{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:39:24Z","timestamp":1785436764111,"version":"3.56.0"},"reference-count":25,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"unspecified","delay-in-days":330,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ASHE"],"published-print":{"date-parts":[[2025]]},"abstract":"Abstract<\/jats:title>\n \n Objectives:<\/jats:title>\n \n To investigate the epidemiology and clinical outcomes of\n Candida auris<\/jats:italic>\n (\n C. auris<\/jats:italic>\n ), reclassified\n Candidozyma auris<\/jats:italic>\n , in a Detroit tertiary care center, focusing on mortality, length of stay (LOS), glucose variability, and demographic factors.\n <\/jats:p>\n <\/jats:sec>\n \n Setting:<\/jats:title>\n Inpatient admissions in a Detroit tertiary care center, June 2023\u2013March 2025.<\/jats:p>\n <\/jats:sec>\n \n Patients:<\/jats:title>\n \n Among 9,025\n C. auris<\/jats:italic>\n tests, 725 (8.03%) were positive. A subpopulation of 242 hospitalized patients was analyzed for outcomes.\n <\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n Clinical and demographic data, including infection status, mortality, and LOS, were analyzed. Glucose variability was assessed by the coefficient of variation. ANOVA and Kruskal\u2013Wallis tests evaluated group differences, pairwise Z-tests compared mortality, and a competing-risks survival analysis estimated probabilities of discharge and in-hospital death.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Mortality was highest among colonized\/infected patients (31.3%) and significantly associated with race (\n p<\/jats:italic>\n = 0.0072) and ethnicity (\n p<\/jats:italic>\n = 0.0069). High glucose variability (>190 mg\/dL) was linked to increased mortality (27.63%) and prolonged LOS (46.14 days;\n p<\/jats:italic>\n < 0.01). Infected patients had the longest LOS (67.9 days), followed by colonized\/infected (39.9) and colonized-only (30.2;\n p<\/jats:italic>\n < 0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n C. auris<\/jats:italic>\n disproportionately affects African American patients and those with high glucose variability, contributing to higher mortality and longer hospitalization. Infection status and glycemic instability were the strongest predictors of LOS, while racial and ethnic disparities influenced mortality. Strengthened infection control, early identification, and optimized glucose management may improve outcomes in high-risk populations.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1017\/ash.2025.10237","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T03:39:31Z","timestamp":1764214771000},"source":"Crossref","is-referenced-by-count":0,"title":["Epidemiology, length of stay, and survival outcomes of\n Candida auris<\/i>\n infections in a tertiary care center in the greater detroit area"],"prefix":"10.1017","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6645-6738","authenticated-orcid":false,"given":"Hussein","family":"Tehaili","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01070mq45","id-type":"ROR","asserted-by":"publisher"}],"name":"Wayne State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0032-5242","authenticated-orcid":false,"given":"Shayan","family":"Sharifi","sequence":"additional","affiliation":[{"name":"Wayne State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sruti","family":"Ramamoorthy","sequence":"additional","affiliation":[{"name":"Wayne State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melike","family":"Yildirim","sequence":"additional","affiliation":[{"name":"Wayne State University"},{"name":"Wayne State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabhnoor","family":"Dhillon","sequence":"additional","affiliation":[{"name":"Wayne State University"},{"name":"Detroit Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raveen","family":"Mahngar","sequence":"additional","affiliation":[{"name":"Detroit Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavina","family":"Jabbo","sequence":"additional","affiliation":[{"name":"Detroit Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5242-3847","authenticated-orcid":false,"given":"Marco R.","family":"Scipione","sequence":"additional","affiliation":[{"name":"Detroit Receiving Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Salimnia","sequence":"additional","affiliation":[{"name":"Detroit Medical Center"},{"name":"Wayne State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2221-008X","authenticated-orcid":false,"given":"Glenn","family":"Tillotson","sequence":"additional","affiliation":[{"name":"GST Micro North"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1185-4549","authenticated-orcid":false,"given":"Teena","family":"Chopra","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01070mq45","id-type":"ROR","asserted-by":"publisher"}],"name":"Wayne State University"},{"name":"Detroit Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,11,27]]},"reference":[{"key":"S2732494X25102374_ref18","doi-asserted-by":"publisher","DOI":"10.1081\/BIP-200062284"},{"key":"S2732494X25102374_ref17","first-page":"1","article-title":"Kruskal-Wallis test","volume":"1","author":"McKight","year":"2010","journal-title":"Corsini Encycl Psychol"},{"key":"S2732494X25102374_ref20","first-page":"715","article-title":"\u201cClinical outcomes of patients with Candida auris infection and colonization in Colombia\u201d","volume":"9","author":"Escand\u00f3n","year":"2023","journal-title":"J Fungi"},{"key":"S2732494X25102374_ref23","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2023.74"},{"key":"S2732494X25102374_ref7","unstructured":"7. Michigan Department of Health and Human Services. Candida Auris surveillance report - August 26. 2024. https:\/\/www.michigan.gov\/mdhhs\/-\/media\/Project\/Websites\/mdhhs\/HAI-SHARP\/MDROs\/Cauris-Survei. Accessed January 27, 2025."},{"key":"S2732494X25102374_ref12","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-1769"},{"key":"S2732494X25102374_ref25","unstructured":"25. Centers for Disease Control and Prevention. Antibiotic Resistance Threats in the United States, US Department of Health and Human Services, 2019. 2019. https:\/\/www.cdc.gov\/drugresistance\/pdf\/threats-report\/2019-ar-threats-report-508.pdf. Accessed February 2025."},{"key":"S2732494X25102374_ref2","first-page":"e00029","article-title":"Candida auris: a review of the literature","volume":"31","author":"Jeffery-Smith","year":"2017","journal-title":"Clin Microbiol Rev"},{"key":"S2732494X25102374_ref4","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6619a7"},{"key":"S2732494X25102374_ref1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw691"},{"key":"S2732494X25102374_ref8","doi-asserted-by":"publisher","DOI":"10.1017\/ash.2024.234"},{"key":"S2732494X25102374_ref10","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa193"},{"key":"S2732494X25102374_ref9","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofad500.1291"},{"key":"S2732494X25102374_ref14","first-page":"21","article-title":"Power comparisons of Shapiro-Wilk, Kolmogorov-Smirnov, Lilliefors and Anderson-Darling tests","volume":"2","author":"Razali","year":"2011","journal-title":"J Stat Model Anal"},{"key":"S2732494X25102374_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2018.08.028"},{"key":"S2732494X25102374_ref5","doi-asserted-by":"publisher","DOI":"10.3201\/eid2907.230540"},{"key":"S2732494X25102374_ref11","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-2430"},{"key":"S2732494X25102374_ref3","doi-asserted-by":"publisher","DOI":"10.7326\/M22-3469"},{"key":"S2732494X25102374_ref15","doi-asserted-by":"publisher","DOI":"10.2307\/2413207"},{"key":"S2732494X25102374_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.csda.2003.10.021"},{"key":"S2732494X25102374_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.gloepi.2022.100080"},{"key":"S2732494X25102374_ref21","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2402635"},{"key":"S2732494X25102374_ref22","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy277"},{"key":"S2732494X25102374_ref24","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw808"},{"key":"S2732494X25102374_ref6","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofad500.2092"}],"container-title":["Antimicrobial Stewardship & Healthcare Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S2732494X25102374","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T03:39:32Z","timestamp":1764214772000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S2732494X25102374\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025]]}},"alternative-id":["S2732494X25102374"],"URL":"https:\/\/doi.org\/10.1017\/ash.2025.10237","relation":{},"ISSN":["2732-494X"],"issn-type":[{"value":"2732-494X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"e321"}}