{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T16:48:01Z","timestamp":1756572481951,"version":"3.40.5"},"reference-count":44,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T00:00:00Z","timestamp":1678320000000},"content-version":"unspecified","delay-in-days":67,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ASHE"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S2732494X23001328_as1\">\n\t    <jats:title>Background:<\/jats:title>\n\t    <jats:p>No established guidelines exist regarding the role of oral antibiotic therapy (OAT) to treat bloodstream infections (BSIs), and practices may vary depending on clinician specialty and experience.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X23001328_as2\">\n\t    <jats:title>Objective:<\/jats:title>\n\t    <jats:p>To assess practice patterns regarding oral antibiotic use for treatment of bacteremia in infectious diseases clinicians (IDCs, including physicians and pharmacists and trainees in these groups) and non\u2013infectious diseases clinicians (NIDCs).<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X23001328_as3\">\n\t    <jats:title>Design:<\/jats:title>\n\t    <jats:p>Open-access survey.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X23001328_as4\">\n\t    <jats:title>Participants:<\/jats:title>\n\t    <jats:p>Clinicians caring for hospitalized patients receiving antibiotics.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X23001328_as5\">\n\t    <jats:title>Methods:<\/jats:title>\n\t    <jats:p>An open-access, web-based survey was distributed to clinicians at a Midwestern academic medical center using e-mail and to clinicians outside the medical center using social media. Respondents answered questions regarding confidence prescribing OAT for BSI in different scenarios. We used \u03c72 analysis for categorical data evaluated association between responses and demographic groups.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X23001328_as6\">\n\t    <jats:title>Results:<\/jats:title>\n\t    <jats:p>Of 282 survey responses, 82.6% of respondents were physicians, 17.4% pharmacists, and IDCs represented 69.2% of all respondents. IDCs were more likely to select routine use of OAT for BSI due to gram-negative anaerobes (84.6% vs 59.8%; P &lt; .0001), Klebsiella spp (84.5% vs 69.0%; P &lt; .009), Proteus spp (83.6% vs 71.3%; P &lt; .027), and other Enterobacterales (79.5% vs 60.9%; P &lt; .004). Our survey results revealed significant differences in selected treatment of Staphylococcus aureus syndromes. Fewer IDCs than NIDCs selected OAT to complete treatment for methicillin-resistant S. aureus (MRSA) BSI due to gluteal abscess (11.9% vs 25.6%; P = .012) and methicillin-susceptible S. aureus (MSSA) BSI due to septic arthritis (13.9% vs 20.9%; P = .219).<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X23001328_as7\">\n\t    <jats:title>Conclusions:<\/jats:title>\n\t    <jats:p>Practice variation and discordance with evidence for the use of OAT for BSIs exists among IDCs versus NIDCs, highlighting opportunities for education in both clinician groups.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/ash.2023.132","type":"journal-article","created":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T08:24:54Z","timestamp":1678350294000},"source":"Crossref","is-referenced-by-count":2,"title":["Impact of specialty on the self-reported practice of using oral antibiotic therapy for definitive treatment of bloodstream infections"],"prefix":"10.1017","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0504-753X","authenticated-orcid":false,"given":"Jasmine R.","family":"Marcelin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mackenzie R.","family":"Keintz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4761-9607","authenticated-orcid":false,"given":"Jihyun","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9928-4546","authenticated-orcid":false,"given":"Trevor C.","family":"Van Schooneveld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7656-2569","authenticated-orcid":false,"given":"Bryan T.","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6466-9518","authenticated-orcid":false,"given":"Scott J.","family":"Bergman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Molly M.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8324-6414","authenticated-orcid":false,"given":"Erica J.","family":"Stohs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2023,3,9]]},"reference":[{"key":"S2732494X23001328_ref39","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1710926"},{"key":"S2732494X23001328_ref12","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofz386"},{"key":"S2732494X23001328_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2019.07.026"},{"key":"S2732494X23001328_ref26","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu296"},{"key":"S2732494X23001328_ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2016.07.029"},{"key":"S2732494X23001328_ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2021.10.007"},{"key":"S2732494X23001328_ref38","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1808312"},{"key":"S2732494X23001328_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2021.106451"},{"key":"S2732494X23001328_ref20","doi-asserted-by":"publisher","DOI":"10.1177\/106002809603000605"},{"key":"S2732494X23001328_ref6","first-page":"20499361211073248","article-title":"Evaluation of step-down oral antibiotic therapy for uncomplicated streptococcal bloodstream infections on clinical outcomes","volume":"9","author":"Kang","year":"2022","journal-title":"Ther Adv Infect Dis"},{"key":"S2732494X23001328_ref31","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.21048"},{"key":"S2732494X23001328_ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2014.05.004"},{"key":"S2732494X23001328_ref25","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofz364"},{"key":"S2732494X23001328_ref7","first-page":"2049936119863013","article-title":"Effectiveness of oral antibiotics for definitive therapy of non-staphylococcal gram-positive bacterial bloodstream infections","volume":"6","author":"Quinn","year":"2019","journal-title":"Ther Adv Infect Dis"},{"key":"S2732494X23001328_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2017.12.007"},{"key":"S2732494X23001328_ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2010.01.015"},{"key":"S2732494X23001328_ref5","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2024"},{"key":"S2732494X23001328_ref11","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki355"},{"key":"S2732494X23001328_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2022.08.024"},{"key":"S2732494X23001328_ref10","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dky452"},{"key":"S2732494X23001328_ref42","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw470"},{"key":"S2732494X23001328_ref14","doi-asserted-by":"publisher","DOI":"10.1080\/01421590802061613"},{"key":"S2732494X23001328_ref41","doi-asserted-by":"publisher","DOI":"10.1086\/520182"},{"key":"S2732494X23001328_ref43","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofz490"},{"key":"S2732494X23001328_ref9","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02345-19"},{"key":"S2732494X23001328_ref1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12144"},{"key":"S2732494X23001328_ref15","unstructured":"15. Marcelin, JR. UNMC ID Blog: Are you ever involved with prescribing antibiotics in the hospital? We want to hear from you! University of Nebraska Medical Center website. https:\/\/blog.unmc.edu\/infectious-disease\/2019\/11\/14\/are-you-ever-involved-with-prescribing-antibiotics-in-the-hospital-we-want-to-hear-from-you\/. Published November 14, 2019. Accessed March 1, 2022."},{"key":"S2732494X23001328_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2016.07.013"},{"key":"S2732494X23001328_ref30","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofz495"},{"key":"S2732494X23001328_ref37","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-020-4102-0"},{"key":"S2732494X23001328_ref44","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofab434"},{"key":"S2732494X23001328_ref13","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.20166"},{"key":"S2732494X23001328_ref29","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ120"},{"key":"S2732494X23001328_ref35","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.9743"},{"key":"S2732494X23001328_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2007.09.002"},{"key":"S2732494X23001328_ref22","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix648"},{"key":"S2732494X23001328_ref24","doi-asserted-by":"publisher","DOI":"10.1093\/jacamr\/dlac005"},{"key":"S2732494X23001328_ref8","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01515-20"},{"key":"S2732494X23001328_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2019.03.013"},{"key":"S2732494X23001328_ref27","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa039"},{"key":"S2732494X23001328_ref16","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix767"},{"key":"S2732494X23001328_ref21","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2018.6226"},{"key":"S2732494X23001328_ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2021.106329"},{"key":"S2732494X23001328_ref36","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq146"}],"container-title":["Antimicrobial Stewardship &amp; Healthcare Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S2732494X23001328","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T08:25:02Z","timestamp":1678350302000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S2732494X23001328\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023]]}},"alternative-id":["S2732494X23001328"],"URL":"https:\/\/doi.org\/10.1017\/ash.2023.132","relation":{},"ISSN":["2732-494X"],"issn-type":[{"type":"electronic","value":"2732-494X"}],"subject":[],"published":{"date-parts":[[2023]]},"article-number":"e48"}}