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Its structure, which now looks so simple and habitual, then seemed to be unusually complicated. The decoding of the subsequent proteins, lysozyme (Blake<jats:italic>et al.<\/jats:italic>1965), ribonuclease (Kartha, Bello &amp; Harker, 1967), chymotrypsin (Matthews<jats:italic>et al.<\/jats:italic>1967), carboxypeptidase (Lipscomb<jats:italic>et al.<\/jats:italic>1969) redoubled the feeling of amazement and even of some confusion before the extremely complicated, intricate and, above all, absolutely unlike protein structures. Some consolation against this background was the evident and far-reaching similarity between the three-dimensional structures of myoglobin and hemoglobin subunits (Perutz, Kendrew &amp; Watson, 1965) and an analogous similarity between the structures of chymotrypsin and other serine proteases, elastase (Shotton &amp; Watson, 1970) and trypsin (Stroud, Kay &amp; Dickerson, 1972). 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