{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T15:02:17Z","timestamp":1697814137976},"reference-count":19,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,3,17]],"date-time":"2009-03-17T00:00:00Z","timestamp":1237248000000},"content-version":"unspecified","delay-in-days":10547,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Quart. Rev. Biophys."],"published-print":{"date-parts":[[1980,5]]},"abstract":"<jats:p>A bacterium incorporates amino acids into protein with an error frequency close to one in three thousand (Edelman &amp; Gallant, 1977). Nevertheless, the structural differences between related amino acids are so small that it is difficult to see how they can be distinguished from each other with such accuracy (see, for example, Pauling, 1958).<\/jats:p><jats:p>Indeed, the selection of amino acids during protein synthesis is carried out twice: first by the aminoacyl-tRNA synthetases and then by the codon-programmed ribosome. Each of these substrate selections is in fact a double selection. In the case of the synthetase both a particular amino acid and a corresponding cognate tRNA must be chosen to form the aminoacyl-tRNA. On the ribosome, the aminoacyl-tRNA must be matched with a cognate codon, and then the mRNA must be advanced by exactly one codon length to position the next codon in the appropriate ribosome site so that it too can be translated.<\/jats:p>","DOI":"10.1017\/s0033583500001669","type":"journal-article","created":{"date-parts":[[2009,3,17]],"date-time":"2009-03-17T16:11:50Z","timestamp":1237306310000},"page":"231-254","source":"Crossref","is-referenced-by-count":22,"title":["Free-energy dissipation constrainst on the accuracy of enzymatic selections"],"prefix":"10.1017","volume":"13","author":[{"given":"C.","family":"Blomberg","sequence":"first","affiliation":[]},{"given":"M.","family":"Ehrenberg","sequence":"additional","affiliation":[]},{"given":"C. G.","family":"Kurland","sequence":"additional","affiliation":[]}],"member":"56","published-online":{"date-parts":[[2009,3,17]]},"reference":[{"key":"S0033583500001669_ref013","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.72.11.4248"},{"key":"S0033583500001669_ref019","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6603(08)60134-8"},{"key":"S0033583500001669_ref001","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S0021-9258(18)96841-9","article-title":"Transfer ribonucleic acidinduced hydrolysis of valyladenylate bound to isoleucyl ribonucleic acid synthetase.","volume":"241","author":"Baldwin(Norris)","year":"1966","journal-title":"J. biol. Chem."},{"key":"S0033583500001669_ref006","first-page":"131","article-title":"Mistranslation in","volume":"10","author":"Edelman","year":"1977","journal-title":"E. coli. Cell"},{"key":"S0033583500001669_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/0303-2647(79)90003-0"},{"key":"S0033583500001669_ref003","unstructured":"Berg O. & Ehrenberg M. (1980). Concentration distributions around enzymes in the steady state. (Manuscript in preparation.)"},{"key":"S0033583500001669_ref004","unstructured":"Blomberg C. & Ehrenberg M. (1980 a). Energy considerations for kinetic proofreading in biosynthesis. J. theor. Biol. (Submitted.)"},{"key":"S0033583500001669_ref007","doi-asserted-by":"crossref","unstructured":"Ehrenberg M. & Blomberg C. (1980). Thermodynamic constraints on kinetic proofreading in biosynthetic pathways. Biophys J. (In the Press.)","DOI":"10.1016\/S0006-3495(80)85063-6"},{"key":"S0033583500001669_ref008","unstructured":"Glasstone S. , Laidler K. & Eyring H. (1941). The theory of rate processes (McGraw-Hill)."},{"key":"S0033583500001669_ref009","first-page":"261","article-title":"Ribosomal discrimination of tRNAs.","volume":"234","author":"Gorini","year":"1971","journal-title":"Nature"},{"key":"S0033583500001669_ref010","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.71.10.4135"},{"key":"S0033583500001669_ref011","doi-asserted-by":"publisher","DOI":"10.1126\/science.163.3874.1410"},{"key":"S0033583500001669_ref012","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(78)85494-0"},{"key":"S0033583500001669_ref014","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(74)90586-5"},{"key":"S0033583500001669_ref015","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9084(75)80139-8"},{"key":"S0033583500001669_ref016","first-page":"330","article-title":"Mechanism of aminoacyl RNA synthesis: studies with isolated aminoacyl adenylate complexes of isoleucyl RNA synthetase","volume":"52","author":"Norris","year":"1964","journal-title":"Biochemistry"},{"key":"S0033583500001669_ref017","first-page":"597","volume-title":"Festschrift Arthur Stoll","author":"Pauling","year":"1958"},{"key":"S0033583500001669_ref018","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(79)90364-4"},{"key":"S0033583500001669_ref005","volume-title":"Accuracy in Molecular Biology","author":"Blomberg","year":"1980"}],"container-title":["Quarterly Reviews of Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0033583500001669","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,3]],"date-time":"2021-10-03T09:22:26Z","timestamp":1633252946000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0033583500001669\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,5]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1980,5]]}},"alternative-id":["S0033583500001669"],"URL":"https:\/\/doi.org\/10.1017\/s0033583500001669","relation":{},"ISSN":["0033-5835","1469-8994"],"issn-type":[{"value":"0033-5835","type":"print"},{"value":"1469-8994","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,5]]}}}