{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T16:25:55Z","timestamp":1782923155726,"version":"3.54.5"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2015,2,20]],"date-time":"2015-02-20T00:00:00Z","timestamp":1424390400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CJEM"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1481803514000529_abs1\" sec-type=\"general\"><jats:title>Objective<\/jats:title><jats:p>To perform a review and meta-analysis on the effect of antibiotics on treatment of skin and soft tissue abscesses (SSTAs) after incision and drainage.<\/jats:p><\/jats:sec><jats:sec id=\"S1481803514000529_abs2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>We searched MEDLINE, EMBASE, Web of Knowledge, and Google Scholar databases to identify randomized controlled trials (RCTs) and observational studies. For RCTs, we included studies comparing any antibiotic (treatment) to placebo (control). For observational studies, treatment was the use of appropriate antibiotics effective against bacterial isolate, and control was the use of inappropriate (ineffective) or no antibiotics. Outcome was treatment success during follow-up. Two investigators reviewed records, assessed quality (according to Cochrane and Newcastle-Ottawa tools), and extracted treatment success rates. Primary analysis was the effect of treatment among RCTs. Secondary analyses included the effect of treatment in 1) observational studies of confirmed methicillin-resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (MRSA) infection (MRSA-only) and 2) all studies after 1998 (MRSA-era). We used random effects modelling, except when no heterogeneity was present when we used fixed effects.<\/jats:p><\/jats:sec><jats:sec id=\"S1481803514000529_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>We screened 1,968 records. Twelve were included (five RCTs, seven observational studies), representing 1,969 subjects. Seven enrolled from emergency departments, two from surgical clinics, and three from ambulatory clinics. Three enrolled children only. Pooled relative risk (RR) of treatment success among RCTs was 1.03 (95% confidence interval [CI] 0.97\u22121.08). Pooled RR in the secondary analyses was 1.05 (95% CI 0.96\u22121.15) in MRSA-only and 0.99 (95% CI 0.98\u22121.01) in MRSA-era.<\/jats:p><\/jats:sec><jats:sec id=\"S1481803514000529_abs4\" sec-type=\"conclusion\"><jats:title>Conclusion<\/jats:title><jats:p>Despite limitations in pooling available data, there is no clear evidence to support antibiotic use in treating uncomplicated SSTAs.<\/jats:p><\/jats:sec>","DOI":"10.1017\/cem.2014.52","type":"journal-article","created":{"date-parts":[[2015,2,20]],"date-time":"2015-02-20T07:32:29Z","timestamp":1424417549000},"page":"420-432","source":"Crossref","is-referenced-by-count":29,"title":["The role of adjunctive antibiotics in the treatment of skin and soft tissue abscesses: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"17","author":[{"given":"Jahan","family":"Fahimi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandeep","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley W.","family":"Frazee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,2,20]]},"reference":[{"key":"S1481803514000529_ref16","doi-asserted-by":"publisher","DOI":"10.1002\/9780470712184"},{"key":"S1481803514000529_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2010.04.027"},{"key":"S1481803514000529_ref32","unstructured":"National Institute of Allergy and Infectious Diseases (NIAID). Strategies using off-patent antibiotics for methicillin resistant S. aureus \u201cSTOP MRSA.\u201d Available at: http:\/\/clinicaltrials.gov\/ct2\/show\/NCT00729937 NLM Identifier: NCT00729937 (accessed December 12, 2012)."},{"key":"S1481803514000529_ref20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001026"},{"key":"S1481803514000529_ref33","unstructured":"National Institute of Allergy and Infectious Diseases (NIAID). Uncomplicated skin and soft tissue infections caused by community-associated methicillin-resistant Staphylococcus aureus. Available at: http:\/\/clinicaltrials.gov\/ct2\/show\/NCT00730028 NLM Identifier: NCT00730028 (accessed December 12, 2012)."},{"key":"S1481803514000529_ref17","unstructured":"Wells GA , Shea B , O\u2019Connell D , et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Available at: http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp (accessed August 18, 2013)."},{"key":"S1481803514000529_ref4","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.168.14.1585"},{"key":"S1481803514000529_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2007.01.018"},{"key":"S1481803514000529_ref8","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02311-06"},{"key":"S1481803514000529_ref23","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.epirev.a036298"},{"key":"S1481803514000529_ref6","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir034"},{"key":"S1481803514000529_ref28","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq067"},{"key":"S1481803514000529_ref15","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"S1481803514000529_ref30","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03550110082041"},{"key":"S1481803514000529_ref19","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm189"},{"key":"S1481803514000529_ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055356"},{"key":"S1481803514000529_ref31","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7159.609"},{"key":"S1481803514000529_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2007.12.004"},{"key":"S1481803514000529_ref1","doi-asserted-by":"publisher","DOI":"10.1086\/497143"},{"key":"S1481803514000529_ref27","doi-asserted-by":"publisher","DOI":"10.2307\/2533446"},{"key":"S1481803514000529_ref25","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"S1481803514000529_ref18","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.8.593"},{"key":"S1481803514000529_ref21","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"S1481803514000529_ref11","doi-asserted-by":"publisher","DOI":"10.1136\/emermed-2013-202571"},{"key":"S1481803514000529_ref7","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800640410"},{"key":"S1481803514000529_ref5","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir308"},{"key":"S1481803514000529_ref22","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.1031920"},{"key":"S1481803514000529_ref29","doi-asserted-by":"publisher","DOI":"10.1086\/591126"},{"key":"S1481803514000529_ref12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMclde0806337"},{"key":"S1481803514000529_ref14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"S1481803514000529_ref26","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"S1481803514000529_ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043252"},{"key":"S1481803514000529_ref24","first-page":"971","article-title":"Ethylene oxide: an assessment of the epidemiological evidence on carcinogenicity","volume":"50","author":"Shore","year":"1993","journal-title":"Br J Ind Med"}],"container-title":["CJEM"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1481803514000529","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T23:37:52Z","timestamp":1609457872000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1481803514000529\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,20]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S1481803514000529"],"URL":"https:\/\/doi.org\/10.1017\/cem.2014.52","relation":{},"ISSN":["1481-8035","1481-8043"],"issn-type":[{"value":"1481-8035","type":"print"},{"value":"1481-8043","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,20]]}}}