{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:59:28Z","timestamp":1785416368492,"version":"3.56.0"},"reference-count":17,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"unspecified","delay-in-days":179,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ASHE"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S2732494X26104082_as1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To determine the scope and characteristics of healthcare-associated parechovirus-A infection (HA-PI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2732494X26104082_as2\">\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Cross-sectional survey.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2732494X26104082_as3\">\n                    <jats:title>Setting:<\/jats:title>\n                    <jats:p>Hospitals with neonatal units in Japan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2732494X26104082_as4\">\n                    <jats:title>Participants:<\/jats:title>\n                    <jats:p>Patients with parechovirus-A infection in 2023 in Japan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2732494X26104082_as5\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A 2-step questionnaire survey included the primary survey ascertaining the number of patients with HA-PI in 2023, followed by the secondary survey investigating the details of the patients with HA-PI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2732494X26104082_as6\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of the 408 hospitals, 226 (55.4%) responded. Seven sporadic patients were reported from 6 (2.7%) hospitals between May and September 2023, diagnosed as having sepsis (n = 5) or sepsis-like illness (n = 2). The median gestational age was 37.7 weeks (IQR, 36.2\u201338.3). They were second-born (n = 6) or third-born (n = 1), without first-born. The median days of onset of illness were 7 days (IQR, 6\u201315). The locations were the newborn nursery (n = 3), growth care (n = 3), or neonatal intensive care units (n = 1). No sequelae were found at least 10 months in all patients. Parechovirus-A genotype analyses demonstrated A3 (n = 6) and unknown (n = 1). The identified sources of infection were from the mother (n = 5) or unknown (n = 2). Among the 5 mothers, 2 were symptomatic. Notably, the siblings of patients in 3 asymptomatic mothers, who had no direct contact with the patients, were all symptomatic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2732494X26104082_as7\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This nationwide survey in Japan demonstrated HA-PI can occur in neonatal units, with potential risks for nosocomial outbreaks. Suspecting HA-PI and preventive measures are critical in neonatal units.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/ash.2026.10408","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T09:24:05Z","timestamp":1782725045000},"source":"Crossref","is-referenced-by-count":0,"title":["Healthcare-associated parechovirus-A infection in hospitals with neonatal units in Japan: a nationwide survey"],"prefix":"10.1017","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0617-6456","authenticated-orcid":false,"given":"Yuta","family":"Aizawa","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04ww21r56","id-type":"ROR","asserted-by":"publisher"}],"name":"Niigata University Graduate School of Medical and Dental Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5685-2670","authenticated-orcid":false,"given":"Ichiro","family":"Morioka","sequence":"additional","affiliation":[{"name":"Nihon University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Takahashi","sequence":"additional","affiliation":[{"name":"The University of Tokyo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Saitoh","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04ww21r56","id-type":"ROR","asserted-by":"publisher"}],"name":"Niigata University Graduate School of Medical and Dental Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"S2732494X26104082_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2019.09.019"},{"key":"S2732494X26104082_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.05.054"},{"key":"S2732494X26104082_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2015.07.300"},{"key":"S2732494X26104082_ref7","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000180471.03702.7f"},{"key":"S2732494X26104082_ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s40588-023-00197-3"},{"key":"S2732494X26104082_ref17","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piy079"},{"key":"S2732494X26104082_ref4","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2023.142"},{"key":"S2732494X26104082_ref11","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piaf100"},{"key":"S2732494X26104082_ref15","doi-asserted-by":"publisher","DOI":"10.1111\/ped.13470"},{"key":"S2732494X26104082_ref12","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.01139-23"},{"key":"S2732494X26104082_ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-024-04950-4"},{"key":"S2732494X26104082_ref10","doi-asserted-by":"publisher","DOI":"10.1111\/ped.12869"},{"key":"S2732494X26104082_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2017.04.009"},{"key":"S2732494X26104082_ref9","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2023.120"},{"key":"S2732494X26104082_ref13","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000149131.72248.E6"},{"key":"S2732494X26104082_ref1","unstructured":"1. The Pirbright Institute UK. Picornavirus Home. website. https:\/\/www.picornaviridae.com. Accessed November 13, 2025."},{"key":"S2732494X26104082_ref5","doi-asserted-by":"publisher","DOI":"10.3201\/eid2209.151497"}],"container-title":["Antimicrobial Stewardship &amp; Healthcare Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S2732494X26104082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T09:24:15Z","timestamp":1782725055000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S2732494X26104082\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026]]}},"alternative-id":["S2732494X26104082"],"URL":"https:\/\/doi.org\/10.1017\/ash.2026.10408","relation":{},"ISSN":["2732-494X"],"issn-type":[{"value":"2732-494X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"e191"}}