{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:14:13Z","timestamp":1785402853443,"version":"3.56.0"},"reference-count":24,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"unspecified","delay-in-days":352,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ASHE"],"published-print":{"date-parts":[[2025]]},"abstract":"Abstract<\/jats:title>\n \n Background:<\/jats:title>\n \n Outbreaks of vancomycin-resistant\n Enterococcus faecium<\/jats:italic>\n (VRE) are often difficult to contain. In this study, we developed and implemented a set of control measures, which resulted in a relatively limited outbreak in a secondary care hospital in Sweden.\n <\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n VRE screening was performed by rapid polymerase chain reaction (PCR) on fecal swabs, reported within 1\u20133 h. Vancomycin-resistant isolates PCR-positive for the\n vanA<\/jats:italic>\n \/\n vanB<\/jats:italic>\n gene were further analyzed with whole-genome sequencing (WGS). Cleaning efficiency was evaluated directly after cleaning by using adenosine triphosphate (ATP) swabs, detecting organic live material. The hospital management appointed a task force consisting of experts in infectious diseases, microbiology, hospital hygiene, cleaning and representatives of the affected unit.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n A total of 22 VRE-positive patients were identified, of which 12 isolates belonged to the same clone (ST 203) in a surgical ward. VRE screening by PCR shortened the turnaround time. The combination of rapid PCR and WGS could rule in or out cases from the outbreak within less than a week. The new cleaning routine indicated that 3 approved quality-controlled discharge cleanings were required to reduce VRE acquisition. The fast lane to decision-making on control measures resulted in rapid introduction of the above routines.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n With prompt infection control measures, the VRE outbreak was contained after 4 months. To prevent further outbreaks of VRE, active rapid screening, improved cleaning, and restriction of multiple-bed rooms are efficient measures to implement.<\/jats:p>\n <\/jats:sec>","DOI":"10.1017\/ash.2025.10251","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T07:33:53Z","timestamp":1766129633000},"source":"Crossref","is-referenced-by-count":0,"title":["A successfully shortened outbreak of vancomycin-resistant\n Enterococcus faecium<\/i>\n in a secondary care hospital in Sweden"],"prefix":"10.1017","volume":"5","author":[{"given":"Maria","family":"Gideskog","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05ynxx418","id-type":"ROR","asserted-by":"publisher"}],"name":"Link\u00f6ping University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6704-951X","authenticated-orcid":false,"given":"Jenny","family":"Welander","sequence":"additional","affiliation":[{"name":"Link\u00f6ping University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0854-7508","authenticated-orcid":false,"given":"Anita","family":"H\u00e4llgren","sequence":"additional","affiliation":[{"name":"Link\u00f6ping University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9058-3582","authenticated-orcid":false,"given":"Lena","family":"Serrander","sequence":"additional","affiliation":[{"name":"Link\u00f6ping University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"S2732494X25102519_ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-019-0680-y"},{"key":"S2732494X25102519_ref9","doi-asserted-by":"publisher","DOI":"10.2807\/ese.15.29.19620-en"},{"key":"S2732494X25102519_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2016.07.009"},{"key":"S2732494X25102519_ref10","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.14826.1"},{"key":"S2732494X25102519_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2021.11.020"},{"key":"S2732494X25102519_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2017.04.290"},{"key":"S2732494X25102519_ref2","volume-title":"Vancomycin-Resistant Enterococci","author":"Levitus","year":"2021"},{"key":"S2732494X25102519_ref22","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200012283432604"},{"key":"S2732494X25102519_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmni.2016.12.020"},{"key":"S2732494X25102519_ref7","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-018-3388-y"},{"key":"S2732494X25102519_ref18","first-page":"Doc07","article-title":"Can the adenosine triphosphate (ATP) bioluminescence assay be used as an indicator for hospital cleaning? - a pilot study","volume":"19","author":"Niephaus","year":"2024","journal-title":"GMS Hyg Infect Control"},{"key":"S2732494X25102519_ref11","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.6.1963-1971.2002"},{"key":"S2732494X25102519_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2018.12.015"},{"key":"S2732494X25102519_ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s10482-011-9681-z"},{"key":"S2732494X25102519_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.idh.2021.05.003"},{"key":"S2732494X25102519_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2018.02.003"},{"key":"S2732494X25102519_ref19","doi-asserted-by":"publisher","DOI":"10.1086\/588566"},{"key":"S2732494X25102519_ref6","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofab056"},{"key":"S2732494X25102519_ref14","doi-asserted-by":"publisher","DOI":"10.1086\/659403"},{"key":"S2732494X25102519_ref4","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00211-16"},{"key":"S2732494X25102519_ref23","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz900"},{"key":"S2732494X25102519_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2017.12.016"},{"key":"S2732494X25102519_ref16","first-page":"261","article-title":"Disinfection of hospital rooms contaminated with vancomycin-resistant enterococcus faecium","volume":"19","author":"Byers","year":"1998","journal-title":"Infect Control Hosp Epidemiol"},{"key":"S2732494X25102519_ref3","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.GPP3-0053-2018"}],"container-title":["Antimicrobial Stewardship & Healthcare Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S2732494X25102519","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T07:33:54Z","timestamp":1766129634000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S2732494X25102519\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025]]}},"alternative-id":["S2732494X25102519"],"URL":"https:\/\/doi.org\/10.1017\/ash.2025.10251","relation":{},"ISSN":["2732-494X"],"issn-type":[{"value":"2732-494X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"e346"}}