{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T08:48:52Z","timestamp":1785833332218,"version":"3.56.0"},"reference-count":14,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"unspecified","delay-in-days":215,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ASHE"],"published-print":{"date-parts":[[2026]]},"abstract":"Abstract<\/jats:title>\n \n Objective:<\/jats:title>\n To investigate the factors associated with mortality and the outcomes of an antimicrobial stewardship program (ASP) in pediatric patients with sepsis.<\/jats:p>\n <\/jats:sec>\n \n Design:<\/jats:title>\n Retrospective cohort study.<\/jats:p>\n <\/jats:sec>\n \n Setting:<\/jats:title>\n A tertiary care teaching hospital in Thailand.<\/jats:p>\n <\/jats:sec>\n \n Patients:<\/jats:title>\n Pediatric patients with sepsis.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n This study reviewed electronic medical records of pediatric patients. A computer-generated random sequence was used to select 240 patients who met the inclusion criteria for the analysis.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Between January 1, 2021, and December 31, 2024, a total of 1,777 patients were enrolled in the ASP. Of 240 eligible patients, males accounted for 56.7% of the cohort, with a median age of 1.0 year (interquartile range 0\u20136). Positive blood cultures were identified in 72 patients (30.0%). ASP interventions identified antibiotic-related problems in 93 patients (38.8%), with primary physicians adhering to ASP recommendations in 55 cases (59.1%). Septic shock was the only factor significantly associated with 30-day mortality (adjusted odds ratio 4.064; 95% confident interval: CI 1.265\u201313.061;\n P<\/jats:italic>\n = .019). Mortality rates were not different between groups regarding ASP compliance or blood culture results. The day of therapy\/1,000 PD for vancomycin and meropenem were significantly lower in the compliance group compared to the non-compliance group (81.9 vs 135.4,\n P<\/jats:italic>\n = .026; and 169.9 vs 260.3,\n P<\/jats:italic>\n = .012, respectively).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Septic shock was the only factor associated with 30-day mortality. ASP help detected antibiotic-related problems and reduced meropenem and vancomycin consumption in pediatric patients with sepsis.<\/jats:p>\n <\/jats:sec>","DOI":"10.1017\/ash.2026.10811","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T08:41:28Z","timestamp":1785832888000},"source":"Crossref","is-referenced-by-count":0,"title":["Factors and outcomes of pediatric sepsis under an antimicrobial stewardship program in a tertiary care teaching hospital in Thailand: a retrospective cohort study"],"prefix":"10.1017","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6579-7458","authenticated-orcid":false,"given":"Theerapong","family":"Seesin","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/028wp3y58","id-type":"ROR","asserted-by":"publisher"}],"name":"Chulalongkorn University Faculty of Pharmaceutical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6965-5537","authenticated-orcid":false,"given":"Suvaporn","family":"Anugulruengkitt","sequence":"additional","affiliation":[{"name":"Chulalongkorn University Faculty of Medicine"},{"name":"Chulalongkorn University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7654-1845","authenticated-orcid":false,"given":"Chankit","family":"Puttilerpong","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/028wp3y58","id-type":"ROR","asserted-by":"publisher"}],"name":"Chulalongkorn University Faculty of Pharmaceutical Sciences"},{"name":"Chulalongkorn University Faculty of Pharmaceutical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"key":"S2732494X26108110_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02724-0"},{"key":"S2732494X26108110_ref13","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00048"},{"key":"S2732494X26108110_ref5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.0179"},{"key":"S2732494X26108110_ref8","doi-asserted-by":"publisher","DOI":"10.1542\/hpeds.2019-0027"},{"key":"S2732494X26108110_ref3","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-019-0659-3"},{"key":"S2732494X26108110_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(96)00236-3"},{"key":"S2732494X26108110_ref11","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001182"},{"key":"S2732494X26108110_ref6","first-page":"e9981","article-title":"Association between culture-negative versus culture-positive sepsis and outcomes of patients admitted to the pediatric intensive care unit","volume":"12","author":"Hazwani","year":"2020","journal-title":"Cureus"},{"key":"S2732494X26108110_ref1","unstructured":"1. Core Elements of Hospital Antibiotic Stewardship Programs. Centers for Disease Control and Prevention website, 2025. https:\/\/www.cdc.gov\/antibiotic-use\/core-elements\/hospital.html. Accessed December 26, 2025."},{"key":"S2732494X26108110_ref4","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-021-02945-0"},{"key":"S2732494X26108110_ref14","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-026-02236-3"},{"key":"S2732494X26108110_ref12","doi-asserted-by":"publisher","DOI":"10.14238\/pi59.4.2019.211-6"},{"key":"S2732494X26108110_ref7","first-page":"352","article-title":"Health and economic impacts of antimicrobial resistant infections in Thailand: a preliminary study","volume":"6","author":"Phumart","year":"2012","journal-title":"J Health Syst Res"},{"key":"S2732494X26108110_ref9","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000002198"}],"container-title":["Antimicrobial Stewardship & Healthcare Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S2732494X26108110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T08:41:30Z","timestamp":1785832890000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S2732494X26108110\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026]]}},"alternative-id":["S2732494X26108110"],"URL":"https:\/\/doi.org\/10.1017\/ash.2026.10811","relation":{},"ISSN":["2732-494X"],"issn-type":[{"value":"2732-494X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"e235"}}