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In contrast to quantitative methods that permit fine-grained (kinetic) analysis, qualitative approaches allow for addressing large-scale networks. This is accomplished by more abstract representations such as logical networks. We elaborate upon such a qualitative approach aiming at the computation of minimal interventions in logical signaling networks relying on Kleene's three-valued logic and fixpoint semantics. We address this problem within answer set programming and show that it greatly outperforms previous work using dedicated algorithms.<\/jats:p>","DOI":"10.1017\/s1471068413000422","type":"journal-article","created":{"date-parts":[[2013,9,25]],"date-time":"2013-09-25T16:24:58Z","timestamp":1380126298000},"page":"675-690","source":"Crossref","is-referenced-by-count":19,"title":["Minimal intervention strategies in logical signaling networks with ASP"],"prefix":"10.1017","volume":"13","author":[{"given":"ROLAND","family":"KAMINSKI","sequence":"first","affiliation":[]},{"given":"TORSTEN","family":"SCHAUB","sequence":"additional","affiliation":[]},{"given":"ANNE","family":"SIEGEL","sequence":"additional","affiliation":[]},{"given":"SANTIAGO","family":"VIDELA","sequence":"additional","affiliation":[]}],"member":"56","published-online":{"date-parts":[[2013,9,25]]},"reference":[{"key":"S1471068413000422_ref3","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511543357"},{"key":"S1471068413000422_ref32","doi-asserted-by":"publisher","DOI":"10.1021\/bi902202q"},{"key":"S1471068413000422_ref19","volume-title":"Proceedings of the Twenty-third International Joint Conference on Artificial Intelligence (IJCAI'13)","author":"Gebser","year":"2013"},{"key":"S1471068413000422_ref43","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.09.008"},{"key":"S1471068413000422_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/0022-5193(69)90015-0"},{"key":"S1471068413000422_ref31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000591"},{"key":"S1471068413000422_ref48","doi-asserted-by":"publisher","DOI":"10.1088\/1478-3975\/9\/5\/055001"},{"key":"S1471068413000422_ref33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000912"},{"key":"S1471068413000422_ref20","doi-asserted-by":"publisher","DOI":"10.1017\/S1471068410000554"},{"key":"S1471068413000422_ref41","doi-asserted-by":"publisher","DOI":"10.1186\/1759-4499-2-1"},{"key":"S1471068413000422_ref1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2000008"},{"key":"S1471068413000422_ref22","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-30743-0_23"},{"key":"S1471068413000422_ref29","first-page":"1950","volume-title":"Introduction to Metamathematics","author":"Kleene","year":"1950"},{"key":"S1471068413000422_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.automatica.2007.08.004"},{"key":"S1471068413000422_ref7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000702"},{"key":"S1471068413000422_ref28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000385"},{"key":"S1471068413000422_ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2003.08.001"},{"key":"S1471068413000422_ref36","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-4453"},{"key":"S1471068413000422_ref45","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-33636-2_20"},{"key":"S1471068413000422_ref4","unstructured":"Baral C. , Chancellor K. , Tran N. , Tran N. , Joy A. and Berens M. 2004. 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