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ETO involves tailoring products to meet specific customer requirements, often posing coordination challenges in integrating engineering and production. Meeting customer demands for short lead times without imposing high price premiums is a key industry challenge. This article explores the application of artificial neural networks as an enabler for design automation to deliver a first tentative optimal design solution in a short period of time with respect to more computationally demanding optimization methods. The research, conducted in collaboration with an energy company operating in the Oil &amp; Gas and energy transition markets, focuses on the design process of reciprocating compressors as a means of study to develop and validate the developed methodology. Three case studies corresponding to as many representative jobs related to reciprocating compressor cylinders have been analyzed. The results indicate that the proposed method performs well within its training boundaries, delivering optimal solutions and providing reasonably accurate predictions for target configurations beyond these boundaries. However, in cases requiring a creative redesign using artificial neural networks may lead to errors that exceed acceptable tolerance levels. In any case, this methodology can significantly assist design engineers in the efficient design of complex systems of components, resulting in reduced operating and lead times.<\/jats:p>","DOI":"10.1017\/s089006042510005x","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T08:37:31Z","timestamp":1750927051000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Machine learning as an enabler for design automation in engineering-to-order industry"],"prefix":"10.1017","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5445-3617","authenticated-orcid":false,"given":"Niccol\u00f2","family":"Batini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1641-3796","authenticated-orcid":false,"given":"Niccol\u00f2","family":"Becattini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1827-6454","authenticated-orcid":false,"given":"Gaetano","family":"Cascini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2025,6,26]]},"reference":[{"key":"S089006042510005X_r30","doi-asserted-by":"publisher","DOI":"10.1016\/j.apenergy.2008.06.006"},{"key":"S089006042510005X_r65","first-page":"137","article-title":"The new product development game","volume":"64","author":"Takeuchi","year":"1986","journal-title":"Harvard Business Review"},{"key":"S089006042510005X_r11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpe.2021.108274"},{"key":"S089006042510005X_r72","doi-asserted-by":"publisher","DOI":"10.1108\/IJOPM-07-2014-0339"},{"key":"S089006042510005X_r12","unstructured":"Cederfeldt, M (2007) Planning Design Automation: A Structured Method and Supporting Tools (Doctoral dissertation, Department of Product and Production Development, Chalmers University of Technology)."},{"key":"S089006042510005X_r28","doi-asserted-by":"publisher","DOI":"10.1016\/S1352-2310(97)00447-0"},{"key":"S089006042510005X_r19","doi-asserted-by":"publisher","DOI":"10.1017\/S0890060415000372"},{"key":"S089006042510005X_r56","unstructured":"Presley, A and Liles, DH (1995, May) The use of IDEF0 for the design and specification of methodologies. 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