{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T21:49:26Z","timestamp":1793224166282,"version":"4.5.0"},"reference-count":29,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"unspecified","delay-in-days":110,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ASHE"],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S2732494X25000622_as1\">\n\t    <jats:title>Background:<\/jats:title>\n\t    <jats:p>Optimizing antibiotic prescribing for urinary tract infections (UTI) represents an opportunity for ambulatory antibiotic stewardship programs (ASPs). A pre-populated order panel for UTI was implemented in the Mayo Clinic Enterprise in May 2022. The order panel provides antibiotic regimens aligning with institutional guidelines according to patient characteristics, presence or absence of complicating features, and antimicrobial allergy status. We assessed impacts of panel use on prescribing practices for cystitis.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X25000622_as2\">\n\t    <jats:title>Methods:<\/jats:title>\n\t    <jats:p>This retrospective cohort study of ambulatory encounters with a primary diagnosis of cystitis from May 16, 2022, to May 15, 2023, compared encounters in which the order panel was utilized to encounters managed without the panel. The primary outcome was concordance with institutional guidelines, including drug selection, dose\/frequency, and duration. Secondary outcomes included rate of repeat healthcare contact for UTI within 14 days and total duration of therapy.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X25000622_as3\">\n\t    <jats:title>Results:<\/jats:title>\n\t    <jats:p>793 randomly selected patient encounters (397 panel and 396 non-panel) were included. Prescribing was guideline adherent in 79.3% and 64.9% (<jats:italic>P<\/jats:italic> &lt; 0.001) of panel and non-panel encounters, respectively. There were more 3- and 5-day treatment courses in the panel cohort; however, inappropriate duration of therapy was the most common reason for non-concordance in both cohorts. There was no significant difference between groups in repeat 14-day healthcare contact for UTI (13.4% panel vs 11.1% no panel, <jats:italic>P<\/jats:italic> = 0.34).<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2732494X25000622_as4\">\n\t    <jats:title>Conclusion:<\/jats:title>\n\t    <jats:p>Use of a pre-populated ambulatory order panel for the treatment of cystitis was associated with greater concordance with institutional guidelines, without adversely impacting repeat healthcare contact for UTI.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/ash.2025.62","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T12:22:16Z","timestamp":1745238136000},"source":"Crossref","is-referenced-by-count":3,"title":["Impact of an evidence-based order panel on antibiotic prescribing in ambulatory patients with cystitis"],"prefix":"10.1017","volume":"5","author":[{"given":"Matt","family":"Neumann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan W.","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8783-0191","authenticated-orcid":false,"given":"Kristin","family":"Cole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6581-3956","authenticated-orcid":false,"given":"Paschalis","family":"Vergidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3437-7159","authenticated-orcid":false,"given":"Abinash","family":"Virk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0778-3901","authenticated-orcid":false,"given":"Dan","family":"Ilges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8372-3316","authenticated-orcid":false,"given":"Kelsey L.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,4,21]]},"reference":[{"key":"S2732494X25000622_ref5","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz910"},{"key":"S2732494X25000622_ref15","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofad585"},{"key":"S2732494X25000622_ref1","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1001\/jama.2016.4151","article-title":"Prevalence of inappropriate antibiotic prescriptions among US ambulatory care visits, 2010\u20132011","volume":"315","author":"Fleming-Dutra","year":"2016","journal-title":"JAMA"},{"key":"S2732494X25000622_ref17","doi-asserted-by":"publisher","DOI":"10.1002\/jac5.1578"},{"key":"S2732494X25000622_ref14","doi-asserted-by":"publisher","DOI":"10.1186\/s12875-014-0194-5"},{"key":"S2732494X25000622_ref28","unstructured":"28. European Association of Urology. EAU Guidelines. Presented at the EAU Annual Congress Paris 2024. ISBN 978-94-92671-23-3."},{"key":"S2732494X25000622_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2015.12.002"},{"key":"S2732494X25000622_ref18","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku191"},{"key":"S2732494X25000622_ref6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.idc.2013.09.003","article-title":"Urinary tract infection syndromes: occurrence, recurrence, bacteriology, risk factors, and disease burden","volume":"28","author":"Foxman","year":"2014","journal-title":"Infect Dis Clin North Am"},{"key":"S2732494X25000622_ref27","doi-asserted-by":"crossref","first-page":"e103","DOI":"10.1093\/cid\/ciq257","article-title":"International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: a 2010 update by the infectious diseases society of America and the European society for microbiology and infectious diseases","volume":"52","author":"Gupta","year":"2011","journal-title":"Clin Infect Dis"},{"key":"S2732494X25000622_ref20","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.167.20.2207"},{"key":"S2732494X25000622_ref4","unstructured":"4. The Joint Commission. R3 report, issue 23: antimicrobial stewardship in ambulatory health care. Published 2019. Accessed November 25, 2024. https:\/\/www.jointcommission.org\/standards\/r3-report\/r3-report-issue-23-antimicrobial-stewardship-in-ambulatory-health-care"},{"key":"S2732494X25000622_ref12","doi-asserted-by":"crossref","first-page":"e0000320","DOI":"10.1128\/CMR.00003-20","article-title":"The five Ds of outpatient antibiotic stewardship for urinary tract infections","volume":"34","author":"Goebel","year":"2021","journal-title":"Clin Microbiol Rev"},{"key":"S2732494X25000622_ref7","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq257"},{"key":"S2732494X25000622_ref13","first-page":"276","article-title":"The inconvincible patient: How clinicians perceive demand for antibiotics in the outpatient setting","volume":"37","author":"Kohut","year":"2020","journal-title":"Fam Pract"},{"key":"S2732494X25000622_ref2","unstructured":"2. Centers for Disease Control and Prevention. Outpatient antibiotic prescriptions \u2014 United States, 2022. Published 2022. Accessed November 25, 2024. https:\/\/www.cdc.gov"},{"key":"S2732494X25000622_ref9","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofv159"},{"key":"S2732494X25000622_ref29","first-page":"181","article-title":"Current trends in antimicrobial resistance of Escherichia coli","volume":"416","author":"Paitan","year":"2018","journal-title":"Curr Top Microbiol Immunol"},{"key":"S2732494X25000622_ref22","first-page":"469","article-title":"Optimal duration of antibiotic therapy for uncomplicated urinary tract infection in older women: a double-blind randomized controlled trial","volume":"170","author":"Vogel","year":"2004","journal-title":"CMAJ"},{"key":"S2732494X25000622_ref26","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy1121"},{"key":"S2732494X25000622_ref11","doi-asserted-by":"crossref","first-page":"e00337","DOI":"10.1128\/AAC.00337-18","article-title":"Prevalence of inappropriate antibiotic prescribing in primary care clinics within a veterans affairs health care system","volume":"62","author":"Shively","year":"2018","journal-title":"Antimicrob Agents Chemother"},{"key":"S2732494X25000622_ref19","doi-asserted-by":"publisher","DOI":"10.1002\/jac5.1528"},{"key":"S2732494X25000622_ref10","doi-asserted-by":"crossref","first-page":"ofw159","DOI":"10.1093\/ofid\/ofw159","article-title":"Outpatient antibiotic prescribing practices for uncomplicated urinary tract infection in women in the United States, 2002-2011","volume":"3","author":"Kobayashi","year":"2016","journal-title":"Open Forum Infect Dis"},{"key":"S2732494X25000622_ref25","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.4036"},{"key":"S2732494X25000622_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.02.005"},{"key":"S2732494X25000622_ref8","doi-asserted-by":"publisher","DOI":"10.1111\/apm.12718"},{"key":"S2732494X25000622_ref24","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofu019"},{"key":"S2732494X25000622_ref16","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.japh.2019.03.006","article-title":"Development and implementation of a clinical decision support tool for treatment of uncomplicated urinary tract infections in a family medicine resident clinic","volume":"59","author":"Eudaley","year":"2019","journal-title":"J Am Pharm Assoc"},{"key":"S2732494X25000622_ref21","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh414"}],"container-title":["Antimicrobial Stewardship &amp; Healthcare Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S2732494X25000622","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T12:22:20Z","timestamp":1745238140000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S2732494X25000622\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025]]}},"alternative-id":["S2732494X25000622"],"URL":"https:\/\/doi.org\/10.1017\/ash.2025.62","relation":{},"ISSN":["2732-494X"],"issn-type":[{"value":"2732-494X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"e96"}}