{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T21:43:50Z","timestamp":1747172630382,"version":"3.40.5"},"reference-count":38,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T00:00:00Z","timestamp":1647993600000},"content-version":"unspecified","delay-in-days":81,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ASHE"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S2732494X22000316_as1\">\n\t    <jats:title>Objective:<\/jats:title>\n\t    <jats:p>Patients on dialysis are at high risk for severe COVID-19 and associated morbidity and mortality. We examined the humoral response to SARS-CoV-2 mRNA vaccine BNT162b2 in a maintenance dialysis population.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X22000316_as2\">\n\t    <jats:title>Design:<\/jats:title>\n\t    <jats:p>Single-center cohort study.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X22000316_as3\">\n\t    <jats:title>Setting and participants:<\/jats:title>\n\t    <jats:p>Adult maintenance dialysis patients at 3 outpatient dialysis units of a large academic center.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X22000316_as4\">\n\t    <jats:title>Methods:<\/jats:title>\n\t    <jats:p>Participants were vaccinated with 2 doses of BNT162b2, 3 weeks apart. We assessed anti\u2013SARS-CoV-2 spike antibodies (anti-S) \u223c4\u20137 weeks after the second dose and evaluated risk factors associated with insufficient response. Definitions of antibody response are as follows: nonresponse (anti-S level, &lt;50 AU\/mL), low response (anti-S level, 50\u2013839 AU\/mL), and sufficient response (anti-S level, \u2265840 AU\/mL).<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X22000316_as5\">\n\t    <jats:title>Results:<\/jats:title>\n\t    <jats:p>Among the 173 participants who received 2 vaccine doses, the median age was 60 years (range, 28\u201388), 53.2% were men, 85% were of Black race, 86% were on in-center hemodialysis and 14% were on peritoneal dialysis. Also, 7 participants (4%) had no response, 27 (15.6%) had a low response, and 139 (80.3%) had a sufficient antibody response. In multivariable analysis, factors significantly associated with insufficient antibody response included end-stage renal disease comorbidity index score \u22655 and absence of prior hepatitis B vaccination response.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X22000316_as6\">\n\t    <jats:title>Conclusions:<\/jats:title>\n\t    <jats:p>Although most of our study participants seroconverted after 2 doses of BNT162b2, 20% of our cohort did not achieve sufficient humoral response. Our findings demonstrate the urgent need for a more effective vaccine strategy in this high-risk patient population and highlight the importance of ongoing preventative measures until protective immunity is achieved.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/ash.2022.31","type":"journal-article","created":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T12:45:37Z","timestamp":1648039537000},"source":"Crossref","is-referenced-by-count":3,"title":["Predictors of humoral response to SARS-CoV-2 mRNA vaccine BNT162b2 in patients receiving maintenance dialysis"],"prefix":"10.1017","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7331-9619","authenticated-orcid":false,"given":"Tingting","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1482-0854","authenticated-orcid":false,"given":"Sumanth","family":"Gandra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly A.","family":"Reske","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7070-9320","authenticated-orcid":false,"given":"Margaret A.","family":"Olsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvana","family":"Bommarito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Candace","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl G.","family":"Hock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire A.","family":"Ballman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0968-9409","authenticated-orcid":false,"given":"Christina","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7458-1264","authenticated-orcid":false,"given":"Na","family":"Le Dang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennie H.","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8679-8241","authenticated-orcid":false,"given":"David K.","family":"Warren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6251-0733","authenticated-orcid":false,"given":"Victoria J.","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher W.","family":"Farnsworth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the Centers for Disease Control and Prevention Epicenters Program","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2022,3,23]]},"reference":[{"key":"S2732494X22000316_ref19","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01325-6"},{"key":"S2732494X22000316_ref24","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.06450521"},{"key":"S2732494X22000316_ref15","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2021.01.003"},{"key":"S2732494X22000316_ref23","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2021.06.002"},{"key":"S2732494X22000316_ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2034577"},{"key":"S2732494X22000316_ref13","unstructured":"13. 2010 USRDS annual data report: atlas of end-stage renal disease in the United States. 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