{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T01:20:28Z","timestamp":1750468828799,"version":"3.40.5"},"reference-count":23,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:00:00Z","timestamp":1699401600000},"content-version":"unspecified","delay-in-days":311,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ASHE"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S2732494X23004680_as1\">\n\t    <jats:title>Objective:<\/jats:title>\n\t    <jats:p>Characterize antibiotic prescribing behaviors at an Indian palliative care center after the initiation of the Antibiotic Order Form (AOF): an antibiotic stewardship program involving a paper form to track antibiotic use and to provide prescription guidelines.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X23004680_as2\">\n\t    <jats:title>Design:<\/jats:title>\n\t    <jats:p>Retrospective chart review.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X23004680_as3\">\n\t    <jats:title>Setting:<\/jats:title>\n\t    <jats:p>Trivandrum Institute of Palliative Sciences (TIPS) is a palliative care organization in Kerala, India.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X23004680_as4\">\n\t    <jats:title>Methods:<\/jats:title>\n\t    <jats:p>Antibiotic prescription data and patient data were collected for adult patients treated at TIPS between January 1, 2017, and October 31, 2019. Descriptive statistics and a Zero-Inflated Poisson regression model were used to analyze antibiotic prescriptions. AOF completion and prescription concordance with institutional guidelines were also evaluated.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X23004680_as5\">\n\t    <jats:title>Results:<\/jats:title>\n\t    <jats:p>Out of 7,450 unique patients, 675 (9%) were prescribed 1,448 antibiotics. Age was the strongest factor in determining the number of antibiotic courses with each additional year of age decreasing the expected antibiotic prescription count by 2% per year. The most common antibiotics prescribed were topical metronidazole (44%) and penicillins (29%). Among patients who died, 5% were prescribed antibiotics within the final month of life. In total, 32% of antibiotic prescriptions were documented in AOFs, and 18% were concordant with all institutional antibiotic prescribing guidelines.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X23004680_as6\">\n\t    <jats:title>Conclusions:<\/jats:title>\n\t    <jats:p>This study is the first to analyze an antibiotic stewardship intervention in a palliative care setting within a low- and middle-income country. This retrospective study provides a benchmark of antibiotic use within Indian palliative care and highlights areas for future stewardship research including topical metronidazole use within palliative care and higher rates of antibiotic use among younger palliative care patients.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/ash.2023.468","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T06:10:35Z","timestamp":1699423835000},"source":"Crossref","is-referenced-by-count":2,"title":["Antibiotic stewardship in Indian palliative care: a single-center retrospective study"],"prefix":"10.1017","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1617-7647","authenticated-orcid":false,"given":"David","family":"Thomas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7106-7286","authenticated-orcid":false,"given":"Vijayvardhan","family":"Kamalumpundi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amirtha","family":"Thampi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8017-8084","authenticated-orcid":false,"given":"Kashelle","family":"Lockman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary B.","family":"Carter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Navjyot","family":"Vidwan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Broderick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2023,11,8]]},"reference":[{"key":"S2732494X23004680_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.idh.2018.12.001"},{"key":"S2732494X23004680_ref1","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2013.0276"},{"key":"S2732494X23004680_ref3","doi-asserted-by":"publisher","DOI":"10.1177\/1049909111432625"},{"key":"S2732494X23004680_ref13","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-012576"},{"key":"S2732494X23004680_ref12","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2009.0337"},{"key":"S2732494X23004680_ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2010.00682.x"},{"key":"S2732494X23004680_ref9","doi-asserted-by":"publisher","DOI":"10.1136\/bmjspcare-2015-001008"},{"key":"S2732494X23004680_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2019.05.014"},{"key":"S2732494X23004680_ref22","first-page":"1","article-title":"Antimicrobial use at the end of life: a scoping review","author":"Fairweather","year":"2020","journal-title":"BMJ Support Palliat Care"},{"key":"S2732494X23004680_ref5","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2020.1241"},{"key":"S2732494X23004680_ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s00068-020-01304-5"},{"key":"S2732494X23004680_ref14","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2016.173"},{"key":"S2732494X23004680_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2017.07.009"},{"key":"S2732494X23004680_ref11","doi-asserted-by":"publisher","DOI":"10.2307\/1269547"},{"key":"S2732494X23004680_ref7","doi-asserted-by":"publisher","DOI":"10.1017\/ash.2022.89"},{"key":"S2732494X23004680_ref8","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12803"},{"key":"S2732494X23004680_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4076(86)90002-3"},{"key":"S2732494X23004680_ref17","first-page":"e18431","article-title":"Monitoring antibiotic use in public health care facilities of south Indian union territory: a step to promote rational use of antibiotics","volume":"13","author":"Meena","year":"2021","journal-title":"Cureus"},{"key":"S2732494X23004680_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2012.09.010"},{"volume-title":"Integrating Palliative Care and Symptom Relief into Primary Health Care: A WHO Guide for Planners, Implementers and Managers","year":"2018","key":"S2732494X23004680_ref20"},{"key":"S2732494X23004680_ref15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0205729"},{"key":"S2732494X23004680_ref21","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2016.0701"},{"key":"S2732494X23004680_ref23","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.13080"}],"container-title":["Antimicrobial Stewardship &amp; 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