{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T10:27:15Z","timestamp":1756636035692},"reference-count":28,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T00:00:00Z","timestamp":1424995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>William Osler\u2019s 1892 textbook <jats:italic>The Principles and Practice of Medicine<\/jats:italic> became the dominant medical text in the English-speaking world. Osler was labeled a therapeutic nihilist by some. The topic of migraine, including treatment, was succinctly covered in his text. The objectives of this study were to review Osler\u2019s thoughts on migraine, and outline his therapeutic recommendations. Preventively Osler mentioned bromides, iron, arsenic, nitroglycerin, and cannabis. Acutely he recommended coffee, chloroform, cannabis, antipyrin, antifebrin, phenacetin, caffeine citrate, nux vomica, or ergot. He thought cannabis was the most satisfactory remedy. Osler was not a therapeutic nihilist when it came to migraine, and his treatment recommendations were similar to other writers of his time. Osler did not draw upon his personal experience to contribute new knowledge about migraine. Regardless, given the popularity and clarity of his text, Osler\u2019s well-summarized migraine chapter had a great influence on practicing physicians.<\/jats:p>","DOI":"10.1017\/cjn.2015.6","type":"journal-article","created":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T07:21:47Z","timestamp":1425021707000},"page":"144-147","source":"Crossref","is-referenced-by-count":7,"title":["Osler on Migraine"],"prefix":"10.1017","volume":"42","author":[{"given":"Christopher J.","family":"Boes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,2,27]]},"reference":[{"key":"S0317167115000062_ref13","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws020"},{"key":"S0317167115000062_ref18","volume-title":"A system of practical medicine","author":"Pepper","year":"1885"},{"key":"S0317167115000062_ref15","volume-title":"A catalogue of the scientific and literary work of S. 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Cushing Papers, McGill University: Osler Library, Bibliotheca Osleriana 2783; 1915:1970."},{"key":"S0317167115000062_ref17","first-page":"69","article-title":"Osler\u2019s prescriptions and materia medica","volume":"35","author":"Macht","year":"1936","journal-title":"Trans Am Ther Soc"},{"key":"S0317167115000062_ref2","first-page":"174","article-title":"A System of Practical Medicine by American authors (unsigned book review)","volume":"xciii","author":"Osler","year":"1887","journal-title":"Am J Med Sci"},{"key":"S0317167115000062_ref12","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2002.00422.x"},{"key":"S0317167115000062_ref3","volume-title":"A history of William Osler's The principles and practice of medicine","author":"Golden","year":"2004"},{"key":"S0317167115000062_ref6","volume-title":"The principles and practice of medicine: designed for the use of practitioners and students of medicine","author":"Osler","year":"1892"},{"key":"S0317167115000062_ref7","volume-title":"The principles and practice of medicine: designed for the use of practitioners and students of medicine","author":"Osler","year":"1912"},{"key":"S0317167115000062_ref22","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq090"},{"key":"S0317167115000062_ref25","unstructured":"William Gowers to William Osler. Cushing Papers, McGill University: Osler Library, Bibliotheca Osleriana 3562; 1894:384."},{"key":"S0317167115000062_ref24","unstructured":"William Gowers to Silas Weir Mitchell. Cushing Papers: Yale University Library; 1884:398."},{"key":"S0317167115000062_ref23","first-page":"734","article-title":"Notes and comments","volume":"xvi","author":"Osler","year":"1888","journal-title":"Can Med Surg J"},{"key":"S0317167115000062_ref11","volume-title":"On megrim, sick-headache, and some allied disorders: a contribution to the pathology of nerve-storms","author":"Liveing","year":"1873"},{"key":"S0317167115000062_ref26","unstructured":"William Gowers to William Osler. Cushing Papers, McGill University: Osler Library, Bibliotheca Osleriana 2786; 1912:1191."},{"key":"S0317167115000062_ref16","first-page":"120","article-title":"Silas Weir Mitchell","volume":"i","author":"Osler","year":"1914","journal-title":"BMJ"},{"key":"S0317167115000062_ref21","volume-title":"Opera minora; a collection of essays, articles, lectures and addresses from 1866 to 1882 inclusive","author":"Seguin","year":"1884"},{"key":"S0317167115000062_ref1","volume-title":"William Osler: a life in medicine","author":"Bliss","year":"1999"},{"key":"S0317167115000062_ref20","doi-asserted-by":"publisher","DOI":"10.1093\/med\/9780199860975.001.0001"},{"key":"S0317167115000062_ref19","doi-asserted-by":"crossref","DOI":"10.2307\/1411377","volume-title":"A Manual of Diseases of the Nervous System","author":"Gowers","year":"1888"},{"key":"S0317167115000062_ref5","first-page":"51","volume-title":"First edition: \u201cthe given word\u201d. 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