{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T07:11:50Z","timestamp":1780989110865,"version":"3.54.1"},"reference-count":10,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T00:00:00Z","timestamp":1510099200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Some nonmotor symptoms (NMS) of Parkinson\u2019s disease (PD) have been shown to increase the risk of developing dementia. A total of 52 PD patients without dementia at baseline were examined for NMS over 36 months. Mini-Mental State Examination, Dementia Rating Scale\u20132, and caregiver-derived (Clinical Dementia Rating) scores were employed to rate patients as having either clear progression or not. Some 20 of 48 participants (41.7%) had clear cognitive decline. Univariate binary regression analysis was statistically significant for age (odds ratio [<jats:italic>OR<\/jats:italic>] (<jats:italic>CI<\/jats:italic><jats:sub>95%<\/jats:sub>)=1.24, 1.07\u20131.45, <jats:italic>p<\/jats:italic>=0.006) and orthostatic hypotension (OH) (<jats:italic>OR<\/jats:italic> (<jats:italic>CI<\/jats:italic><jats:sub>95%<\/jats:sub>)=4.91, 1.24\u201319.5, <jats:italic>p<\/jats:italic>=0.024). Multivariate analysis showed that only age (<jats:italic>OR<\/jats:italic> (<jats:italic>CI<\/jats:italic><jats:sub>95%<\/jats:sub>)=1.19, 1.0\u20131.41, <jats:italic>p<\/jats:italic>=0.05) and OH (<jats:italic>OR<\/jats:italic> (<jats:italic>CI<\/jats:italic><jats:sub>95%<\/jats:sub>)=5.57, 1.0\u201330.97, <jats:italic>p<\/jats:italic>=0.05) were correlated with an increased risk of cognitive decline. The presence of OH at baseline may be a significant predictor of progression to dementia in PD.<\/jats:p>","DOI":"10.1017\/cjn.2017.239","type":"journal-article","created":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T05:24:04Z","timestamp":1510118644000},"page":"97-99","source":"Crossref","is-referenced-by-count":10,"title":["Nonmotor Symptoms of Parkinson\u2019s Disease as Predictors of Dementia"],"prefix":"10.1017","volume":"45","author":[{"given":"Mohammed Wasif","family":"Hussain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Camicioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2017,11,8]]},"reference":[{"key":"S0317167117002396_ref8","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.62.2.181"},{"key":"S0317167117002396_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70373-8"},{"key":"S0317167117002396_ref7","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23700"},{"key":"S0317167117002396_ref9","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.4.455"},{"key":"S0317167117002396_ref3","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22843"},{"key":"S0317167117002396_ref10","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2016-314123"},{"key":"S0317167117002396_ref2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr321"},{"key":"S0317167117002396_ref5","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-160925"},{"key":"S0317167117002396_ref6","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26632"},{"key":"S0317167117002396_ref4","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000842"}],"container-title":["Canadian Journal of Neurological Sciences \/ Journal Canadien des Sciences Neurologiques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0317167117002396","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T21:45:57Z","timestamp":1555364757000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0317167117002396\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,8]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["S0317167117002396"],"URL":"https:\/\/doi.org\/10.1017\/cjn.2017.239","relation":{},"ISSN":["0317-1671","2057-0155"],"issn-type":[{"value":"0317-1671","type":"print"},{"value":"2057-0155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,8]]}}}