{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:14:01Z","timestamp":1792026841652,"version":"4.4.0"},"reference-count":28,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2014,11,11]],"date-time":"2014-11-11T00:00:00Z","timestamp":1415664000000},"content-version":"unspecified","delay-in-days":10,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0317167114001061_abs1\" sec-type=\"general\"><jats:title>Background<\/jats:title><jats:p>Acromegaly has important effects on quality of life (QOL). This is the first study to measure QOL in acromegalic patients after endoscopic transsphenoidal surgery (ETSS).<\/jats:p><\/jats:sec><jats:sec id=\"S0317167114001061_abs2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>We prospectively collected the RAND-36, Center for Epidemiologic Studies Depression (CES-D), and Pituitary QOL validated questionnaires and patients\u2019 demographics, clinical presentation, endocrine laboratory results, radiological studies, development of complications and remission rates from 20 consecutive acromegalic patients who had undergone endoscopic transphenoidal surgery.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167114001061_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>The eleven females and nine males had an average age of 42 years; 90 percent had macroadenomas and 70% had cavernous sinus invasion on their preoperative imaging. Ninety percent had improved symptoms post-operatively and 80% stated that treatment improved their QOL. Biochemically, 35% were cured, 35% had discordant results and 30% were not cured, while pan-hypopituitarism occurred in 4 patients. Physical health subscales and pituitary-related symptoms were similar to norms. \u201cSocial,\u201d \u201cemotional health,\u201d and \u201cenergy levels\u201d were significantly lower than norms. Seventy percent stated that their relationship with their physician \u201cvery much so\u201d affected their quality of life. Pan hypopituitarism and adjuvant therapy were the most significant predictors of lower QOL subscale scores.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167114001061_abs4\" sec-type=\"conclusion\"><jats:title>Conclusion<\/jats:title><jats:p>Transsphenoidal surgery improves QOL in acromegaly. Attempts to achieve a cure, avoidance of surgically induced pan-hypotpituitarism and adjuvant therapy, will improve quality of life. Our study demonstrates the important role of the patient-physician relationship to QOL and the need to measure QOL in addition to the traditional measures of outcome.<\/jats:p><\/jats:sec>","DOI":"10.1017\/cjn.2014.106","type":"journal-article","created":{"date-parts":[[2014,11,12]],"date-time":"2014-11-12T01:10:46Z","timestamp":1415754646000},"page":"735-741","source":"Crossref","is-referenced-by-count":17,"title":["Endoscopic Transphenoidal Surgery for Acromegaly Improves Quality of Life"],"prefix":"10.1017","volume":"41","author":[{"given":"Hussein","family":"Fathalla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Cusimano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar M.","family":"Alsharif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rowan","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2014,11,11]]},"reference":[{"key":"S0317167114001061_ref27","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.1997.1190659.x"},{"key":"S0317167114001061_ref26","doi-asserted-by":"publisher","DOI":"10.1007\/BF03345477"},{"key":"S0317167114001061_ref16","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2670"},{"key":"S0317167114001061_ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000288641"},{"key":"S0317167114001061_ref4","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-2-13"},{"key":"S0317167114001061_ref12","first-page":"62","article-title":"Cross-sectional study of Quality of Life (QOL) in patients with acromegaly","volume":"4","author":"Rowles","year":"2002","journal-title":"Endocrine Abstracts"},{"key":"S0317167114001061_ref25","doi-asserted-by":"publisher","DOI":"10.1023\/A:1009961116472"},{"key":"S0317167114001061_ref23","first-page":"265","article-title":"Canadian normative data for the SF-36 health survey. 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