{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T22:29:09Z","timestamp":1748816949421},"reference-count":38,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2018,8,6]],"date-time":"2018-08-06T00:00:00Z","timestamp":1533513600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0317167118000689_abs1\" sec-type=\"general\"><jats:title>Objective<\/jats:title><jats:p>Amyotrophic lateral sclerosis (ALS) is a neurodegenerative condition that primarily affects motor neurons. Cognitive changes are reported in 25%-50% of patients, secondary to frontotemporal involvement. The objective of this study was to evaluate the utility of a screening tool, the Addenbrooke\u2019s Cognitive Examination (ACE), in ALS patients.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167118000689_abs2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>In this retrospective cross-sectional study, performance on the ACE was compared between 55 ALS patients and 49 healthy controls. The validation of the ACE in ALS patients was explored using a neuropsychometric battery. Correlations between the ACE and clinical variables such as the ALS Functional Rating Scale-Revised (ALSFRS-R) and forced vital capacity were computed.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167118000689_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>A higher percentage of patients were below cut-off scores, although this remained non-significant between the patient and control groups. The ACE did not reveal significant differences between ALS patients and controls. The scores on the ACE displayed moderate correlations with our neuropsychometric battery for some domains, whereas others showed poor or no associations. Poor ACE Total was associated with lower ALSFRS-R and finger-tapping scores.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167118000689_abs4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>Performance on the ACE was comparable between patients and controls. Associations with motor function pose a challenge to accurate interpretation of ACE performance. It is likely that patients with poor cognition have greater disability, or that poor ACE performance reflects reduced motor ability to perform the task. This raises concern for the utility of the ACE as a screening tool in ALS patients, especially since recent versions of the ACE continue to include motor-based tasks.<\/jats:p><\/jats:sec>","DOI":"10.1017\/cjn.2018.68","type":"journal-article","created":{"date-parts":[[2018,8,6]],"date-time":"2018-08-06T09:17:38Z","timestamp":1533547058000},"page":"527-532","source":"Crossref","is-referenced-by-count":4,"title":["Utility of the Addenbrooke\u2019s Cognitive Examination in Amyotrophic Lateral Sclerosis"],"prefix":"10.1017","volume":"45","author":[{"given":"Sneha","family":"Chenji","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennell","family":"Mah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Camicioli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay","family":"Kalra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2018,8,6]]},"reference":[{"key":"S0317167118000689_ref29","doi-asserted-by":"publisher","DOI":"10.1159\/000366040"},{"key":"S0317167118000689_ref26","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2013.00178"},{"key":"S0317167118000689_ref9","volume-title":"WAIS-R: Wechsler adult intelligence scale-revised","author":"Wechsler","year":"1981"},{"key":"S0317167118000689_ref1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2011-300188"},{"key":"S0317167118000689_ref10","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/17.6.547"},{"key":"S0317167118000689_ref24","doi-asserted-by":"publisher","DOI":"10.3109\/21678421.2014.966311"},{"key":"S0317167118000689_ref21","doi-asserted-by":"publisher","DOI":"10.3109\/17482968.2011.639376"},{"key":"S0317167118000689_ref15","unstructured":"Wechsler D . Wechsler Test of Adult Reading: WTAR. San Antonio, TX: Psychological Corporation; 2001."},{"key":"S0317167118000689_ref16","unstructured":"Delis DC , Kramer JH , Kaplan E . CVLT-II: California Verbal Learning Test: Adult version. Manual. San Antonio, TX: Psychological Corporation; 2000."},{"key":"S0317167118000689_ref27","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610213002329"},{"key":"S0317167118000689_ref23","doi-asserted-by":"publisher","DOI":"10.3109\/21678421.2014.987301"},{"key":"S0317167118000689_ref38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2017.02.061"},{"key":"S0317167118000689_ref14","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4679(197607)32:3<654::AID-JCLP2270320336>3.0.CO;2-Z"},{"key":"S0317167118000689_ref20","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1610"},{"key":"S0317167118000689_ref36","doi-asserted-by":"publisher","DOI":"10.3109\/17482961003727954"},{"key":"S0317167118000689_ref7","doi-asserted-by":"publisher","DOI":"10.1080\/146608200300079536"},{"key":"S0317167118000689_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"S0317167118000689_ref32","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(99)00146-3"},{"key":"S0317167118000689_ref3","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000434309.85312.19"},{"key":"S0317167118000689_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(99)00210-5"},{"key":"S0317167118000689_ref35","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4258"},{"key":"S0317167118000689_ref22","doi-asserted-by":"publisher","DOI":"10.3109\/21678421.2013.809763"},{"key":"S0317167118000689_ref4","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.11.1621"},{"key":"S0317167118000689_ref37","doi-asserted-by":"publisher","DOI":"10.3109\/21678421.2013.805784"},{"key":"S0317167118000689_ref34","doi-asserted-by":"publisher","DOI":"10.1159\/000351671"},{"key":"S0317167118000689_ref18","unstructured":"Spreen O , Benton AL . Neurosensory center comprehensive examination for aphasia. Victoria, BC: Neuropsychology Laboratory, Department of Psychology, University of Victoria; 1977."},{"key":"S0317167118000689_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(67)90015-2"},{"key":"S0317167118000689_ref25","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12471"},{"key":"S0317167118000689_ref30","doi-asserted-by":"publisher","DOI":"10.3109\/21678421.2014.896927"},{"key":"S0317167118000689_ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2011.07.008"},{"key":"S0317167118000689_ref13","doi-asserted-by":"publisher","DOI":"10.1037\/h0054651"},{"key":"S0317167118000689_ref19","volume-title":"IBM SPSS statistics for Windows, Version 21.0","year":"2012"},{"key":"S0317167118000689_ref28","doi-asserted-by":"publisher","DOI":"10.1177\/0891988715598232"},{"key":"S0317167118000689_ref33","doi-asserted-by":"publisher","DOI":"10.3109\/21678421.2013.760149"},{"key":"S0317167118000689_ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53221.x"},{"key":"S0317167118000689_ref6","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnn.0000182831.47073.e9"},{"key":"S0317167118000689_ref12","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1978.00500300038006"},{"key":"S0317167118000689_ref11","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/47.3.P154"}],"container-title":["Canadian Journal of Neurological Sciences \/ Journal Canadien des Sciences Neurologiques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0317167118000689","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,13]],"date-time":"2019-04-13T21:39:14Z","timestamp":1555191554000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0317167118000689\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,6]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["S0317167118000689"],"URL":"https:\/\/doi.org\/10.1017\/cjn.2018.68","relation":{},"ISSN":["0317-1671","2057-0155"],"issn-type":[{"value":"0317-1671","type":"print"},{"value":"2057-0155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,6]]}}}