{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T15:36:21Z","timestamp":1781624181597,"version":"3.54.5"},"reference-count":21,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"unspecified","delay-in-days":306,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ASHE"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S2732494X21002151_as1\">\n\t    <jats:title>Objective:<\/jats:title>\n\t    <jats:p>Vancomycin-resistant <jats:italic>Enterococcus<\/jats:italic> (VRE) infections have been associated with increased mortality and poor outcomes. VRE screening has been used to identify colonized patients to prevent transmission; however, little is known about the utility of screening results to guide antibiotic therapy.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X21002151_as2\">\n\t    <jats:title>Design and setting:<\/jats:title>\n\t    <jats:p>A retrospective review was performed at a tertiary-care center between June 1, 2015, and May 31, 2018.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X21002151_as3\">\n\t    <jats:title>Patients:<\/jats:title>\n\t    <jats:p>All patients who underwent VRE polymerase chain reaction assay (PCR) screening and had a bacterial culture from 7 days before to 90 days after the screening test were included. In total, 1,374 patients who had a VRE screening test met inclusion criteria.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X21002151_as4\">\n\t    <jats:title>Methods:<\/jats:title>\n\t    <jats:p>Sensitivity, specificity, and positive and negative predictive values of VRE screening for VRE infection were calculated. The appropriateness of the antibiotic therapy for each patient based on screening results was also assessed.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X21002151_as5\">\n\t    <jats:title>Results:<\/jats:title>\n\t    <jats:p>We detected no difference in the appropriateness of antibiotic therapy between patients with a positive screen and those with a negative screen (59.3% vs 61.0%; <jats:italic>P<\/jats:italic> = .8657). The VRE PCR demonstrated 54% sensitivity, 89% specificity, a positive predictive value (PPV) of 13% and a negative predictive value (NPV) of 98%.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X21002151_as6\">\n\t    <jats:title>Conclusions:<\/jats:title>\n\t    <jats:p>The high NPV and specificity indicate that patients with a negative VRE screening results may not require empiric antibiotic coverage for VRE. Although VRE screening may have utility to detect colonization in high-risk patients, a positive VRE screen is of limited value in determining the need for an antibiotic with VRE culture-directed coverage.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/ash.2021.215","type":"journal-article","created":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T09:59:04Z","timestamp":1635933544000},"source":"Crossref","is-referenced-by-count":9,"title":["Impact of a vancomycin-resistant <i>Enterococcus<\/i> (VRE) screening result on appropriateness of antibiotic therapy"],"prefix":"10.1017","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1591-3681","authenticated-orcid":false,"given":"Jenna L.","family":"Reynolds","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raelene E.","family":"Trudeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Seville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2021,11,3]]},"reference":[{"key":"S2732494X21002151_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2014.06.024"},{"key":"S2732494X21002151_ref11","doi-asserted-by":"publisher","DOI":"10.1086\/502199"},{"key":"S2732494X21002151_ref9","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofw246"},{"key":"S2732494X21002151_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2008.10.010"},{"key":"S2732494X21002151_ref18","doi-asserted-by":"publisher","DOI":"10.1086\/510624"},{"key":"S2732494X21002151_ref4","doi-asserted-by":"publisher","DOI":"10.1086\/339211"},{"key":"S2732494X21002151_ref1","doi-asserted-by":"publisher","DOI":"10.1086\/593956"},{"key":"S2732494X21002151_ref17","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105103441903"},{"key":"S2732494X21002151_ref6","doi-asserted-by":"publisher","DOI":"10.1086\/342904"},{"key":"S2732494X21002151_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2012.01.009"},{"key":"S2732494X21002151_ref14","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000000203"},{"key":"S2732494X21002151_ref16","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2019.380"},{"key":"S2732494X21002151_ref12","doi-asserted-by":"publisher","DOI":"10.1086\/502924"},{"key":"S2732494X21002151_ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-014-0678-1"},{"key":"S2732494X21002151_ref20","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V124.21.6009.6009"},{"key":"S2732494X21002151_ref21","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw110"},{"key":"S2732494X21002151_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2007.10.007"},{"key":"S2732494X21002151_ref15","doi-asserted-by":"publisher","DOI":"10.9778\/cmajo.20170034"},{"key":"S2732494X21002151_ref19","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200102000-00016"},{"key":"S2732494X21002151_ref5","doi-asserted-by":"publisher","DOI":"10.1086\/427512"},{"key":"S2732494X21002151_ref2","doi-asserted-by":"publisher","DOI":"10.1086\/668770"}],"container-title":["Antimicrobial Stewardship &amp; Healthcare Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S2732494X21002151","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T09:59:06Z","timestamp":1635933546000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S2732494X21002151\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021]]}},"alternative-id":["S2732494X21002151"],"URL":"https:\/\/doi.org\/10.1017\/ash.2021.215","relation":{},"ISSN":["2732-494X"],"issn-type":[{"value":"2732-494X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]},"article-number":"e41"}}