{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T20:25:45Z","timestamp":1791663945736,"version":"4.3.4"},"reference-count":37,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T00:00:00Z","timestamp":1657756800000},"content-version":"unspecified","delay-in-days":194,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ASHE"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S2732494X22002443_as1\">\n\t    <jats:title>Objective:<\/jats:title>\n\t    <jats:p>To identify important risk factors for carbapenem-resistant Enterobacterales (CRE) infections among hospitalized patients.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X22002443_as2\">\n\t    <jats:title>Design:<\/jats:title>\n\t    <jats:p>We utilized a case\u2013case\u2013control design that compared patients with CRE infections to patients with carbapenem-susceptible Enterobacterales (CSE) infections and randomly selected controls during the period from January 2011 through December 2016.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X22002443_as3\">\n\t    <jats:title>Setting:<\/jats:title>\n\t    <jats:p>The study population was selected from patients at a large metropolitan tertiary-care and instructional medical center.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X22002443_as4\">\n\t    <jats:title>Patients:<\/jats:title>\n\t    <jats:p>Cases of CRE were defined as initial admission of adults diagnosed with a bacterial infection of an Enterobacterales species resistant clinically or through sensitivity testing to carbapenems 48 hours or more after admission. Cases of CSE were selected from the same patient population as the CRE cases within a 30-day window for admission, with diagnostic pathogens identified as susceptible to carbapenems. Controls were defined as adult patients admitted to any service within a 30-day window from a CRE case for &gt;48 hours who did not meet either of the above case definitions during that admission.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X22002443_as5\">\n\t    <jats:title>Results:<\/jats:title>\n\t    <jats:p>Antibiotic exposure within 90 days prior to admission and length of hospital stay were both associated with increased odds of CRE and CSE infections compared to controls. Patients with CRE infections had &gt;18 times greater odds of prior antibiotic exposure compared to patients with CSE infections.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X22002443_as6\">\n\t    <jats:title>Conclusions:<\/jats:title>\n\t    <jats:p>Antibiotic exposure and increased length of hospital stay may result in increased patient risk of developing an infection resistant to carbapenems and other \u03b2-lactams.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/ash.2022.244","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T06:03:47Z","timestamp":1657778627000},"source":"Crossref","is-referenced-by-count":8,"title":["Case\u2013case\u2013control study of risk factors for carbapenem-resistant Enterobacterales infections among hospitalized patients"],"prefix":"10.1017","volume":"2","author":[{"given":"David M.","family":"Stuever","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy K.","family":"Ferketich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8936-1555","authenticated-orcid":false,"given":"Jiyoung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt B.","family":"Stevenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9216-1308","authenticated-orcid":false,"given":"Thomas E.","family":"Wittum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2022,7,14]]},"reference":[{"key":"S2732494X22002443_ref36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078906"},{"key":"S2732494X22002443_ref28","doi-asserted-by":"publisher","DOI":"10.1086\/666642"},{"key":"S2732494X22002443_ref29","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-13-80"},{"key":"S2732494X22002443_ref16","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr156"},{"key":"S2732494X22002443_ref1","unstructured":"1. Drug resistance biggest threats. Centers for Disease Control and Prevention website. https:\/\/www.cdc.gov\/drugresistance\/biggest-threats.html. Published 2019. 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Carbapenemase-producing carbapenem-resistant Enterobacteriaceae (CP-CRE) 2018 case definition. Centers for Disease Control and Prevention website. https:\/\/wwwn.cdc.gov\/nndss\/conditions\/carbapenemase-producing-carbapenem-resistant-enterobacteriaceae\/case-definition\/2018\/. Published 2018. Accessed August 20, 2019."}],"container-title":["Antimicrobial Stewardship &amp; Healthcare Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S2732494X22002443","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T06:03:54Z","timestamp":1657778634000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S2732494X22002443\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":37,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022]]}},"alternative-id":["S2732494X22002443"],"URL":"https:\/\/doi.org\/10.1017\/ash.2022.244","relation":{},"ISSN":["2732-494X"],"issn-type":[{"value":"2732-494X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]},"article-number":"e118"}}