{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:43:47Z","timestamp":1787773427867,"version":"build-2784847793"},"reference-count":17,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T00:00:00Z","timestamp":1499040000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2017,9]]},"abstract":"Abstract<\/jats:title>Background:<\/jats:bold><\/jats:italic> Preliminary studies have supported the utility of exercise as a treatment for Charcot\u2013Marie\u2013Tooth disease (CMT) patients. Despite being the most common inherited neuropathy, there remains a paucity of guidelines for CMT management. Methods:<\/jats:bold><\/jats:italic> A retrospective chart review was performed on 297 CMT patients. Self-reported exercise and strength results from standardized dynamometer testing were obtained from adult patients\u2019 first visits. Values were converted and analyzed based on previously reported age- and sex-matched normative values. Results:<\/jats:bold><\/jats:italic> Participants with CMT2 had greater strength values than those with CMT1 in hand grip, elbow flexion, and dorsiflexion (p<\/jats:italic><0.05). Participants with CMT1 and CMT2 who exercised were statistically significantly stronger in elbow flexion and dorsiflexion than those who did not exercise. Conclusions:<\/jats:bold><\/jats:italic> These preliminary results suggest that self-directed exercise is associated with greater strength in CMT patients of both CMT1 and CMT2 subtypes. Self-directed exercise may be a convenient, sustainable, and effective method of improving strength and decreasing disability in this population. Future research should explore the type of exercise prescription that best addresses the needs of the CMT population.<\/jats:p>","DOI":"10.1017\/cjn.2017.204","type":"journal-article","created":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T01:58:17Z","timestamp":1499047097000},"page":"572-576","source":"Crossref","is-referenced-by-count":5,"title":["Effects of Self-Selected Exercise on Strength in Charcot\u2013Marie\u2013Tooth Disease Subtypes"],"prefix":"10.1017","volume":"44","author":[{"given":"Djurdja","family":"Djordjevic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Fell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2017,7,3]]},"reference":[{"key":"S0317167117002049_ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-011-0115-z"},{"key":"S0317167117002049_ref14","doi-asserted-by":"publisher","DOI":"10.5014\/ajot.40.10.705"},{"key":"S0317167117002049_ref2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.5.813"},{"key":"S0317167117002049_ref9","doi-asserted-by":"publisher","DOI":"10.1111\/jns.12116"},{"key":"S0317167117002049_ref17","doi-asserted-by":"publisher","DOI":"10.1385\/NMM:8:1-2:3"},{"key":"S0317167117002049_ref15","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000176062.44360.49"},{"key":"S0317167117002049_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S1836-9553(10)70041-2"},{"key":"S0317167117002049_ref7","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-307598"},{"key":"S0317167117002049_ref13","first-page":"69","article-title":"Grip and pinch strength: normative data for adults","volume":"66","author":"Mathiowetz","year":"1985","journal-title":"Arch Phys Med Rehabil"},{"key":"S0317167117002049_ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03037.x"},{"key":"S0317167117002049_ref16","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.70.4.548"},{"key":"S0317167117002049_ref8","doi-asserted-by":"publisher","DOI":"10.1097\/00002060-200211001-00013"},{"key":"S0317167117002049_ref3","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21140"},{"key":"S0317167117002049_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-8966(01)00193-6"},{"key":"S0317167117002049_ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-011-1975-3"},{"key":"S0317167117002049_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2006.08.006"},{"key":"S0317167117002049_ref10","unstructured":"Turna J , Baker S , Igdoura S . The effects of endurance and strength training on physical performance and quality-of-life of patients with Charcot\u2013Marie\u2013Tooth (CMT) disease [abstract]. In: 8th Annual Biology Undergraduate Symposium, presented by the Department of Biology, McMaster University, Hamilton, Ontario; 2012."}],"container-title":["Canadian Journal of Neurological Sciences \/ Journal Canadien des Sciences Neurologiques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0317167117002049","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T01:33:51Z","timestamp":1555464831000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0317167117002049\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,3]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["S0317167117002049"],"URL":"https:\/\/doi.org\/10.1017\/cjn.2017.204","relation":{},"ISSN":["0317-1671","2057-0155"],"issn-type":[{"value":"0317-1671","type":"print"},{"value":"2057-0155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,3]]}}}