{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:02:38Z","timestamp":1790240558128,"version":"4.1.0"},"reference-count":13,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"unspecified","delay-in-days":306,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ASHE"],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S2732494X25102003_as1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Invasive candidiasis including candidemia is a common healthcare-associated infections with significant morbidity and mortality. The USA does not have mandatory national surveillance for mucocutaneous or invasive candidiasis which complicates estimation of epidemiology and outcomes. The aim of this project was to describe the epidemiology, mortality, and\n                      <jats:italic>Candida<\/jats:italic>\n                      -associated hospital readmissions in hospitalized patients with\n                      <jats:italic>Candida<\/jats:italic>\n                      species infections.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2732494X25102003_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      This secondary database analysis used clinical microbiology data from adults hospitalized at three large health systems (25-hospitals) in the Greater Houston area totaling over 1.6 million hospitalization days per year from 2018 to 2023. Proportion and rates of Candida cultures per 10,000 hospitalization days were calculated. Risk factors for mortality and\n                      <jats:italic>Candida<\/jats:italic>\n                      -associated readmissions were assessed by multivariable logistic regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2732494X25102003_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Within the study period, 7514 hospitalized patients aged 64 \u00b1 16 years (mean\u00b1 standard deviation (SD)) with 10,183 unique\n                      <jats:italic>Candida<\/jats:italic>\n                      cultures were identified. Majority of\n                      <jats:italic>Candida<\/jats:italic>\n                      cultures were nosocomial (59%) with wide variability in mean time to positive culture (9 \u00b1 44 days) after admission.\n                      <jats:italic>Candida<\/jats:italic>\n                      specimens were from blood (32%), abdomen (29%), or mucocutaneous (24%) cultures and most commonly\n                      <jats:italic>C. albicans<\/jats:italic>\n                      (44%) or\n                      <jats:italic>C. glabrata<\/jats:italic>\n                      (21%).\n                      <jats:italic>C. auris<\/jats:italic>\n                      increased significantly from 2% of cultures from 2018\u201320 to 5% in 2021\u201323 (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.0001). Length of hospital stay was 21 \u00b1 34 days and inpatient mortality was 17%. Multivariable analyses identified hospitalization variables and\n                      <jats:italic>Candida<\/jats:italic>\n                      species predictive of inpatient all-cause mortality and\n                      <jats:italic>Candida<\/jats:italic>\n                      -associated readmissions after initial hospitalization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2732494X25102003_as4\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      These analyses highlight the significant burden of candidiasis and the emergence of new strains, including\n                      <jats:italic>C. auris<\/jats:italic>\n                      . Ongoing surveillance can refine burden estimates and assess the impact of stewardship and infection control interventions.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/ash.2025.10200","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T12:37:46Z","timestamp":1762173466000},"source":"Crossref","is-referenced-by-count":2,"title":["Candidiasis epidemiology and outcomes including emergence of\n                    <i>Candida auris<\/i>\n                    from a large, Southern US metro area: a six-year evaluation"],"prefix":"10.1017","volume":"5","author":[{"given":"Ricky","family":"Huynh-Phan","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/048sx0r50","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Houston College of Pharmacy"},{"name":"Baylor St. Luke\u2019s Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9058-2395","authenticated-orcid":false,"given":"Ardath","family":"Plauche","sequence":"additional","affiliation":[{"name":"Memorial Hermann Health System"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5148-4290","authenticated-orcid":false,"given":"William L.","family":"Musick","sequence":"additional","affiliation":[{"name":"Houston Methodist Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kady","family":"Phe","sequence":"additional","affiliation":[{"name":"Baylor St. Luke\u2019s Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1180-021X","authenticated-orcid":false,"given":"Wesley J.","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Houston Methodist Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayar Al","family":"Mohajer","sequence":"additional","affiliation":[{"name":"Baylor St. Luke\u2019s Medical Center"},{"name":"Baylor College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Lasco","sequence":"additional","affiliation":[{"name":"Baylor St. Luke\u2019s Medical Center"},{"name":"Baylor College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9999-1478","authenticated-orcid":false,"given":"Nicholas D.","family":"Beyda","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/048sx0r50","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Houston College of Pharmacy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6645-406X","authenticated-orcid":false,"given":"Taryn A.","family":"Eubank","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/048sx0r50","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Houston College of Pharmacy"},{"name":"Houston Methodist Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2063-7503","authenticated-orcid":false,"given":"Kevin W.","family":"Garey","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/048sx0r50","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Houston College of Pharmacy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,11,3]]},"reference":[{"key":"S2732494X25102003_ref7","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13236"},{"key":"S2732494X25102003_ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1306801"},{"key":"S2732494X25102003_ref4","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-024-00503-3"},{"key":"S2732494X25102003_ref9","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.ss7404a1"},{"key":"S2732494X25102003_ref2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-023-08050-0"},{"key":"S2732494X25102003_ref8","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ933"},{"key":"S2732494X25102003_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2015.10.023"},{"key":"S2732494X25102003_ref10","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofac559"},{"key":"S2732494X25102003_ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s100960000335"},{"key":"S2732494X25102003_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2025.03.013"},{"key":"S2732494X25102003_ref12","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2024.52"},{"key":"S2732494X25102003_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2019.04.024"},{"key":"S2732494X25102003_ref5","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8010099"}],"container-title":["Antimicrobial Stewardship &amp; Healthcare Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S2732494X25102003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T12:37:47Z","timestamp":1762173467000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S2732494X25102003\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025]]}},"alternative-id":["S2732494X25102003"],"URL":"https:\/\/doi.org\/10.1017\/ash.2025.10200","relation":{},"ISSN":["2732-494X"],"issn-type":[{"value":"2732-494X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"e296"}}