{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T08:05:04Z","timestamp":1764576304515,"version":"3.46.0"},"reference-count":26,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"unspecified","delay-in-days":334,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ASHE"],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S2732494X25102404_as1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Evaluating the COVID-19 pandemic restrictions and their effect on rates of new respiratory viral infections in patients undergoing hematopoietic stem cell transplantation (HSCT), and if there were changes to the morbidity and mortality rates compared to historical controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2732494X25102404_as2\">\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Retrospective chart review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2732494X25102404_as3\">\n                    <jats:title>Setting:<\/jats:title>\n                    <jats:p>University-based tertiary care center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2732494X25102404_as4\">\n                    <jats:title>Patients:<\/jats:title>\n                    <jats:p>All patients who underwent HSCT, including chimeric antigen receptor T-cell therapy, between 7\/1\/2013 and 12\/19\/2021 were included in the study. No eligible patients were excluded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2732494X25102404_as5\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We found a significant difference in new respiratory infections as measured by a respiratory viral pathogen (RVP) polymerase chain reaction-based assay during transplant admissions between the pre- and early COVID-19 eras, with complete absence of new respiratory viral infections in the early COVID-19 era. The late-COVID-19 era, coincident with availability of severe acute respiratory syndrome coronavirus 2\u00a0vaccines and relaxation of some hospital-based restrictions, had a similar incidence of new RVP positivity compared to the pre-COVID-19 era. For allogeneic HSCT outcomes alone, rates of pediatric intensive care unit admission (66.7% vs 32.2%,\n                      <jats:italic>p<\/jats:italic>\n                      = .01), intubation (57.1% and 18.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt; .01), and oxygen requirement (66.7% vs 40.7%,\n                      <jats:italic>p<\/jats:italic>\n                      = .04) were found to be statistically different with new RVP positivity. Other outcomes examined, including death at 100\/180\/365 days post-transplant, length of stay, and acute graft-versus-host disease incidence, were similar, regardless of new RVP positivity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2732494X25102404_as6\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In order to reduce morbidity, these findings argue for a continuation of the strict protective isolation practices initially employed during the pandemic for HSCT patients, particularly during viral emergence following the COVID-19 lockdown.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/ash.2025.10240","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T08:00:32Z","timestamp":1764576032000},"source":"Crossref","is-referenced-by-count":0,"title":["Hospital-mandated restrictions during the COVID-19 pandemic alter hospital-acquired viral respiratory infections during hematopoietic stem cell transplantation: a single center pediatric experience"],"prefix":"10.1017","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0479-1607","authenticated-orcid":false,"given":"Perry","family":"Morocco","sequence":"first","affiliation":[{"name":"University of Chicago"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0866-8681","authenticated-orcid":false,"given":"Madan","family":"Kumar","sequence":"additional","affiliation":[{"name":"University of Chicago"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5212-0129","authenticated-orcid":false,"given":"Miranda","family":"Foote","sequence":"additional","affiliation":[{"name":"University of Chicago"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caitlin","family":"Cohen","sequence":"additional","affiliation":[{"name":"University of Chicago"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Nassin","sequence":"additional","affiliation":[{"name":"University of Chicago"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Cunningham","sequence":"additional","affiliation":[{"name":"University of Chicago"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6776-4695","authenticated-orcid":false,"given":"James","family":"LaBelle","sequence":"additional","affiliation":[{"name":"University of Chicago"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2025,12,1]]},"reference":[{"key":"S2732494X25102404_ref8","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-021-01319-5"},{"key":"S2732494X25102404_ref19","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.215152"},{"key":"S2732494X25102404_ref17","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/pix051"},{"key":"S2732494X25102404_ref5","unstructured":"5. 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The impact of COVID-19 outbreak on nosocomial infection rate: a case of Iran, Can J Infect Dis Med Microbiol 2021;6650920:1\u20136.","DOI":"10.1155\/2021\/6650920"},{"key":"S2732494X25102404_ref11","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw451"},{"key":"S2732494X25102404_ref15","doi-asserted-by":"publisher","DOI":"10.1111\/tid.70101"},{"key":"S2732494X25102404_ref2","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2020.588203"},{"key":"S2732494X25102404_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2020.07.027"}],"container-title":["Antimicrobial Stewardship &amp; Healthcare Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S2732494X25102404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T08:00:36Z","timestamp":1764576036000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S2732494X25102404\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025]]}},"alternative-id":["S2732494X25102404"],"URL":"https:\/\/doi.org\/10.1017\/ash.2025.10240","relation":{},"ISSN":["2732-494X"],"issn-type":[{"value":"2732-494X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"e327"}}