{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:42:21Z","timestamp":1789432941314,"version":"build-2803163510"},"reference-count":49,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T00:00:00Z","timestamp":1427241600000},"content-version":"unspecified","delay-in-days":24,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic><jats:bold>Background:<\/jats:bold><\/jats:italic> In the past two decades, there has been increasing evidence to suggest that trigeminal neuralgia (TN) may be linked to a dysfunction of the autonomic nervous system (ANS). The aim of the present study was to formally test this hypothesis by comparing the reactivity of the ANS to experimental pain in a population of TN patients and healthy controls. <jats:italic><jats:bold>Methods:<\/jats:bold><\/jats:italic> Twelve patients diagnosed with classical TN and 12 healthy controls participated in the study. Cardiac activity was assessed while participants were instructed to rest and again during a cold pressor test (CPT). Heart rate variability analyses were performed off-line to obtain parasympathetic (high-frequency) and sympathetic (low-frequency) indices. <jats:italic><jats:bold>Results:<\/jats:bold><\/jats:italic> At baseline, ANS measures did not differ between healthy controls and TN patients, and both groups showed a similar increase in heart rate during the CPT (all p values &gt;0.05). However, TN patients showed a greater increase in cardiac sympathetic activity and a greater decrease in cardiac parasympathetic activity during CPT compared with healthy controls (all p values &lt;0.05). Importantly, changes in sympathetic reactivity, from baseline to CPT, were negatively associated with the number of pain paroxysms experienced each day by TN patients in the preceding week (r=\u2212.58, p&lt;0.05). <jats:italic><jats:bold>Conclusions:<\/jats:bold><\/jats:italic> These results suggest that TN, like many other short-lasting, unilateral facial pain conditions, is linked to ANS alterations. Future studies are required to determine if the altered ANS response observed in TN patients is a cause or a consequence of TN pain<\/jats:p>","DOI":"10.1017\/cjn.2015.10","type":"journal-article","created":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T11:56:09Z","timestamp":1427284569000},"page":"125-131","source":"Crossref","is-referenced-by-count":16,"title":["Altered Autonomic Nervous System Reactivity to Pain in Trigeminal 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