{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:41:12Z","timestamp":1785404472113,"version":"3.56.0"},"reference-count":21,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"unspecified","delay-in-days":85,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ASHE"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S2732494X26103301_as1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Antibiotic stewardship programs (ASPs) aim to optimize antibiotic prescribing, as prolonged use increases the risk of adverse events, antimicrobial resistance, and unnecessary healthcare costs. This study aimed to determine the period prevalence of prolonged antibiotic treatment durations for community-onset infections in Dutch hospitals and to identify risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2732494X26103301_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective cohort study was conducted among adults treated for urinary tract infections (UTI), respiratory tract infections (RTI), or skin and soft tissue infections (SSTI) in four Dutch secondary care hospitals from January 1, 2021, to December 31, 2023. Patients were included if they were admitted for \u226512 hours and treated with antibiotics within 48 hours. Antibiotic prescriptions were linked to infectious diagnoses to calculate length of therapy and compared against national guidelines to assess prolonged treatment. Backward stepwise multivariable logistic regression was used to identify risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2732494X26103301_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of 9,878 admissions, 39.6% had UTIs, 44.9% RTIs, and 15.4% SSTIs. Prolonged antibiotic use was observed in 30%, with the highest proportion in RTIs (49.6%). Among RTIs, prolonged use occurred in 51.0% of community-acquired pneumonia (CAP) and 55.9% of aspiration pneumonia, with a combined median excess duration of 1.6 days (IQR: 0.9\u20133.6)). Prolonged use was 14.3% in UTIs and 13.1% in SSTIs. Risk factors included positive cultures, intravenous-to-oral switch, aspiration pneumonia or CAP (RTIs), and cystitis (UTIs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2732494X26103301_as4\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>A high period prevalence of patients with RTIs receiving prolonged antibiotic treatment was observed. The identified risk factors should be considered in ASPs to improve prescribing and reduce non-guideline-concordant antibiotic therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/ash.2026.10330","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T11:38:53Z","timestamp":1774611533000},"source":"Crossref","is-referenced-by-count":0,"title":["Prolonged antibiotic treatment durations for community-onset infections in Dutch hospitals"],"prefix":"10.1017","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6839-9761","authenticated-orcid":false,"given":"Sharon E.J.D.","family":"van den Eijnde","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0575yy874","id-type":"ROR","asserted-by":"publisher"}],"name":"University Medical Centre Utrecht"},{"id":[{"id":"https:\/\/ror.org\/045nawc23","id-type":"ROR","asserted-by":"publisher"}],"name":"Tergooi Medical Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1334-2232","authenticated-orcid":false,"given":"Jesper","family":"van Breeschoten","sequence":"additional","affiliation":[{"name":"Haga Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5115-3275","authenticated-orcid":false,"given":"Jurjen S.","family":"Kingma","sequence":"additional","affiliation":[{"name":"Hospital Group Twente"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6148-7397","authenticated-orcid":false,"given":"Emile M.","family":"Kuck","sequence":"additional","affiliation":[{"name":"Diakonessenhuis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D.","family":"van der Linden","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0575yy874","id-type":"ROR","asserted-by":"publisher"}],"name":"University Medical Centre Utrecht"},{"id":[{"id":"https:\/\/ror.org\/045nawc23","id-type":"ROR","asserted-by":"publisher"}],"name":"Tergooi Medical Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0626-4635","authenticated-orcid":false,"given":"Cornelis H.","family":"van Werkhoven","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0575yy874","id-type":"ROR","asserted-by":"publisher"}],"name":"University Medical Centre Utrecht"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"key":"S2732494X26103301_ref3","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2017.1938"},{"key":"S2732494X26103301_ref10","unstructured":"10. Klinkhamer, S , Geerlings, SE , Knottnerus, BJ , et\u00a0al. Urineweginfecties, 2025. https:\/\/richtlijnen.nhg.org\/. Accessed July 1, 2025."},{"key":"S2732494X26103301_ref8","unstructured":"8. Schuts, EC , Hulscher, MEJL , Mouton, JW , et\u00a0al. SWAB guidelines for antimicrobial stewardship, 2016. https:\/\/swab.nl\/nl\/richtlijnen-swab. Accessed July 1, 2025."},{"key":"S2732494X26103301_ref13","unstructured":"13. NVDV. Cellulitis-erysipelas onderste extremiteiten, 2013. richtlijnendatabase.nl. Accessed July 1, 2025."},{"key":"S2732494X26103301_ref5","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2016.276"},{"key":"S2732494X26103301_ref15","unstructured":"15. NVALT. Aandoeningen van de pleura, 2019. richtlijnendatabase.nl. Accessed July 14, 2025."},{"key":"S2732494X26103301_ref17","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14215426"},{"key":"S2732494X26103301_ref11","unstructured":"11. van Daalen, FV , Boersma, WG , van de Garde, EMW , et\u00a0al. 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Bacteri\u00eble huidinfecties, 2024. https:\/\/richtlijnen.nhg.org\/. Accessed July 1, 2025."},{"key":"S2732494X26103301_ref9","unstructured":"9. Terpstra, ML , Geerlings, SE , van Nieuwkoop, C , et\u00a0al. Optimization of the antibiotic policy in the Netherlands: SWAB guidelines for antimicrobial therapy of urinary tract infections in adults, 2020. https:\/\/swab.nl\/nl\/richtlijnen-swab. Accessed July 1, 2025."}],"container-title":["Antimicrobial Stewardship &amp; Healthcare Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S2732494X26103301","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T11:38:57Z","timestamp":1774611537000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S2732494X26103301\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026]]}},"alternative-id":["S2732494X26103301"],"URL":"https:\/\/doi.org\/10.1017\/ash.2026.10330","relation":{},"ISSN":["2732-494X"],"issn-type":[{"value":"2732-494X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"e70"}}