{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:25:58Z","timestamp":1761017158802,"version":"3.41.0"},"reference-count":17,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T00:00:00Z","timestamp":1442534400000},"content-version":"unspecified","delay-in-days":9087,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. j. neurol. sci."],"published-print":{"date-parts":[[1990,11]]},"abstract":"<jats:title>ABSTRACT:<\/jats:title><jats:p>The clinical histories and pathological findings of 27 autopsied cases of orthotopic liver transplantation (OLT) were reviewed. Fatal OLT was complicated in 93% of cases by neurological dysfunction, usually manifested by encephalopathy, with or without seizures. The etiology of the encephalopathy was largely multifactorial (44%) or undetermined (20%). Subarachnoid hemorrhage, central pontine myelinolysis, meningitis, brain infarction, polyclonal B cell lymphoma and spinal cord necrosis were common neuropathological findings. These diagnoses were often masked by other systemic illnesses. The role of cytomegalovirus (CMV) in neurologic dysfunction was explored with<jats:italic>in situ<\/jats:italic>hybridization and immunohistochemical techniques. OLT cases showed a significantly higher (89%) frequency of CMV genomic material in brain tissue compared to age-matched non immunocompromised (NIC) patients (23%). All OLT cases with encephalopathy of undetermined cause demonstrated unusually prominent hybridization to the CMV probe. CMV may be an important cause of encephalopathy in such patients.<\/jats:p>","DOI":"10.1017\/s0317167100030912","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T11:41:22Z","timestamp":1469706082000},"page":"378-381","source":"Crossref","is-referenced-by-count":24,"title":["Encephalopathy in Liver Transplantation: Neuropathology and CMV Infection"],"prefix":"10.1017","volume":"17","author":[{"given":"C.","family":"Power","sequence":"first","affiliation":[]},{"given":"S.D.","family":"Poland","sequence":"additional","affiliation":[]},{"given":"K.H.","family":"Kassim","sequence":"additional","affiliation":[]},{"given":"J.C.E.","family":"Kaufmann","sequence":"additional","affiliation":[]},{"given":"G.P.A.","family":"Rice","sequence":"additional","affiliation":[]}],"member":"56","published-online":{"date-parts":[[2015,9,18]]},"reference":[{"key":"S0317167100030912_ref016","first-page":"174","volume-title":"Current topics in infectious disease","author":"Ho","year":"1982"},{"key":"S0317167100030912_ref013","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410190603"},{"key":"S0317167100030912_ref012","first-page":"1","article-title":"Neuropathologic findings in the acquired immunodeficiency syndrome (AIDS)","volume":"5","author":"Anders","year":"1986","journal-title":"Clin Neuropathol"},{"key":"S0317167100030912_ref011","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198611000-00003"},{"key":"S0317167100030912_ref003","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(18)30873-9"},{"key":"S0317167100030912_ref001","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840080440"},{"key":"S0317167100030912_ref004","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198803000-00006"},{"key":"S0317167100030912_ref010","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.10.1297"},{"key":"S0317167100030912_ref015","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198603000-00003"},{"key":"S0317167100030912_ref005","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1097\/00005072-196507000-00004","article-title":"Neuropathological features of human organ transplantation I: Probable cytomegalovirus infection","volume":"24","author":"Schnede","year":"1965","journal-title":"J Neuropathol Exp Neurol"},{"key":"S0317167100030912_ref009","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.4049\/jimmunol.140.5.1625","article-title":"horbel ester-induce differentiation permits productive human cytomegalovirus infection in a monocytic cell line","volume":"140","author":"Weinshenker","year":"1988","journal-title":"J Immunol"},{"key":"S0317167100030912_ref017","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.19.6134"},{"key":"S0317167100030912_ref006","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.23.2.136"},{"key":"S0317167100030912_ref014","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/112.1.245"},{"key":"S0317167100030912_ref008","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(88)80182-5"},{"key":"S0317167100030912_ref007","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1983.tb00648.x"},{"key":"S0317167100030912_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)90294-7"}],"container-title":["Canadian Journal of Neurological Sciences \/ Journal Canadien des Sciences Neurologiques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0317167100030912","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T07:13:53Z","timestamp":1749021233000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0317167100030912\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,11]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1990,11]]}},"alternative-id":["S0317167100030912"],"URL":"https:\/\/doi.org\/10.1017\/s0317167100030912","relation":{},"ISSN":["0317-1671","2057-0155"],"issn-type":[{"type":"print","value":"0317-1671"},{"type":"electronic","value":"2057-0155"}],"subject":[],"published":{"date-parts":[[1990,11]]}}}