{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T08:47:13Z","timestamp":1771663633452,"version":"3.50.1"},"reference-count":25,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T00:00:00Z","timestamp":1681171200000},"content-version":"unspecified","delay-in-days":100,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ASHE"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S2732494X23001481_as1\">\n\t    <jats:title>Objective:<\/jats:title>\n\t    <jats:p>Hospital-acquired infection (HAI) rates were negatively affected by the the coronavirus disease 2019 (COVID-19) pandemic. We describe the incidence of HAIs, main pathogens, and multidrug-resistant organisms (MDROs) isolated in cancer patients before and during the pandemic.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X23001481_as2\">\n\t    <jats:title>Design:<\/jats:title>\n\t    <jats:p>This retrospective, comparative study included patients with HAIs. We compared 2 periods: the prepandemic period (2018, 2019, and the first 3 months of 2020) with the pandemic period (April\u2013December 2020 and all of 2021).<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X23001481_as3\">\n\t    <jats:title>Setting:<\/jats:title>\n\t    <jats:p>Instituto Nacional de Cancerolog\u00eda, a tertiary-care oncology public hospital in Mexico City, Mexico.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X23001481_as4\">\n\t    <jats:title>Methods:<\/jats:title>\n\t    <jats:p>Patients with the following HAIs were included: nosocomial pneumonia, ventilator-associated pneumonia (VAP), secondary bloodstream infection (BSI), central-line\u2013associated bloodstream infection (CLBSI), and <jats:italic>Clostridioides difficile<\/jats:italic> infection (CDI). Demographic data, clinical characteristics, pathogens isolated, and MDRO data were included.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X23001481_as5\">\n\t    <jats:title>Results:<\/jats:title>\n\t    <jats:p>We identified 639 HAIs: 381 (7.95 per 100 hospital discharges) in the prepandemic period and 258 (7.17 per 100 hospital discharges) in the pandemic period. Hematologic malignancy was documented in 263 (44.3%) patients; 251 (39.2%) were in cancer progression or relapse. Nosocomial pneumonia was more frequent during the pandemic period (40.3% vs 32.3%; <jats:italic>P<\/jats:italic> = .04). Total episodes of VAP were not different between the 2 periods (28.1% vs 22.1%; <jats:italic>P<\/jats:italic> = .08), but during the pandemic period, the VAP rate was higher among COVID-19 patients than non\u2013COVID-19 patients (72.2% vs 8.8%; <jats:italic>P<\/jats:italic> &lt; .001). <jats:italic>Escherichia coli<\/jats:italic>, <jats:italic>Stenotrophomonas maltophilia,<\/jats:italic> and <jats:italic>Staphylococcus aureus<\/jats:italic> bacteremia cases were more frequent in the pandemic period. Extended-spectrum \u03b2-lactamases (ESBL)\u2013<jats:italic>E. coli<\/jats:italic> was the only MDRO that occurred more frequently during the pandemic period.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X23001481_as6\">\n\t    <jats:title>Conclusions:<\/jats:title>\n\t    <jats:p>In cancer patients, nosocomial pneumonia was more frequent during the pandemic period. We did not observe a significant impact on other HAIs. MDROs did not significantly increase during the pandemic.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/ash.2023.148","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T12:40:41Z","timestamp":1681216841000},"source":"Crossref","is-referenced-by-count":5,"title":["Impact of coronavirus disease 2019 (COVID-19) pandemic in hospital-acquired infections and bacterial resistance at an oncology hospital"],"prefix":"10.1017","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6331-8372","authenticated-orcid":false,"given":"Patricia","family":"Cornejo-Ju\u00e1rez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1991-0923","authenticated-orcid":false,"given":"Patricia","family":"Volkow-Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla L.","family":"V\u00e1zquez-Mar\u00edn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"\u00c1lvarez-Romero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertha","family":"Garc\u00eda-Pineda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania","family":"Chavez-Chavez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8564-8735","authenticated-orcid":false,"given":"Diana","family":"Vilar-Compte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2023,4,11]]},"reference":[{"key":"S2732494X23001481_ref20","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18031003"},{"key":"S2732494X23001481_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2021.04.002"},{"key":"S2732494X23001481_ref3","first-page":"1","article-title":"The impact of coronavirus disease 2019 (COVID-19) on healthcare-associated infections in 2020: a summary of data reported to the National Healthcare Safety Network","volume":"43","author":"Weiner-Lastinger","year":"2021","journal-title":"Infect Control Hosp Epidemiol"},{"key":"S2732494X23001481_ref4","unstructured":"4. National Healthcare Safety Network. Pneumonia (ventilator-associated [VAP] and non\u2013ventilator-associated pneumonia [PNEU]) event. Centers for Disease Control and Prevention website. https:\/\/www.cdc.gov\/nhsn\/pdfs\/pscmanual\/6pscvapcurrent.pdf. Published January 2023. Accessed March 23, 2023."},{"key":"S2732494X23001481_ref19","doi-asserted-by":"publisher","DOI":"10.21037\/apm-21-833"},{"key":"S2732494X23001481_ref5","unstructured":"5. National Healthcare Safety Network (NHSN). Bloodstream infection event (central line-associated bloodstream infection and non\u2013central-line\u2013associated bloodstream infection. Centers for Disease Control and Prevention website. https:\/\/www.cdc.gov\/nhsn\/pdfs\/pscmanual\/4psc_clabscurrent.pdf. Published January 2023. Accessed March 23, 2023."},{"key":"S2732494X23001481_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2020.06.209"},{"key":"S2732494X23001481_ref9","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1200\/CCI.20.00134","article-title":"Impact of COVID-19 on cancer care: how the pandemic is delaying cancer diagnosis and treatment for American seniors","volume":"4","author":"Patt","year":"2020","journal-title":"JCO Clin Cancer Inform"},{"key":"S2732494X23001481_ref12","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-021-00959-y"},{"key":"S2732494X23001481_ref6","unstructured":"6. National Healthcare Safety Network (NHSN). CDC\/NHSN Surveillance definitions for specific types of infections. Centers for Disease Control and Prevention website. https:\/\/www.cdc.gov\/nhsn\/pdfs\/pscmanual\/17pscnosinfdef_current.pdf. Published January 2023. Accessed March 23, 2023."},{"key":"S2732494X23001481_ref13","doi-asserted-by":"crossref","first-page":"e315","DOI":"10.1016\/j.chest.2021.04.074","article-title":"High incidence of nosocomial infections in COVID-19 patients: is SARS-CoV-2 the culprit?","volume":"160","author":"Rouz\u00e9","year":"2021","journal-title":"Chest"},{"key":"S2732494X23001481_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2021.106324"},{"key":"S2732494X23001481_ref22","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s10096-020-04142-w","article-title":"Nosocomial infections associated to COVID-19 in the intensive care unit: clinical characteristics and outcome","volume":"40","author":"Bardi","year":"2021","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"S2732494X23001481_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.11.135"},{"key":"S2732494X23001481_ref8","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1200\/GO.20.00589","article-title":"Expected medium- and long-term impact of the COVID-19 outbreak in oncology","volume":"7","author":"Onesti","year":"2021","journal-title":"JCO Glob Oncol"},{"key":"S2732494X23001481_ref1","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1007\/s00134-020-06323-9","article-title":"Relationship between SARS-CoV-2 infection and the incidence of ventilator-associated lower respiratory tract infections: a European multicenter cohort study","volume":"47","author":"Rouz\u00e9","year":"2021","journal-title":"Intensive Care Med"},{"key":"S2732494X23001481_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.05.009"},{"key":"S2732494X23001481_ref7","doi-asserted-by":"publisher","DOI":"10.1590\/0037-8682-0090-2021"},{"key":"S2732494X23001481_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2020.07.016"},{"key":"S2732494X23001481_ref17","doi-asserted-by":"publisher","DOI":"10.1093\/trstmh\/trab048"},{"key":"S2732494X23001481_ref24","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myab009"},{"key":"S2732494X23001481_ref16","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27000"},{"key":"S2732494X23001481_ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2021.106619"},{"key":"S2732494X23001481_ref23","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13216"},{"key":"S2732494X23001481_ref2","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1093\/cid\/ciab688","article-title":"The impact of coronavirus disease 2019 (COVID-19) on healthcare-associated infections","volume":"74","author":"Baker","year":"2022","journal-title":"Clin Infect Dis"}],"container-title":["Antimicrobial Stewardship &amp; Healthcare Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S2732494X23001481","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T12:40:54Z","timestamp":1681216854000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S2732494X23001481\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023]]}},"alternative-id":["S2732494X23001481"],"URL":"https:\/\/doi.org\/10.1017\/ash.2023.148","relation":{},"ISSN":["2732-494X"],"issn-type":[{"value":"2732-494X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]},"article-number":"e70"}}