{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T23:11:54Z","timestamp":1780528314737,"version":"3.54.1"},"reference-count":68,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T00:00:00Z","timestamp":1600732800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>ABSTRACT:<\/jats:title><jats:sec id=\"S031716712000205X_as1\"><jats:title>Background:<\/jats:title><jats:p>Improvements in management of transient ischemic attack (TIA) have decreased stroke and mortality post-TIA. Studies examining trends over time on a provincial level are limited. We analyzed whether efforts to improve management have decreased the rate of stroke and mortality after TIA from 2003 to 2015 across an entire province.<\/jats:p><\/jats:sec><jats:sec id=\"S031716712000205X_as2\"><jats:title>Methods:<\/jats:title><jats:p>Using administrative data from the Canadian Institute for Health Information\u2019s (CIHI) databases from 2003 to 2015, we identified a cohort of patients with a diagnosis of TIA upon discharge from the emergency department (ED). We examined stroke rates at Day 1, 2, 7, 30, 90, 180, and 365 post-TIA and 1-year mortality rates and compared trends over time between 2003 and 2015.<\/jats:p><\/jats:sec><jats:sec id=\"S031716712000205X_as3\"><jats:title>Results:<\/jats:title><jats:p>From 2003 to 2015 in Ontario, there were 61,710 patients with an ED diagnosis of TIA. Linear regressions of stroke after the index TIA showed a significant decline between 2003 and 2015, decreasing by 25% at Day 180 and 32% at 1 year (p &lt; 0.01). The 1-year stroke rate decreased from 6.0% in 2003 to 3.4% in 2015. Early (within 48 h) stroke after TIA continued to represent approximately half of the 1-year event rates. The 1-year mortality rate after ED discharge following a TIA decreased from 1.3% in 2003 to 0.3% in 2015 (p &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec id=\"S031716712000205X_as4\"><jats:title>Interpretation:<\/jats:title><jats:p>At a province-wide level, 1-year rates of stroke and mortality after TIA have declined significantly between 2003 and 2015, suggesting that efforts to improve management may have contributed toward the decline in long-term risk of stroke and mortality. Continued efforts are needed to further reduce the immediate risk of stroke following a TIA.<\/jats:p><\/jats:sec>","DOI":"10.1017\/cjn.2020.205","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T11:01:36Z","timestamp":1600772496000},"page":"335-343","source":"Crossref","is-referenced-by-count":2,"title":["Reduction in Stroke After Transient Ischemic Attack in a Province-Wide Cohort Between 2003 and 2015"],"prefix":"10.1017","volume":"48","author":[{"given":"Ryan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4622-8951","authenticated-orcid":false,"given":"Arunima","family":"Kapoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Lindsay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Goia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7276-9551","authenticated-orcid":false,"given":"Amy Y. 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