{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:32:32Z","timestamp":1785414752075,"version":"3.56.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"S2","license":[{"start":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T00:00:00Z","timestamp":1603238400000},"content-version":"unspecified","delay-in-days":50,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CJEM"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec id=\"S1481803519004123_sec_a1\"><jats:title>Objectives<\/jats:title><jats:p>In traumatically injured patients, excessive blood loss necessitating the transfusion of red blood cell (RBC) units is common. Indicators of early RBC transfusion in the pre-hospital setting are needed. This study aims to evaluate the association between hypothermia (&lt;36\u00b0C) and transfusion risk within the first 24 hours after arrival to hospital for a traumatic injury.<\/jats:p><\/jats:sec><jats:sec id=\"S1481803519004123_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>We completed an audit of all traumatically injured patients who had emergent surgery at a single tertiary care center between 2010 and 2014. Using multivariable logistic regression analysis, we evaluated the association between pre-hospital hypothermia and transfusion of \u22651 unit of RBC within 24 hours of arrival to the trauma bay.<\/jats:p><\/jats:sec><jats:sec id=\"S1481803519004123_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Of the 703 patients included to evaluate the association between hypothermia and RBC transfusion, 203 patients (29%) required a transfusion within 24 hours. After controlling for important confounding variables, including age, sex, coagulopathy (platelets and INR), hemoglobin, and vital signs (blood pressure and heart rate), hypothermia was associated with a 68% increased odds of transfusion in multivariable analysis (OR: 1.68; 95% CI: 1.11-2.56).<\/jats:p><\/jats:sec><jats:sec id=\"S1481803519004123_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>Hypothermia is strongly associated with RBC transfusion in a cohort of trauma patients requiring emergent surgery. This finding highlights the importance of early measures of temperature after traumatic injury and the need for intervention trials to determine if strategies to mitigate the risk of hypothermia will decrease the risk of transfusion and other morbidities.<\/jats:p><\/jats:sec>","DOI":"10.1017\/cem.2019.412","type":"journal-article","created":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T14:25:51Z","timestamp":1603290351000},"page":"S12-S20","source":"Crossref","is-referenced-by-count":2,"title":["Pre-hospital hypothermia is associated with transfusion risk after traumatic injury"],"prefix":"10.1007","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4005-7015","authenticated-orcid":false,"given":"Naheed K.","family":"Jivraj","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilia","family":"Kaustov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kennedy Ning","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Strauss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannie","family":"Callum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Homer","family":"Tien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asim Q.","family":"Alam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,10,21]]},"reference":[{"key":"S1481803519004123_ref29","doi-asserted-by":"crossref","first-page":"S186","DOI":"10.1097\/CCM.0b013e3181aa5241","article-title":"Mechanisms of action, physiological effects, and complications of hypothermia","volume":"37","author":"Polderman","year":"2009","journal-title":"Crit Care Med"},{"key":"S1481803519004123_ref32","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.accpm.2016.05.001","article-title":"Accidental hypothermia in severe trauma","volume":"35","author":"Vardon","year":"2016","journal-title":"Anaesth Crit Care Pain Med"},{"key":"S1481803519004123_ref14","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1097\/00000542-199503000-00008","article-title":"Heat flow and distribution during induction of general anesthesia","volume":"82","author":"Matsukawa","year":"1995","journal-title":"Anesthesiology"},{"key":"S1481803519004123_ref25","doi-asserted-by":"crossref","DOI":"10.1186\/cc12851","article-title":"The Shock Index revisited - a fast guide to transfusion requirement? 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