{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T14:56:12Z","timestamp":1789916172229,"version":"4.0.1"},"reference-count":39,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T00:00:00Z","timestamp":1526256000000},"content-version":"unspecified","delay-in-days":13,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A majority of patients with Guillain-Barr\u00e9 syndrome (GBS) have tendency of a good recovery. Our aim was to evaluate the outcome of the disease 1 and 3 years after GBS symptom onset. <jats:bold><jats:italic>Methods:<\/jats:italic><\/jats:bold> During 2014, GBS was diagnosed in 82 patients in seven tertiary healthcare centers. Neurological follow-up was conducted in 57 (70%) patients after 1 year, and in 54 (66%) after 3 years. Functional disability was estimated according to the GBS disability scale (GDS), with a score of 0-3 indicating mild disability and a score of 4-6 indicating severe disability during acute phase, whereas a score &gt;1 indicated poor recovery on follow-ups. Visual analog scale was used to assess sensory symptoms and musculoskelatal pain, and Krupp\u2019s Fatigue Severity Scale was used to asses fatigue. <jats:bold><jats:italic>Results:<\/jats:italic><\/jats:bold> Poor functional outcome was found in 39% of GBS patients at year 1 and 30% at year 3. Paresthesias\/dysesthesias were detected in 60% of patients after 1 year and 43% after 3 years. Musculoskeletal pain was present in 40% of patients at year 1 and 33% at year 3. Significant fatigue after 1 year was found in 21% of subjects and after 3 years in 7%. Parameters associated with poor functional outcome after 1 year were age &gt;55 years (<jats:italic>p<\/jats:italic>=0.05), severe disability at admission (<jats:italic>p<\/jats:italic>&lt;0.05), and on discharge (<jats:italic>p<\/jats:italic>&lt;0.01). Poor functional outcome after 3 years was associated with male gender (<jats:italic>p<\/jats:italic>&lt;0.05) and severe disability on discharge (<jats:italic>p<\/jats:italic>=0.06). <jats:bold><jats:italic>Conclusion:<\/jats:italic><\/jats:bold> One and even three years after GBS onset, a substantial number of patients had neurological sequelae, including functional disability, sensory symptoms, pain, and fatigue.<\/jats:p>","DOI":"10.1017\/cjn.2018.12","type":"journal-article","created":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T09:46:33Z","timestamp":1526291193000},"page":"269-274","source":"Crossref","is-referenced-by-count":15,"title":["Three-Year Follow-Up Study in Patients with Guillain-Barr\u00e9 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