{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:59:28Z","timestamp":1785419968412,"version":"3.56.0"},"reference-count":21,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"unspecified","delay-in-days":187,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ASHE"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S2732494X26107773_as1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Inappropriate antibiotic allergy labeling often leads to the unnecessary avoidance of first-line therapies. The present study aimed to evaluate the current status of antibiotic allergy documentation and its assessment in patients undergoing surgery for which cefazolin was the recommended first-line prophylaxis in a Japanese hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2732494X26107773_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective observational study was conducted at a university hospital in Tokyo from 2021 to 2023; included patients with a history of antimicrobial allergy who underwent surgery for which cefazolin was recommended; and assessed patient demographics, details of the allergies in electronic health records (EHR), and perioperatively administered antimicrobial agents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2732494X26107773_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of 2,402 eligible patients, 243 (10.1%) had a registered antimicrobial allergy. The drug classes most frequently recorded in the EHR were cephalosporins (25.0%) and penicillins (24.0%). Documentation of allergy assessments by a physician (9.0%) or specialist (7.0%) was rare. Although 51.9% of the labeled patients had received cefazolin, non-first-line agents had also been frequently administered. Notably, clindamycin had been administered to 30% of the cases and had been widely used even among patients with only a penicillin allergy label despite the low risk of cross-reactivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S2732494X26107773_as4\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Antibiotic allergy labels in the EHR were often incomplete, infrequently assessed, and associated with substantial avoidance of first-line prophylaxis. Redesigning the EHR format to allow allergies to be distinguished from adverse events while retaining the standard evaluation pathways is essential to optimizing perioperative antimicrobial stewardship.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/ash.2026.10777","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T10:37:06Z","timestamp":1783420626000},"source":"Crossref","is-referenced-by-count":0,"title":["Current status and challenges in the assessment of antibiotic allergy information in electronic health records: a retrospective observational study of perioperative patients"],"prefix":"10.1017","volume":"6","author":[{"given":"Yui","family":"Enatsu","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05dqf9946","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Science Tokyo Hospital"},{"name":"Institute of Science Tokyo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3736-4046","authenticated-orcid":false,"given":"Yasuaki","family":"Tagashira","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05dqf9946","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Science Tokyo Hospital"},{"name":"Institute of Science Tokyo"},{"name":"Institute of Science Tokyo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4072-9096","authenticated-orcid":false,"given":"Koh","family":"Okamoto","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05dqf9946","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Science Tokyo Hospital"},{"name":"Institute of Science Tokyo"},{"name":"Institute of Science Tokyo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akane","family":"Takamatsu","sequence":"additional","affiliation":[{"name":"Institute of Science Tokyo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2509-1052","authenticated-orcid":false,"given":"Yoshiaki","family":"Gu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05dqf9946","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Science Tokyo Hospital"},{"name":"Institute of Science Tokyo"},{"name":"Institute of Science Tokyo"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"S2732494X26107773_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2020.05.042"},{"key":"S2732494X26107773_ref3","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix794"},{"key":"S2732494X26107773_ref7","doi-asserted-by":"publisher","DOI":"10.1093\/jamia\/ocv139"},{"key":"S2732494X26107773_ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-014-0476-y"},{"key":"S2732494X26107773_ref13","first-page":"1223","article-title":"Evaluation of antibiotic allergies in pregnant women in Japan","volume":"72","author":"Hirai","year":"2023","journal-title":"Arerugi"},{"key":"S2732494X26107773_ref9","doi-asserted-by":"publisher","DOI":"10.3389\/falgy.2022.1059321"},{"key":"S2732494X26107773_ref6","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix244"},{"key":"S2732494X26107773_ref10","first-page":"310","article-title":"Practical guideline for appropriate use of antimicrobial agents to prevent postoperative infections","volume":"68","year":"2020","journal-title":"Jpn J Chemother"},{"key":"S2732494X26107773_ref4","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k2400"},{"key":"S2732494X26107773_ref2","volume-title":"Global Guidelines for the Prevention of Surgical Site Infection","year":"2016"},{"key":"S2732494X26107773_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.06.017"},{"key":"S2732494X26107773_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60621-7"},{"key":"S2732494X26107773_ref19","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.9820"},{"key":"S2732494X26107773_ref8","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.19283"},{"key":"S2732494X26107773_ref20","unstructured":"20. Centers for Disease Control and Prevention. Global antibiotic stewardship evaluation tool (G-ASET) for inpatient healthcare facilities. Updated June 10, 2022. Accessed January 23, 2026."},{"key":"S2732494X26107773_ref12","first-page":"S237","article-title":"The prevalence and factors of antibiotic allergy label in Japan","volume":"10","author":"Adachi","year":"2023","journal-title":"Open Forum Infect Dis"},{"key":"S2732494X26107773_ref1","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp120568"},{"key":"S2732494X26107773_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2023.06.012"},{"key":"S2732494X26107773_ref16","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofad224"},{"key":"S2732494X26107773_ref17","doi-asserted-by":"publisher","DOI":"10.1017\/ash.2024.68"},{"key":"S2732494X26107773_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2011.05.035"}],"container-title":["Antimicrobial Stewardship &amp; Healthcare Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S2732494X26107773","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T10:37:12Z","timestamp":1783420632000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S2732494X26107773\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026]]}},"alternative-id":["S2732494X26107773"],"URL":"https:\/\/doi.org\/10.1017\/ash.2026.10777","relation":{},"ISSN":["2732-494X"],"issn-type":[{"value":"2732-494X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"e205"}}