{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T21:45:33Z","timestamp":1747172733319,"version":"3.40.5"},"reference-count":9,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T00:00:00Z","timestamp":1636502400000},"content-version":"unspecified","delay-in-days":313,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ASHE"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S2732494X2100187X_as1\">\n\t    <jats:title>Background:<\/jats:title>\n\t    <jats:p>The pandemic caused by severe acute respiratory coronavirus virus 2 (SARS-CoV-2) has dramatically increased cheshospitalizations, and it is often difficult to determine whether there is a bacterial or fungal coinfection at time of presentation. In this study, we sought to determine the rates of coinfection and utilization of antibiotics in SARS-CoV-2 disease.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X2100187X_as2\">\n\t    <jats:title>Methods:<\/jats:title>\n\t    <jats:p>Retrospective chart review of patients hospitalized with COVID-19 pneumonia from April 13, 2020, to July 14, 2020.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X2100187X_as3\">\n\t    <jats:title>Results:<\/jats:title>\n\t    <jats:p>In total, 277 patients were hospitalized for COVID-19 pneumonia during this period. Patients that received antibiotics within 48 hours of presentation were more likely to be febrile (59.3% vs 41.2%; <jats:italic>P<\/jats:italic> = .01) and to have leukocytosis (23.9% vs 5.9%; <jats:italic>P<\/jats:italic> &lt; .01) and were less likely to have a procalcitonin level &lt;0.25 ng\/mL (58.8% vs 74.5%; <jats:italic>P<\/jats:italic> = .04). In total, 45 patients had positive blood cultures collected during hospitalization, 16 of which were clinically significant. Of the clinically significant blood cultures, 5 were collected &lt;48 hours of admission. Moreover, 18 sputum cultures were clinically significant, 2 of which were collected within 48 hours of admission.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X2100187X_as4\">\n\t    <jats:title>Conclusion:<\/jats:title>\n\t    <jats:p>Bacterial and fungal coinfections in COVID-19 appear to be rare on presentation; thus, this factor may be a good target for enhanced antibiotic stewardship.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/ash.2021.187","type":"journal-article","created":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T08:27:23Z","timestamp":1636532843000},"source":"Crossref","is-referenced-by-count":0,"title":["Bacterial coinfections with coronavirus disease 2019 (COVID-19)"],"prefix":"10.1017","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9374-2155","authenticated-orcid":false,"given":"Glen","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Furukawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryant D.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian J.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur C.","family":"Jeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2021,11,10]]},"reference":[{"key":"S2732494X2100187X_ref5","doi-asserted-by":"publisher","DOI":"10.7326\/M20-2189"},{"key":"S2732494X2100187X_ref4","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkaa326"},{"key":"S2732494X2100187X_ref9","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S173867"},{"key":"S2732494X2100187X_ref2","article-title":"COVID-19, superinfections and antimicrobial development: What can we expect?","author":"Clancy","year":"2020","journal-title":"Clin Infect Dis"},{"key":"S2732494X2100187X_ref7","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2020.381"},{"key":"S2732494X2100187X_ref3","article-title":"Impact of COVID-19 on pneumonia-focused antibiotic use at an academic medical center","author":"Nestler","year":"2020","journal-title":"Infect Control Hosp Epidemiol"},{"key":"S2732494X2100187X_ref8","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1239"},{"key":"S2732494X2100187X_ref6","unstructured":"6. Clinical management of COVID-19. World Health Organization website. https:\/\/www.who.int\/publications\/i\/item\/clinical-management-of-covid-19. Accessed September 6, 2020."},{"key":"S2732494X2100187X_ref1","unstructured":"1. COVID-19 dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU). Johns Hopkins Universty website. https:\/\/coronavirus.jhu.edu\/map.html. Accessed January 24, 2021."}],"container-title":["Antimicrobial Stewardship &amp; Healthcare Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S2732494X2100187X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T08:27:28Z","timestamp":1636532848000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S2732494X2100187X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":9,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021]]}},"alternative-id":["S2732494X2100187X"],"URL":"https:\/\/doi.org\/10.1017\/ash.2021.187","relation":{},"ISSN":["2732-494X"],"issn-type":[{"type":"electronic","value":"2732-494X"}],"subject":[],"published":{"date-parts":[[2021]]},"article-number":"e45"}}