{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:36:29Z","timestamp":1789983389395,"version":"4.0.1"},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T00:00:00Z","timestamp":1608508800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>ABSTRACT:<\/jats:title><jats:sec id=\"S0317167120002711_as1\"><jats:title>Background:<\/jats:title><jats:p>Wild-type transthyretin amyloidosis (wtATTR) is an important cause of heart failure (HF); however, the prevalence and clinical significance of neurologic complications remains uncertain.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167120002711_as2\"><jats:title>Methods:<\/jats:title><jats:p>This analysis reports findings from a single-centre experience of routine neuropathy screening at the time of wtATTR diagnosis by nerve conduction studies and neurologist assessment, compared with age-matched controls.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167120002711_as3\"><jats:title>Results:<\/jats:title><jats:p>Forty-one wtATTR patients were included, 39 (95%) males, mean age 78.4 \u00b1 7.7 years, 22 (54%) New York Heart Association (NYHA) class III\u2013IV HF, along with 15 age-matched controls (mean age 77.1 \u00b1 4.2 years, 80% male). Twenty-one (51%) wtATTR patients were diagnosed with polyneuropathy, 15 (37%) with spinal stenosis, 36 (88%) with carpal tunnel syndrome (CTS) and 14 (34%) with ulnar neuropathy. Comparison diagnoses among controls were 1 (7%), 0, 1 (7%) and 3 (20%), respectively. Among patients with NYHA class III\u2013IV HF, 16 (73%) had polyneuropathy compared with 5 (26%) with class I\u2013II (p &lt; 0.01), odds ratio of 7.5 (95% confidence interval 1.9\u201329.9). After neuropathy screening, 19 (46%) patients were offered neurologic therapy and\/or additional diagnostic evaluation. This included CTS release surgery (16, 39%), neuropathic pain medication (3, 7%), nerve block (1, 2%), wrist splinting (2, 5%) and foot care (1, 2%). Spine imaging was performed for 3 (7%) patients, and deltoid muscle and sural nerve biopsy for 1 (2%) patient.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167120002711_as4\"><jats:title>Conclusions:<\/jats:title><jats:p>Screening of wtATTR patients for neurologic complications resulted in a management change for nearly half. CTS, polyneuropathy and ulnar neuropathy were common. This approach warrants consideration as part of routine assessment for newly diagnosed wtATTR patients.<\/jats:p><\/jats:sec>","DOI":"10.1017\/cjn.2020.271","type":"journal-article","created":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T07:31:41Z","timestamp":1608535901000},"page":"607-615","source":"Crossref","is-referenced-by-count":31,"title":["Utility of Neuropathy Screening for Wild-Type Transthyretin Amyloidosis Patients"],"prefix":"10.1017","volume":"48","author":[{"given":"Angela","family":"Russell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer","family":"Chhibber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Korngut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nowell M.","family":"Fine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2020,12,21]]},"reference":[{"key":"S0317167120002711_ref13","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25203"},{"key":"S0317167120002711_ref5","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2014.102"},{"key":"S0317167120002711_ref10","doi-asserted-by":"publisher","DOI":"10.1002\/mus.22208"},{"key":"S0317167120002711_ref16","doi-asserted-by":"publisher","DOI":"10.1177\/1756285612470192"},{"key":"S0317167120002711_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.04.003"},{"key":"S0317167120002711_ref6","first-page":"1","article-title":"Late-onset peripheral neuropathy in patients with wild type transthyretin amyloidosis (wtATTR)","volume":"27","author":"Zivkovic","year":"2019","journal-title":"Amyloid."},{"key":"S0317167120002711_ref11","first-page":"S171","article-title":"Guidelines in electrodiagnostic medicine. 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