0033291700047966_ref022","first-page":"267","volume-title":"Psychiatric Aspects of Neurologic Disease","author":"McHugh","year":"1975"},{"key":"S0033291700047966_ref009","unstructured":"Folstein M. F. , Folstein S. E. & Chase G. (1981). Clinical heterogeneity in Huntington's Disease.Paper presented at the First Boston Symposium on Huntington Disease,Boston. November."},{"key":"S0033291700047966_ref028","doi-asserted-by":"crossref","unstructured":"Thompson W. D. , Orvaschel H. , Prusoff B. A. & Kidd K. K. (1983). An evaluation of the family history method for ascertaining psychiatric cases Archives of General Psychiatry (In the press).","DOI":"10.1001\/archpsyc.1982.04290010031006"},{"key":"S0033291700047966_ref030","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.35.6.789"},{"key":"S0033291700047966_ref008","doi-asserted-by":"publisher","DOI":"10.1159\/000103486"},{"key":"S0033291700047966_ref015","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/105.1.1"},{"key":"S0033291700047966_ref019","first-page":"317","article-title":"On chorea","volume":"26","author":"Huntington","year":"1872","journal-title":"Medical and Surgical Reporter (Philadelphia)"},{"key":"S0033291700047966_ref023","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.84.348.21"},{"key":"S0033291700047966_ref012","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700050054"},{"key":"S0033291700047966_ref026","first-page":"155","article-title":"Clinical variability in the Marfan Syndrome(s)","volume":"15","author":"Pyeritz","year":"1979","journal-title":"Birth Defects: Orginal Article Series"},{"key":"S0033291700047966_ref005","volume-title":"Psychiatric Diagnosis in New York and London","author":"Cooper","year":"1972"},{"key":"S0033291700047966_ref002","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.116.532.259"},{"key":"S0033291700047966_ref029","doi-asserted-by":"crossref","first-page":"299","DOI":"10.5694\/j.1326-5377.1972.tb46796.x","article-title":"Huntington's Chorea in Queensland: a not uncommon disease","volume":"i","author":"Wallace","year":"1972","journal-title":"Medical Journal of Australia"},{"key":"S0033291700047966_ref025","unstructured":"Paterson M. C. , Bech-Hansen N. T. & Blattner W. A. (1982). Survey of human hereditary and familial disorders for gamma ray response in vitro: occurrence of both cellular radio-sensitivity and radio resistance in cancer-prone families. In The Proceedings of 1st Conference of Radio Protectors and Anticarcinogens Gaithersburg, Maryland, 21 June 1982. Academic Press: New York."},{"key":"S0033291700047966_ref010","first-page":"281","volume-title":"Advances in Neurology","volume":"23","author":"Folstein","year":"1979"},{"key":"S0033291700047966_ref021","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1974.tb08910.x"},{"key":"S0033291700047966_ref006","first-page":"195","article-title":"Huntington's Chorea in relation to heredity and eugenics","volume":"73","author":"Davenport","year":"1916","journal-title":"American Journal of Insanity"},{"key":"S0033291700047966_ref011","first-page":"104","article-title":"A phenocopy of Huntington's Disease: lacunar infarcts of the corpus striatum","volume":"148","author":"Folstein","year":"1981","journal-title":"Johns Hopkins Medical Journal"}],"container-title":["Psychological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0033291700047966","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T11:26:48Z","timestamp":1589974008000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0033291700047966\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,8]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1983,8]]}},"alternative-id":["S0033291700047966"],"URL":"https:\/\/doi.org\/10.1017\/s0033291700047966","relation":{},"ISSN":["0033-2917","1469-8978"],"issn-type":[{"value":"0033-2917","type":"print"},{"value":"1469-8978","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,8]]}}}