{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T06:40:05Z","timestamp":1718001605037},"reference-count":15,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2015,7,20]],"date-time":"2015-07-20T00:00:00Z","timestamp":1437350400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0317167115002371_abs1\" sec-type=\"general\"><jats:title>Background<\/jats:title><jats:p>The amplitude of the cortically generated somatosensory evoked potential (SSEP) is used to predict outcome in comatose patients. The relationship between epileptiform discharges and SSEP amplitude has not been elucidated in those patients.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167115002371_abs2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>Bilateral median nerve SSEP and electroencephalograph (EEG) studies were performed in a comatose patient (patient 1) 1 day after cardiac surgery and repeated 4 days later. He had tranexamic acid administered before and during surgery. Another comatose patient (patient 2) had the same studies performed 1 day after sustaining 10 minutes of pulseless electrical cardiac activity.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167115002371_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Both comatose patients had epileptiform discharges (on EEG) that were coincident with giant cortically generated SSEPs. In patient 1, the EEG and SSEP studies repeated 5 days postoperatively showed no epileptiform discharges, and the cortically generated SSEP amplitude was decreased (normalized) compared with that obtained one day postoperatively. He emerged from coma and had a good recovery. Patient 2 died shortly after EEG and SSEP testing.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167115002371_abs4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>Epileptiform discharges were associated with giant cortically generated median nerve SSEP amplitude (tranexamic acid was implicated in patient 1 and anoxic brain injury in patient 2). Accordingly, those who use the amplitude of cortically generated SSEPs for predicting outcome in comatose patients should consider the presence of epileptiform discharges (detected by EEG) as a potential confounding factor.<\/jats:p><\/jats:sec>","DOI":"10.1017\/cjn.2015.237","type":"journal-article","created":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T02:50:28Z","timestamp":1437965428000},"page":"317-323","source":"Crossref","is-referenced-by-count":4,"title":["Giant Somatosensory Evoked Potentials Coincident With Epileptiform Discharges in Acutely Comatose Patients"],"prefix":"10.1017","volume":"42","author":[{"given":"David A.","family":"Houlden","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark I.","family":"Boulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian J.","family":"Murray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loretta","family":"Norton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. Bryan","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,7,20]]},"reference":[{"key":"S0317167115002371_ref9","first-page":"143","article-title":"Electrophysiological and pharmacological studies of somatosensory reflex myoclonus","volume":"32","author":"Takeuchi","year":"1992","journal-title":"Electromyogr Clin Neurophysiol"},{"key":"S0317167115002371_ref12","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181c92b23"},{"key":"S0317167115002371_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0987-7053(99)90044-8"},{"key":"S0317167115002371_ref8","first-page":"283","volume-title":"Evoked Potentials in Clinical Medicine","author":"Chiappa","year":"1997"},{"key":"S0317167115002371_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2009.10.100"},{"key":"S0317167115002371_ref3","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181c031b3"},{"key":"S0317167115002371_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2007.11.001"},{"key":"S0317167115002371_ref13","first-page":"271","article-title":"Seizures associated with high cerebrospinal fluid concentrations of cefalozin","volume":"37","author":"Bechtel","year":"1980","journal-title":"Am J Hosp Pharm"},{"key":"S0317167115002371_ref11","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20234"},{"key":"S0317167115002371_ref4","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000227183.21314.cd"},{"key":"S0317167115002371_ref10","first-page":"122","article-title":"The pathophysiology of giant SEPs in cortical myoclonus: a scalp topography and dipolar source modeling study","volume":"104","author":"Valeriani","year":"1997","journal-title":"EEG Clin Neurophysiol"},{"key":"S0317167115002371_ref5","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/ana.21984","article-title":"Prognostication after cardiac arrest and hypothermia: a prospective study","volume":"67","author":"Rossetti","year":"2010","journal-title":"Ann Neurol"},{"key":"S0317167115002371_ref2","doi-asserted-by":"publisher","DOI":"10.1385\/NCC:2:2:159"},{"key":"S0317167115002371_ref6","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/108.1.225"},{"key":"S0317167115002371_ref14","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.301.1.168"}],"container-title":["Canadian Journal of Neurological Sciences \/ Journal Canadien des Sciences Neurologiques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0317167115002371","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T06:02:41Z","timestamp":1717999361000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0317167115002371\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,20]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S0317167115002371"],"URL":"https:\/\/doi.org\/10.1017\/cjn.2015.237","relation":{},"ISSN":["0317-1671","2057-0155"],"issn-type":[{"value":"0317-1671","type":"print"},{"value":"2057-0155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,20]]}}}