{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:54:37Z","timestamp":1785412477929,"version":"3.56.0"},"reference-count":9,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"unspecified","delay-in-days":147,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ASHE"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S2732494X26104094_as1\">\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To evaluate feasibility of establishing syndromic respiratory virus surveillance in a network of U.S. nursing homes, using CLIA-waived point-of-care (POC) molecular PCR testing, with centrally delivered results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2732494X26104094_as2\">\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Single-arm feasibility pilot study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2732494X26104094_as3\">\n                    <jats:title>Setting and Participants:<\/jats:title>\n                    <jats:p>Twenty-three nursing homes (NHs) in six U.S. states, representing approximately 2,500 residents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2732494X26104094_as4\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A CLIA-waived POC molecular PCR testing device was implemented for on-site testing of respiratory syncytial virus (RSV), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and influenza A and B from collected nasal swabs. Symptom data was entered at the time of testing. Test results were transmitted to a centralized, web-based dashboard providing near real-time surveillance from November 2023 to January 2025. Surveys of NH staff assessed device usability, workflow integration, impact on testing procedures, and infection and outbreak awareness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2732494X26104094_as5\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The established syndromic respiratory virus surveillance network conducted 1,745 point-of-care tests between November 2023 and January 2025, identifying 360 infections, including 160 COVID-19, 115 influenza A and B, and 81 RSV infections. Symptom data was captured for 99.5% of tests. Implementation was associated with high data completeness and integration into facility testing workflows. Staff reported an impact on testing protocols, infection awareness, and time to diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2732494X26104094_as6\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Implementation of a CLIA-waived POC molecular testing device with centralized reporting was feasible across a geographically diverse NH network. The system achieved high data capture, identified substantial viral activity, and demonstrated value for clinical management using real-time diagnostic results. This approach can be adapted for local, regional, or national real-time reporting or future pragmatic interventional studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/ash.2026.10409","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T11:03:36Z","timestamp":1779966216000},"source":"Crossref","is-referenced-by-count":0,"title":["Respiratory surveillance through point of care molecular testing and its impacts on nursing home RSV, influenza, and SARS-CoV-2 awareness and reporting behavior: a pilot study."],"prefix":"10.1017","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7924-0140","authenticated-orcid":false,"given":"H. Edward","family":"Davidson","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0551a9d91","id-type":"ROR","asserted-by":"publisher"}],"name":"Insight Therapeutics LLC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9451-084X","authenticated-orcid":false,"given":"Lisa F.","family":"Han","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0551a9d91","id-type":"ROR","asserted-by":"publisher"}],"name":"Insight Therapeutics LLC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5056-0431","authenticated-orcid":false,"given":"Kevin W.","family":"McConeghy","sequence":"additional","affiliation":[{"name":"Veterans Affairs Providence Health Care System"},{"name":"Brown University School of Public Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4311-7392","authenticated-orcid":false,"given":"Ivis","family":"Perez","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0551a9d91","id-type":"ROR","asserted-by":"publisher"}],"name":"Insight Therapeutics LLC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0140-539X","authenticated-orcid":false,"given":"Elizabeth A.","family":"Sillman","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0551a9d91","id-type":"ROR","asserted-by":"publisher"}],"name":"Insight Therapeutics LLC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9825-8824","authenticated-orcid":false,"given":"Clare","family":"Nugent","sequence":"additional","affiliation":[{"name":"Brown University Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1836-8784","authenticated-orcid":false,"given":"Tiffany","family":"Wallace","sequence":"additional","affiliation":[{"name":"Brown University Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3843-6332","authenticated-orcid":false,"given":"Laurel","family":"Holland","sequence":"additional","affiliation":[{"name":"Brown University Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1915-4339","authenticated-orcid":false,"given":"Evan","family":"Dickerson","sequence":"additional","affiliation":[{"name":"Brown University Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5503-7888","authenticated-orcid":false,"given":"David H.","family":"Canaday","sequence":"additional","affiliation":[{"name":"Case Western Reserve University"},{"name":"Louis Stokes Cleveland VA Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6000-6859","authenticated-orcid":false,"given":"Stefan","family":"Gravenstein","sequence":"additional","affiliation":[{"name":"Brown University School of Public Health"},{"name":"Warren Alpert Medical School of Brown University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7062-6920","authenticated-orcid":false,"given":"Yasin","family":"Abul","sequence":"additional","affiliation":[{"name":"Warren Alpert Medical School of Brown University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"S2732494X26104094_ref4","first-page":"158","article-title":"COVID-19 pandemic in long-term care: An international perspective for policy considerations","volume":"10","author":"Grinspun","year":"2023","journal-title":"Int J Nurs Sci"},{"key":"S2732494X26104094_ref1","doi-asserted-by":"publisher","DOI":"10.15620\/cdc\/158328"},{"key":"S2732494X26104094_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2020.11.022"},{"key":"S2732494X26104094_ref7","first-page":"46958018778902","article-title":"Nursing home implementation of health information technology: review of the literature finds inadequate investment in preparation, infrastructure, and training","volume":"55","author":"Ko","year":"2018","journal-title":"Inq J Med Care Organ Provis Financ"},{"key":"S2732494X26104094_ref9","doi-asserted-by":"publisher","DOI":"10.2196\/37482"},{"key":"S2732494X26104094_ref2","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-023-04300-7"},{"key":"S2732494X26104094_ref6","unstructured":"6. Impact of COVID-19 on Nursing Homes. 2023 national healthcare quality and disparities report. Agency for healthcare research and quality (US), 2023. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK600464\/ Accessed February 13, 2026."},{"key":"S2732494X26104094_ref5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0293336"},{"key":"S2732494X26104094_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2023.09.002"}],"container-title":["Antimicrobial Stewardship &amp; Healthcare Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S2732494X26104094","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T11:03:39Z","timestamp":1779966219000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S2732494X26104094\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":9,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026]]}},"alternative-id":["S2732494X26104094"],"URL":"https:\/\/doi.org\/10.1017\/ash.2026.10409","relation":{},"ISSN":["2732-494X"],"issn-type":[{"value":"2732-494X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"e155"}}