{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T07:46:39Z","timestamp":1767771999717},"reference-count":82,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,3,17]],"date-time":"2009-03-17T00:00:00Z","timestamp":1237248000000},"content-version":"unspecified","delay-in-days":9541,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Quart. Rev. Biophys."],"published-print":{"date-parts":[[1983,2]]},"abstract":"<jats:p>The experimental observations described in this article indicated that a distribution of many different fluctuations is present in a globular protein. These fluctuations were characterized by observation of many natural internal probes such as the labile peptide protons and the aromatic side chains. The conditions which are necessary to get reactions of the internal probes have been discussed in detail. The structural interpretation of the data was facilitated by the development and the use of new NMR techniques which provided the identification of the resonances of all the labile peptide protons. With NOE measurements a distinction between correlated and uncorrelated exchange events was obtained. This enabled us to elucidate the exchange mechanism over a wide range of p<jats:sup>2<\/jats:sup>H and temperature and to classify different subsets of fluctuations with respect to their lifetimes. It was further demonstrated that a change of external conditions such as temperature, p<jats:sup>2<\/jats:sup>H or pressure can change the distribution of fluctuations in the protein. The mechanisms responsible for rotation of internal aromatic side chains were also found to change with temperature, and mechanistic aspects of these fluctuations were discussed.<\/jats:p>","DOI":"10.1017\/s0033583500004911","type":"journal-article","created":{"date-parts":[[2009,3,17]],"date-time":"2009-03-17T16:01:52Z","timestamp":1237305712000},"page":"1-57","source":"Crossref","is-referenced-by-count":201,"title":["Characterization of the distribution of internal motions in the basic pancreatic trypsin inhibitor using a large number of internal NMR probes"],"prefix":"10.1017","volume":"16","author":[{"given":"Gerhard","family":"Wagner","sequence":"first","affiliation":[]}],"member":"56","published-online":{"date-parts":[[2009,3,17]]},"reference":[{"key":"S0033583500004911_ref051","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(79)90549-7"},{"key":"S0033583500004911_ref082","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(80)84989-7"},{"key":"S0033583500004911_ref080","unstructured":"W\u00fcthrich K. & Wagner G. (1982). NMR studies of concerted motions in the interior and on the surface of globular proteins. Proc. Ciba Fdn. Symp. on Internal Motions in Proteins, London (in the press)."},{"key":"S0033583500004911_ref055","doi-asserted-by":"publisher","DOI":"10.1021\/bi00688a008"},{"key":"S0033583500004911_ref071","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1979.tb12960.x"},{"key":"S0033583500004911_ref069","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1978.tb12538.x"},{"key":"S0033583500004911_ref065","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(82)90009-2"},{"key":"S0033583500004911_ref058","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9084(80)80101-5"},{"key":"S0033583500004911_ref079","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(79)90548-5"},{"key":"S0033583500004911_ref063","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(79)90550-3"},{"key":"S0033583500004911_ref041","doi-asserted-by":"publisher","DOI":"10.1002\/bip.1980.360190712"},{"key":"S0033583500004911_ref056","doi-asserted-by":"publisher","DOI":"10.1063\/1.436814"},{"key":"S0033583500004911_ref074","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(80)84990-3"},{"key":"S0033583500004911_ref072","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1981.tb05157.x"},{"key":"S0033583500004911_ref060","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(80)80198-0"},{"key":"S0033583500004911_ref021","doi-asserted-by":"publisher","DOI":"10.1021\/bi00593a013"},{"key":"S0033583500004911_ref052","doi-asserted-by":"publisher","DOI":"10.1021\/bi00564a006"},{"key":"S0033583500004911_ref042","doi-asserted-by":"publisher","DOI":"10.1063\/1.1699114"},{"key":"S0033583500004911_ref066","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(82)90180-2"},{"key":"S0033583500004911_ref050","doi-asserted-by":"publisher","DOI":"10.1007\/BF02906521"},{"key":"S0033583500004911_ref049","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bb.06.060177.001055"},{"key":"S0033583500004911_ref030","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-8914(40)90098-2"},{"key":"S0033583500004911_ref047","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(76)80132-9"},{"key":"S0033583500004911_ref043","doi-asserted-by":"publisher","DOI":"10.1021\/bi00752a003"},{"key":"S0033583500004911_ref017","doi-asserted-by":"publisher","DOI":"10.1038\/280558a0"},{"key":"S0033583500004911_ref020","doi-asserted-by":"publisher","DOI":"10.1007\/BF00863707"},{"key":"S0033583500004911_ref016","first-page":"107","article-title":"The activated complex in chemical reactions","volume":"3","author":"Eyring","year":"1935","journal-title":"J. chem."},{"key":"S0033583500004911_ref015","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.41.070172.004351"},{"key":"S0033583500004911_ref011","doi-asserted-by":"publisher","DOI":"10.1107\/S0567740875002415"},{"key":"S0033583500004911_ref078","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(78)94607-8"},{"key":"S0033583500004911_ref019","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3233(08)60459-3"},{"key":"S0033583500004911_ref007","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1016\/S0021-9258(19)62340-9","article-title":"Pressure effects on folded proteins in solution","volume":"253","author":"Carter","year":"1978","journal-title":"J. biol. Chem."},{"key":"S0033583500004911_ref001","doi-asserted-by":"publisher","DOI":"10.1038\/280563a0"},{"key":"S0033583500004911_ref014","doi-asserted-by":"publisher","DOI":"10.1002\/bip.1969.360070309"},{"key":"S0033583500004911_ref012","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2795(79)90020-5"},{"key":"S0033583500004911_ref057","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1971.tb01634.x"},{"key":"S0033583500004911_ref003","doi-asserted-by":"publisher","DOI":"10.1021\/bi00564a001"},{"key":"S0033583500004911_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(76)80734-X"},{"key":"S0033583500004911_ref032","volume-title":"Zahlemuerte und Funktionen, Transport-ph\u00e4nomene","volume":"I","author":"Landolt-B\u00f6rnstein","year":"1969"},{"key":"S0033583500004911_ref054","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(79)90400-5"},{"key":"S0033583500004911_ref004","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1978.tb12425.x"},{"key":"S0033583500004911_ref067","doi-asserted-by":"publisher","DOI":"10.1007\/BF00863706"},{"key":"S0033583500004911_ref010","doi-asserted-by":"publisher","DOI":"10.1016\/0079-6107(79)90030-0"},{"key":"S0033583500004911_ref064","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(79)90414-5"},{"key":"S0033583500004911_ref013","doi-asserted-by":"publisher","DOI":"10.1002\/anie.196400011"},{"key":"S0033583500004911_ref009","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.73.8.2740"},{"key":"S0033583500004911_ref006","doi-asserted-by":"publisher","DOI":"10.3109\/10409237509102555"},{"key":"S0033583500004911_ref044","doi-asserted-by":"publisher","DOI":"10.1021\/j100589a006"},{"key":"S0033583500004911_ref036","first-page":"55","article-title":"The mobile defect hypothesis of protein function","volume":"246","author":"Lumry","year":"1975","journal-title":"Coll. Int. C.N.R.S. L'Eau. Syst. Biol."},{"key":"S0033583500004911_ref033","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(71)90324-X"},{"key":"S0033583500004911_ref038","doi-asserted-by":"publisher","DOI":"10.1021\/bi00666a009"},{"key":"S0033583500004911_ref076","volume-title":"Nuclear Magnetic Resonance in Biological Research - Peptides and Proteins","author":"W\u00fcthrich","year":"1976"},{"key":"S0033583500004911_ref025","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(81)90343-0"},{"key":"S0033583500004911_ref068","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1978.tb12285.x"},{"key":"S0033583500004911_ref035","first-page":"2657","article-title":"Increase of 13C NMR relaxation times in proteins due to picosecond motional averaging","volume":"94","author":"Levy","year":"1981","journal-title":"J. Am. chem. Soc."},{"key":"S0033583500004911_ref008","doi-asserted-by":"publisher","DOI":"10.1038\/256705a0"},{"key":"S0033583500004911_ref039","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(73)80086-9"},{"key":"S0033583500004911_ref026","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1002\/bip.1980.360190712","article-title":"Dynamics of tyrosine ring rotations in a globular protein","volume":"19","author":"Karplus","year":"1980","journal-title":"Biopolymers"},{"key":"S0033583500004911_ref028","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(81)80881-2"},{"key":"S0033583500004911_ref031","doi-asserted-by":"publisher","DOI":"10.1088\/0034-4885\/29\/1\/306"},{"key":"S0033583500004911_ref034","doi-asserted-by":"publisher","DOI":"10.1038\/294379a0"},{"key":"S0033583500004911_ref037","doi-asserted-by":"publisher","DOI":"10.1021\/ja00381a010"},{"key":"S0033583500004911_ref040","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.8.3585"},{"key":"S0033583500004911_ref029","doi-asserted-by":"publisher","DOI":"10.1038\/296713a0"},{"key":"S0033583500004911_ref045","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1981.tb05156.x"},{"key":"S0033583500004911_ref073","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.5.1418"},{"key":"S0033583500004911_ref070","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1979.tb12959.x"},{"key":"S0033583500004911_ref022","doi-asserted-by":"publisher","DOI":"10.1021\/bi00519a027"},{"key":"S0033583500004911_ref027","doi-asserted-by":"publisher","DOI":"10.3109\/10409238109105437"},{"key":"S0033583500004911_ref059","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1016\/S0021-9258(18)97128-0","article-title":"On the conformational mobility of globular proteins","volume":"240","author":"Von Hippel","year":"1965","journal-title":"J. biol. Chem."},{"key":"S0033583500004911_ref077","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(75)80504-7"},{"key":"S0033583500004911_ref053","unstructured":"Roder H. (1981). Interne Mobilit\u00e4t in Proteinen unter nativen und denaturierenden Bedingungen: Untersuchung von Trypsin-Inhibitoren mil spektroskopischen Methoden. Ph.D. Thesis Nr. 6932, ETH Z\u00fcrich."},{"key":"S0033583500004911_ref023","doi-asserted-by":"publisher","DOI":"10.1016\/0968-0004(79)90298-6"},{"key":"S0033583500004911_ref081","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(80)90342-3"},{"key":"S0033583500004911_ref062","first-page":"261","article-title":"Internal mobility in globular proteins","volume":"I","author":"Wagner","year":"1982","journal-title":"Comments Mol. Cell. Biophys."},{"key":"S0033583500004911_ref075","doi-asserted-by":"crossref","unstructured":"Woodward C. , Simon I. & T\u00fcchsen E. (1982). Hydrogen exchange and the dynamic structure of proteins. Mol. & Cell. Biochem. (in press).","DOI":"10.1007\/BF00421225"},{"key":"S0033583500004911_ref018","doi-asserted-by":"publisher","DOI":"10.1063\/1.440485"},{"key":"S0033583500004911_ref024","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3233(08)60129-1"},{"key":"S0033583500004911_ref061","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(80)90308-3"},{"key":"S0033583500004911_ref046","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1515\/zpch-1932-1539","article-title":"Ueber die Geschwindigkeitskonstante von Austauschreaktionen","volume":"15","author":"Pelzer","year":"1932","journal-title":"Z. phys. Chem."},{"key":"S0033583500004911_ref002","doi-asserted-by":"publisher","DOI":"10.1021\/bi00695a021"},{"key":"S0033583500004911_ref048","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3233(08)60460-X"}],"container-title":["Quarterly Reviews of Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0033583500004911","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,3]],"date-time":"2021-10-03T09:20:12Z","timestamp":1633252812000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0033583500004911\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,2]]},"references-count":82,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1983,2]]}},"alternative-id":["S0033583500004911"],"URL":"https:\/\/doi.org\/10.1017\/s0033583500004911","relation":{},"ISSN":["0033-5835","1469-8994"],"issn-type":[{"value":"0033-5835","type":"print"},{"value":"1469-8994","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,2]]}}}