{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:41:40Z","timestamp":1785408100522,"version":"3.56.0"},"reference-count":32,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"unspecified","delay-in-days":105,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ASHE"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S2732494X26103544_as1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate the incidence, risk factors, and outcomes associated with multidrug-resistant organisms (MDROs) colonization in patients undergoing elective orthopedic surgery at the Thammasat University Hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2732494X26103544_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      We conducted a prospective MDROs surveillance screening (swabs from the nose, throat, groin, and rectum) in patients undergoing orthopedic surgery. MDROs were defined as extended-spectrum \u03b2-lactamase (ESBL)-producing Gram-negative bacteria (GNB), carbapenem-resistant\n                      <jats:italic>Enterobacterales<\/jats:italic>\n                      , methicillin-resistant\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                      , and vancomycin-resistant enterococci. The incidence of MDROs colonization, risk factors, and outcomes including surgical site infections (SSIs) were assessed. Postoperative SSIs were compared between patients with and without MDROs colonization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2732494X26103544_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of 384 swabs tested from 96 patients, ESBL-producing\n                      <jats:italic>Escherichia coli<\/jats:italic>\n                      was identified in 38 isolates (31 rectal swabs and 7 groin swabs) from 31 patients (32.3%). Only one patient had a history of admission within the previous year. Majority of procedures involved prosthetic implantation (77.1%) including total knee arthroplasty (30.2%). Seven patients (7.3%) developed SSIs without microbiological confirmation. The incidence of SSIs was higher among patients with ESBL-producing\n                      <jats:italic>E. coli<\/jats:italic>\n                      colonization compared to patients without colonization (6\/31, 19.4% vs. 1\/65, 1.5%;\n                      <jats:italic>P<\/jats:italic>\n                      = .004; odds ratio, 15.36; 95% CI 1.7\u2013356.3). From the multivariate logistic regression analysis, preoperative ESBL-producing\n                      <jats:italic>E. coli<\/jats:italic>\n                      colonization was associated with SSIs (\n                      <jats:italic>P<\/jats:italic>\n                      = .014, adjusted odds ratio 16.53, 95% CI 1.78\u2013153.44).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2732494X26103544_as4\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Preoperative ESBL-producing\n                      <jats:italic>E. coli<\/jats:italic>\n                      colonization was common among patients undergoing orthopedic surgery and possibly increased risk of SSIs. Further studies for multidrug-resistant GNB screening, surgical outcomes, and antibiotic prophylaxis modification should be considered in endemic regions.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/ash.2026.10354","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T06:37:34Z","timestamp":1776321454000},"source":"Crossref","is-referenced-by-count":0,"title":["Incidence and outcomes for colonization of multidrug-resistance organisms (MDROs) among patients undergoing elective orthopedic surgery"],"prefix":"10.1017","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0297-9797","authenticated-orcid":false,"given":"Sirikwun","family":"Umpunthongsiri","sequence":"first","affiliation":[{"name":"Thammasat University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anucha","family":"Apisarnthanarak","sequence":"additional","affiliation":[{"name":"Thammasat University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Potjanee","family":"Srimanote","sequence":"additional","affiliation":[{"name":"Thammasat University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6093-2887","authenticated-orcid":false,"given":"Thana","family":"Khawcharoenporn","sequence":"additional","affiliation":[{"name":"Thammasat University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chayanin","family":"Aungthong","sequence":"additional","affiliation":[{"name":"Thammasat University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narissara","family":"Mungkornkaew","sequence":"additional","affiliation":[{"name":"Thammasat University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9304-5106","authenticated-orcid":false,"given":"Pansachee","family":"Damronglerd","sequence":"additional","affiliation":[{"name":"Thammasat University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasinuch","family":"Rutjanawech","sequence":"additional","affiliation":[{"name":"Thammasat University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9356-2592","authenticated-orcid":false,"given":"Nuntra","family":"Suwantarat","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/002yp7f20","id-type":"ROR","asserted-by":"publisher"}],"name":"Thammasat University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"key":"S2732494X26103544_ref10","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00042-16"},{"key":"S2732494X26103544_ref23","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu957"},{"key":"S2732494X26103544_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2007.05.008"},{"key":"S2732494X26103544_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2009.10.001"},{"key":"S2732494X26103544_ref5","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-015-0043-x"},{"key":"S2732494X26103544_ref26","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw240"},{"key":"S2732494X26103544_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2011.12.003"},{"key":"S2732494X26103544_ref32","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00675-21"},{"key":"S2732494X26103544_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2012.01.002"},{"key":"S2732494X26103544_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2012.02.001"},{"key":"S2732494X26103544_ref21","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3182657916"},{"key":"S2732494X26103544_ref22","doi-asserted-by":"publisher","DOI":"10.1179\/2047773214Y.0000000148"},{"key":"S2732494X26103544_ref9","unstructured":"9. 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Centers for Disease Control and Prevention (CDC). MDRO definition, 2026. https:\/\/www.cdc.gov\/infection-control\/hcp\/mdro-management\/background.html. Accessed February 25, 2026."}],"container-title":["Antimicrobial Stewardship &amp; Healthcare Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S2732494X26103544","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T06:37:36Z","timestamp":1776321456000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S2732494X26103544\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026]]}},"alternative-id":["S2732494X26103544"],"URL":"https:\/\/doi.org\/10.1017\/ash.2026.10354","relation":{},"ISSN":["2732-494X"],"issn-type":[{"value":"2732-494X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"e106"}}