{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:50:45Z","timestamp":1785408645952,"version":"3.56.0"},"reference-count":18,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"unspecified","delay-in-days":200,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ASHE"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S2732494X26107487_as1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study addresses treatment of intra-amniotic infection (IAI) by comparing timely receipt of recommended antibiotic administration between cefoxitin and traditional antimicrobial therapy, ampicillin and gentamicin, with or without clindamycin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2732494X26107487_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective cohort study was conducted at a large, multi-site health system. The combination therapy group treated with ampicillin plus gentamicin, with or without clindamycin from June 2022 to May 2023, was compared to patients treated with cefoxitin from June 2023 to May 2024, following an institutional guideline update.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2732494X26107487_as3\">\n                    <jats:title>Participants:<\/jats:title>\n                    <jats:p>Pregnant individuals aged 16 and older with diagnosed or presumed IAI were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2732494X26107487_as4\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Three hundred patients were included, 150 each in both the combination therapy and cefoxitin groups. Baseline characteristics were similar between the combination therapy and cefoxitin patients. Vaginal delivery was the most common mode of delivery, and rates of cesarean delivery were similar between groups. Most patients had a negative group B\n                      <jats:italic>Streptococcus<\/jats:italic>\n                      screen. Timely receipt of antimicrobials within 60\u201390 minutes of order entry occurred in significantly more patients in the cefoxitin group compared to combination therapy group (69.3% vs 4.7%,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001). Time to recommended therapy was significantly shorter in the cefoxitin group (76.4 \u00b1 93.3 vs 183.7 \u00b1 228.9 min,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001). There were no differences in mortality, 30-day infection-related readmission, or need for additional surgical\/procedural intervention.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2732494X26107487_as5\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Cefoxitin for IAI significantly improves timeliness of recommended antibiotic treatment, aligning with current guideline recommendations for prompt therapy. The absence of differences in secondary outcomes supports the clinical efficacy of cefoxitin and its consideration as a first-line agent in the management of IAI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/ash.2026.10748","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T08:41:17Z","timestamp":1784536877000},"source":"Crossref","is-referenced-by-count":0,"title":["Time to antibiotic administration in intra-amniotic infections: impact of cefoxitin monotherapy versus traditional antibiotic therapy"],"prefix":"10.1017","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6843-6961","authenticated-orcid":false,"given":"Hannah","family":"Bischoff","sequence":"first","affiliation":[{"name":"UH Rainbow Babies & Children\u2019s: UH Rainbow Babies and Children\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5973-1823","authenticated-orcid":false,"given":"Sarah Tennant","family":"Withers","sequence":"additional","affiliation":[{"name":"Prisma Health Upstate"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9097-5980","authenticated-orcid":false,"given":"Caroline","family":"Jozefczyk","sequence":"additional","affiliation":[{"name":"Prisma Health Upstate"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Kohn","sequence":"additional","affiliation":[{"name":"Prisma Health Midlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5373-2391","authenticated-orcid":false,"given":"R. Jake","family":"Crocker","sequence":"additional","affiliation":[{"name":"Prisma Health Upstate"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine","family":"Lewis","sequence":"additional","affiliation":[{"name":"Prisma Health Upstate"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Ellison","sequence":"additional","affiliation":[{"name":"Prisma Health Midlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Ewing","sequence":"additional","affiliation":[{"name":"Prisma Health Upstate"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6953-8955","authenticated-orcid":false,"given":"Pamela","family":"Bailey","sequence":"additional","affiliation":[{"name":"Prisma Health Midlands"},{"id":[{"id":"https:\/\/ror.org\/02b6qw903","id-type":"ROR","asserted-by":"publisher"}],"name":"University of South Carolina School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,7,20]]},"reference":[{"key":"S2732494X26107487_ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000506906"},{"key":"S2732494X26107487_ref6","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05794-11"},{"key":"S2732494X26107487_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2024.02.290"},{"key":"S2732494X26107487_ref13","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofac460"},{"key":"S2732494X26107487_ref16","first-page":"371","article-title":"Cefoxitin versus clindamycin and gentamicin in the treatment of postcesarean section infections","volume":"67","author":"Herman","year":"1986","journal-title":"Obstet Gynecol"},{"key":"S2732494X26107487_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(11)91648-2"},{"key":"S2732494X26107487_ref12","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1215341"},{"key":"S2732494X26107487_ref10","first-page":"1","volume-title":"National healthcare safety network patient safety component manual","year":"2024"},{"key":"S2732494X26107487_ref11","first-page":"1","article-title":"Kidney disease: improving global outcomes (KDIGO) acute kidney injury work group. KDIGO clinical practice guideline for acute kidney injury","volume":"2","author":"Kellum","year":"2012","journal-title":"Kidney Inter Suppl"},{"key":"S2732494X26107487_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2005.07.003"},{"key":"S2732494X26107487_ref17","first-page":"760","article-title":"Comparative efficacy and safety of mezlocillin, cefoxitin, and clindamycin plus gentamicin in postpartum endometritis","volume":"69","author":"Faro","year":"1987","journal-title":"Obstet Gynecol"},{"key":"S2732494X26107487_ref8","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciae042"},{"key":"S2732494X26107487_ref4","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003568"},{"key":"S2732494X26107487_ref9","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000005337"},{"key":"S2732494X26107487_ref1","first-page":"628362","article-title":"A first look at chorioamnionitis management practice variation among US obstetricians","volume":"2012","author":"Greenburg","year":"2012","journal-title":"Infect Dis Obstet Gynecol"},{"key":"S2732494X26107487_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(88)80214-9"},{"key":"S2732494X26107487_ref5","doi-asserted-by":"publisher","DOI":"10.1002\/mbo3.70087"},{"key":"S2732494X26107487_ref2","unstructured":"2. American College of Obstetricians and Gynecologists\u2019 Committee on Obstetric Practice. Intrapartum management of intraamniotic infection. https:\/\/www.acog.org\/en\/clinical\/clinical-guidance\/committee-opinion\/articles\/2017\/08\/intrapartum-management-of-intraamniotic-infection. Accessed August 24, 2024."}],"container-title":["Antimicrobial Stewardship &amp; Healthcare Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S2732494X26107487","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T08:41:20Z","timestamp":1784536880000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S2732494X26107487\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":18,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026]]}},"alternative-id":["S2732494X26107487"],"URL":"https:\/\/doi.org\/10.1017\/ash.2026.10748","relation":{},"ISSN":["2732-494X"],"issn-type":[{"value":"2732-494X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"e218"}}