{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T10:50:15Z","timestamp":1771066215915,"version":"3.50.1"},"reference-count":38,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T00:00:00Z","timestamp":1739318400000},"content-version":"unspecified","delay-in-days":42,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ASHE"],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S2732494X25000129_as1\">\n\t    <jats:title>Objective:<\/jats:title>\n\t    <jats:p>Develop a <jats:italic>Staphylococcus aureus<\/jats:italic> wound antibiogram among patients who use fentanyl (PWUF) presenting with acute <jats:italic>S. aureus<\/jats:italic> skin and soft tissue infections (SSTIs) in Philadelphia, Pennsylvania.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X25000129_as2\">\n\t    <jats:title>Design:<\/jats:title>\n\t    <jats:p>Retrospective, multisite cohort study.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X25000129_as3\">\n\t    <jats:title>Patients and Setting:<\/jats:title>\n\t    <jats:p>Individuals presenting to emergency departments or admitted to inpatient units of four Penn Medicine hospitals with an acute <jats:italic>S. aureus<\/jats:italic> SSTI and illicit fentanyl use within the previous year.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X25000129_as4\">\n\t    <jats:title>Methods:<\/jats:title>\n\t    <jats:p>We described susceptibilities of <jats:italic>S. aureus<\/jats:italic> isolated from wound cultures among the PWUF cohort and compared these to the health system\u2019s wound antibiogram. We compared frequency of in-hospital medication treatment for opioid use disorder among patients who left the hospital prior to vs after the availability of <jats:italic>S. aureus<\/jats:italic> susceptibilities.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X25000129_as5\">\n\t    <jats:title>Results:<\/jats:title>\n\t    <jats:p>Among 131 <jats:italic>S. aureus<\/jats:italic> isolates from 131 PWUF, 35\/131 (26.7%) were susceptible to oxacillin, 73\/121 (60.3%) were susceptible to clindamycin, 77\/122 (63.1%) were susceptible to tetracycline, and 119\/126 (94.4%) were susceptible to trimethoprim-sulfamethoxazole. PWUF displayed significantly reduced susceptibility to oxacillin and tetracycline compared to the health system\u2019s outpatient wound <jats:italic>S. aureus<\/jats:italic> antibiogram. Compared to patients discharged prior to susceptibility availability, more patients discharged after the reporting of susceptibilities were administered buprenorphine or methadone in the hospital (82.0% vs 51.4%, <jats:italic>P<\/jats:italic> &lt; 0.001).<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X25000129_as6\">\n\t    <jats:title>Conclusion:<\/jats:title>\n\t    <jats:p>High nonsusceptibility to clindamycin and tetracycline suggests these agents should not be prescribed as empiric therapy for acute <jats:italic>S. aureus<\/jats:italic> SSTI in PWUF in Philadelphia. PWUF would benefit from joint management by infectious diseases and addiction medicine experts to ensure prescription of active therapy. Additional study is needed of PWUF in other regions.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/ash.2025.12","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T07:08:58Z","timestamp":1739344138000},"source":"Crossref","is-referenced-by-count":2,"title":["<i>Staphylococcus aureus<\/i> susceptibilities from wounds of patients who use illicit fentanyl"],"prefix":"10.1017","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8018-4070","authenticated-orcid":false,"given":"Drew T.","family":"Dickinson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Saw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Dutcher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5590-2736","authenticated-orcid":false,"given":"Christina","family":"Maguire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8647-786X","authenticated-orcid":false,"given":"Adrienne","family":"Terico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5450-6814","authenticated-orcid":false,"given":"Margaret","family":"Lowenstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonal","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2025,2,12]]},"reference":[{"key":"S2732494X25000129_ref1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268810000464"},{"key":"S2732494X25000129_ref20","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.17199"},{"key":"S2732494X25000129_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"S2732494X25000129_ref38","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2021.103255"},{"key":"S2732494X25000129_ref32","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofab633"},{"key":"S2732494X25000129_ref12","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac714"},{"key":"S2732494X25000129_ref15","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.882421"},{"key":"S2732494X25000129_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"S2732494X25000129_ref2","doi-asserted-by":"publisher","DOI":"10.1111\/acem.12727"},{"key":"S2732494X25000129_ref27","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofae261"},{"key":"S2732494X25000129_ref5","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6826a2"},{"key":"S2732494X25000129_ref28","doi-asserted-by":"publisher","DOI":"10.1086\/342196"},{"key":"S2732494X25000129_ref22","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir308"},{"key":"S2732494X25000129_ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-004-3106-0"},{"key":"S2732494X25000129_ref33","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMicm2303601"},{"key":"S2732494X25000129_ref29","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268814003227"},{"key":"S2732494X25000129_ref16","doi-asserted-by":"publisher","DOI":"10.1136\/injuryprev-2020-043968"},{"key":"S2732494X25000129_ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2021.108465"},{"key":"S2732494X25000129_ref11","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.21288"},{"key":"S2732494X25000129_ref13","unstructured":"13. 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