{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:37:06Z","timestamp":1778629026093,"version":"3.51.4"},"reference-count":27,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2015,6,5]],"date-time":"2015-06-05T00:00:00Z","timestamp":1433462400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold><jats:italic>Objective:<\/jats:italic><\/jats:bold> The radiological and clinical significance of a dilated Virchow-Robin space (dVRS) in the striatum (STR) remains unclear. We investigated the role of dVRS in STR on parkinsonism and dopamine transporter positron emission tomography (DaT-PET) findings. <jats:bold><jats:italic>Methods:<\/jats:italic><\/jats:bold> Patients with parkinsonism who underwent both brain magnetic resonance imaging and DaT-PET were included. Clinical status was evaluated by Hoehn and Yahr (HY) stage, Korean-Mini Mental Status Examination (K-MMSE), Montreal Cognitive Assessment Korea (MoCA-K), and Frontal Assessment Battery (FAB). dVRS was assessed by semi-quantitative and quantitative scales in each of the three segments of STR (caudate nuclei, anterior and posterior putamen) and was expressed as a dVRS score. DaT-PET was qualitatively assessed as either normal or abnormal in each segment. The relationship between dVRS and DaT-PET abnormality (ab-DaT-PET) was designated in each segment as either concordant or discordant. A concordant segment was defined by the presence of dVRS with ab-DaT-PET [Concordance rate (CR)=number of concordant segments\/number of concordant and discordant segments]. <jats:bold><jats:italic>Results:<\/jats:italic><\/jats:bold> Eleven patients were included. There was no significant correlation between the presence of dVRS and ab-DaT-PET. The mean CR was 0.39. CR was not significantly correlated with any clinical or neuroimaging scales. The dVRS score was significantly correlated with K-MMSE, MoCA-K, and FAB (<jats:italic>r<\/jats:italic>=\u22120.675, \u22120.847, and \u22120.868, respectively) but not with HY stage. <jats:bold><jats:italic>Conclusion:<\/jats:italic><\/jats:bold> dVRS in STR played no significant role on dopaminergic innervation revealed by DaT-PET and made little contribution to clinical parkinsonism; however, it was correlated with cognitive impairment.<\/jats:p>","DOI":"10.1017\/cjn.2015.43","type":"journal-article","created":{"date-parts":[[2015,7,8]],"date-time":"2015-07-08T10:08:03Z","timestamp":1436350083000},"page":"248-254","source":"Crossref","is-referenced-by-count":14,"title":["Dilated Virchow-Robin Space and Dopamine Transporter Imaging in the Striatum of Patients with Parkinsonism"],"prefix":"10.1017","volume":"42","author":[{"given":"Dokyung","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Il Ki","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae-Beom","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,6,5]]},"reference":[{"key":"S0317167115000438_ref17","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000324625.00404.15"},{"key":"S0317167115000438_ref14","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410340331"},{"key":"S0317167115000438_ref7","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870100609"},{"key":"S0317167115000438_ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb04845.x"},{"key":"S0317167115000438_ref25","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70013-4"},{"key":"S0317167115000438_ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-007-0774-9"},{"key":"S0317167115000438_ref12","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19971117)388:2<211::AID-CNE3>3.0.CO;2-4"},{"key":"S0317167115000438_ref8","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8257(200011)15:6<1139::AID-MDS1012>3.0.CO;2-E"},{"key":"S0317167115000438_ref10","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20083"},{"key":"S0317167115000438_ref6","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.3.181"},{"key":"S0317167115000438_ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-012-6598-z"},{"key":"S0317167115000438_ref5","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.6.897"},{"key":"S0317167115000438_ref16","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.51.6.745"},{"key":"S0317167115000438_ref11","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.12009"},{"key":"S0317167115000438_ref9","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000261483.49248.b8"},{"key":"S0317167115000438_ref20","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.564914"},{"key":"S0317167115000438_ref19","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.6.1546"},{"key":"S0317167115000438_ref27","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.09.030186.002041"},{"key":"S0317167115000438_ref2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2003.030858"},{"key":"S0317167115000438_ref23","first-page":"1318","article-title":"European Task Force on Age-Related White Matter Changes","volume":"32","author":"Wahlund","year":"2001","journal-title":"A new rating scale for age-related white matter changes applicable to MRI and CT. 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