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MPTP or its metabolite enters nerve cells at the level of their terminals in the caudate nucleus and putamen leading to a disturbance in axoplasmic flow and retrograde degeneration. The species-dependent neurotoxicity of MPTP (primate vs. rodent) suggests that a biochemical property of the cell related to neuromelanin may be important in the mechanism of cell injury.<\/jats:p>","DOI":"10.1017\/s0317167100046345","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T11:36:04Z","timestamp":1469705764000},"page":"166-168","source":"Crossref","is-referenced-by-count":122,"title":["The Neurotoxicity of 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine in the Monkey and Man"],"prefix":"10.1017","volume":"11","author":[{"given":"R.","family":"Stanley Burns","sequence":"first","affiliation":[]},{"given":"Sanford P.","family":"Markey","sequence":"additional","affiliation":[]},{"given":"Jere M.","family":"Phillips","sequence":"additional","affiliation":[]},{"given":"Chuang C.","family":"Chiueh","sequence":"additional","affiliation":[]}],"member":"56","published-online":{"date-parts":[[2015,9,18]]},"reference":[{"key":"S0317167100046345_ref569","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/S0026-895X(25)13536-0","article-title":"Autoxidation verses covalent binding of quinones as the mechanism of toxicity of dopamine, 6-hydroxdopamine, and related compounds toward C 1300 neuroblastoma cells in vitro","volume":"14","author":"Graham","year":"1978","journal-title":"Mol. 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