{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T09:30:02Z","timestamp":1789119002127,"version":"build-2803163510"},"reference-count":70,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:00:00Z","timestamp":1727049600000},"content-version":"unspecified","delay-in-days":266,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["206432"],"award-info":[{"award-number":["206432"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anim. welf."],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Russell and Burch\u2019s 1959 original definitions of the 3Rs (replacement, reduction and refinement) are widely used today as standards for the ethical use of non-human animals in research, although they have a number of limitations. Authors and institutions around the world have addressed some of these, coming up in certain cases with more accurate, functional, and up-to-date definitions. However, not only do there still remain limitations needing to be addressed, but some that have been addressed resulted in discrepancies, contradictions, and general confusion as to how best apply the 3Rs in practice. In order to clarify the meaning of the 3Rs and enable more optimal implementation of these principles in animal experimentation, this article provides a theoretical discussion for revised definitions of the original 3Rs via examination of some of their main limitations and inconsistencies. First, we offer up the original definitions as presented in the context of Russell and Burch\u2019s book\n                    <jats:italic>The Principles of Humane Experimental Technique.<\/jats:italic>\n                    Then, we examine the main limitations and present clear specifications and requirements for such revised definitions. After presenting our revised definitions, we conclude with various implications for animal welfare within the context of experimentation.\n                  <\/jats:p>","DOI":"10.1017\/awf.2024.39","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T03:42:38Z","timestamp":1727062958000},"source":"Crossref","is-referenced-by-count":25,"title":["Conceptual foundations for a clarified meaning of the 3Rs principles in animal experimentation"],"prefix":"10.1017","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6554-4821","authenticated-orcid":false,"given":"Edwin","family":"Louis-Maerten","sequence":"first","affiliation":[{"name":"University of Basel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8944-1504","authenticated-orcid":false,"given":"Christian","family":"Rodriguez Perez","sequence":"additional","affiliation":[{"name":"University of Basel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2769-4888","authenticated-orcid":false,"given":"Rosa Maria","family":"Cajiga","sequence":"additional","affiliation":[{"name":"University of Basel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8783-1437","authenticated-orcid":false,"given":"Kirsten","family":"Persson","sequence":"additional","affiliation":[{"name":"University of Basel"},{"name":"University of Veterinary Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4249-7399","authenticated-orcid":false,"given":"Bernice Simone","family":"Elger","sequence":"additional","affiliation":[{"name":"University of Basel"},{"name":"University of Geneva"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2024,9,23]]},"reference":[{"key":"S0962728624000393_r17","first-page":"209","article-title":"The European Partnership for Alternative Approaches to Animal Testing (EPAA): promoting alternative methods in Europe and beyond","volume":"54","author":"Cozigou","year":"2015","journal-title":"Journal of the American Association for Laboratory Animal Science"},{"key":"S0962728624000393_r6","first-page":"144","article-title":"The principles of humane experimental technique: timeless insights and unheeded warnings","volume":"27","author":"Balls","year":"2010","journal-title":"Alternatives to Animal Experimentation"},{"key":"S0962728624000393_r7","doi-asserted-by":"publisher","DOI":"10.1177\/026119291404200506"},{"key":"S0962728624000393_r68","unstructured":"Swiss 3R Competence Centre 2023 The 3Rs principle. 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